28 research outputs found
On being an honorary member of Arny’s army: some musings about fungal fermentations, secondary metabolism, and scientific communities
The Secondary Metabolite Toxin, Sirodesmin PL, and Its Role in Virulence of the Blackleg Fungus
Early change in left atrial function in patients treated with anthracyclines assessed by real-time three-dimensional echocardiography
Enhanced production of gibberellin A4 (GA4) by a mutant of Gibberella fujikuroi in wheat gluten medium
Haemolytic fungi isolated from sago starch in Papua New Guinea
Sago haemolytic disease (SHD) is a rare but often fatal illness linked to consumption of stale sago starch in Papua New Guinea. Although the aetiology of SHD remains unknown, mycotoxins are suspected. This study investigated whether fungi isolated from Papua New Guinean sago starch were haemolytic. Filamentous fungi and yeasts from sago starch were grown on sheep blood agar and some on human blood agar. Clear haemolytic activity was demonstrated by 55% of filamentous fungal isolates, but not by yeasts. A semi-quantitative bioassay was developed involving incubation of human erythrocytes with fungal extracts. Extracts of cultures of Penicillium, Aspergillus and Fusarium all caused rapid haemolysis in the bioassay. Partial fractionation of extracts suggested that both polar and non-polar haemolytic components had haemolytic activity in vitro. Further work is warranted to identify these metabolites and determine if they play a role in SHD