6 research outputs found
A Guide to Safety in Dermatologic Cosmetic Procedures: Avoidance and Management of Common Pitfalls and Perils
- Author
- A Lee
- A Tafazzoli
- AH Scultetus
- AJ Vartanian
- AP Sclafani
- AS Glaich
- B Meier
- BE Crowner
- D Cassuto
- D Dressler
- D Lazzeri
- DM Duffy
- GD Monheit
- GS Munavalli
- HB Gladstone
- HJ Brody
- HJ Park
- J Dudelzak
- J Niamtu 3rd
- J Niamtu 3rd
- JD Peterson
- JF Sobanko
- JL Cohen
- JM Lewin
- K Beer
- KC Yu
- KL Beasley
- KR Beer
- KY Park
- M Alam
- M Alam
- M Moers-Carpi
- MF Brin
- MM Avram
- MR Alexiades-Armenakas
- MV Forlee
- N Morrison
- N Scheinfeld
- NJ Lowe
- NS Shah
- PK Nootheti
- R Glogau
- RG Glogau
- RS Narins
- RS Narins
- S Leu
- S Omoigui
- SB Allen
- SE Cox
- SH Dayan
- SR Youker
- TR Cote
- WL Barrett
- WW Wong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
In-transit metastatic cutaneous melanoma: current management and future directions
- Author
- A Ribas
- A Sanki
- A Testori
- A Testori
- AA Santillan
- AA Tarhini
- AC Buzaid
- AK Raymond
- AMM Eggermont
- BA Byers
- BL Liu
- BS Jiang
- BW Kuvshinoff
- C Hoeller
- C O’Donoghue
- C-CH Stucky
- CE Ariyan
- CE Ariyan
- CF Temple-Oberle
- CK Augustine
- CP Karakousis
- CY Chai
- D Moreno-Ramirez
- DB Johnson
- DG Coit
- DG Coit
- DJ Grunhagen
- DL Morton
- DM Pardoll
- DT Pointer Jr
- E Gabriel
- E McClure
- E Nan Tie
- EM Noorda
- FJ Kohlhapp
- FK Storm
- G Dranoff
- GM Beasley
- GM Beasley
- GT Gibney
- GV Long
- GV Long
- GV Long
- HM Kroon
- HM Kroon
- I Puzanov
- IH Wolf
- J Chesney
- J Schachter
- J Teras
- J Weber
- J Weber
- J Weber
- J Wieberdink
- JA Perone
- JC Hu
- JC Robinson
- JD Wolchok
- JF Thompson
- JF Thompson
- JF Thompson
- JK Tan
- JM Thomas
- JS Zager
- JT Miura
- JT Miura
- JW Eklund
- L Hafstrom
- LA Dossett
- MC Perez
- MG Moller
- MH Cohen
- MH Squires 3rd
- ML Nasi
- NN Senzer
- O Creech Jr
- P Sharma
- P Toomey
- PJ Speicher
- R Olofsson
- RH Andtbacka
- RH Andtbacka
- RH Kubin
- RJ Louie
- RJ Marsh
- RL Read
- RL Read
- RM Conry
- SS Agarwala
- SS Agarwala
- SS Agarwala
- TM Johnson
- TM Pawlik
- TM Pawlik
- TR Hercus
- V Belgrano
- W Liao
- WB Coley
- XD Dong
- Y Shi
- Z Si
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Bilateral anterior Stafne bone defect mimicking radicular cyst: report of a rare case with a review of the literature
- Author
- A Bergenholtz
- A Buchner
- A Courten de
- A Mizuno
- A Phillips
- AE Sekerci
- Ahmet Ercan Sekerci
- AS Abramson
- AS Miller
- AS Miller
- B Slasky
- C Strom
- C Ström
- D Apruzzese
- D Dolanmaz
- E Olech
- EC Stafne
- ED Shields
- EG Mainous
- EL Childers
- EL Layne
- EL Richard
- G Anneroth
- G Barrer
- G Camilleri
- GN Gorab
- GR Seward
- H Shibata
- HP Philipsen
- J Friedman
- J Katz
- J Samson
- J Samson
- J Wolf
- JB Ludlow
- JD Beasley 3rd
- JR Sandy
- K Minowa
- K Minowa
- K Thoma
- K Tominaga
- K Turkoglu
- L Salman
- L Salman
- LG Hansson
- LM Queiroz
- LP Thomas
- LW Solomon
- M Araiche
- M Dorman
- M Etöz
- M Finnegan
- M Malkin
- M Shimizu
- M Wakoh
- MA Copete
- MB Gosney
- MH Smith
- MM Bornstein
- MS Connor
- N Kyung-Soo
- NA Drage
- NC Choukas
- O Alvares
- PH Silva
- R Belmonte-Caro
- RA Plezia
- RE Wood
- RJ Scholl
- RP Langlais
- RW Mann
- RW Mann
- S Barak
- S Prapanpoch
- SC White
- T Stene
- TJ Grellner
- VS Pallodino
- W Forrest
- W Harvey
- WS Amaral
- Y Hayashi
- Y Segev
- Y Sisman
- Y Sisman
- Yildiray Sisman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Exploring Staphylococcus aureus pathways to disease for vaccine development
- Author
- A Dryla
- A Krause
- A Pietrangelo
- A Sahu
- A Xiong
- AE Hall
- AG Cheng
- AI Fattom
- AM Megiovanni
- AM Palazzolo-Ballance
- Andrea DeDent
- B Furie
- B Guss
- B Modun
- B Postma
- BP Thornton
- BR Lutz
- BS Coller
- C Pigeon
- CA Finch
- CH Park
- CK Edwards 3rd
- CS Goodyear
- CW Yang
- D McDevitt
- D McDevitt
- D McDevitt
- D Ricklin
- DD Strong
- DE Isenman
- DG Moore
- DL Stauff
- DL Stauff
- Dominique Missiakas
- DS Abi Abdallah
- E Nemeth
- E Nemeth
- E Panther
- ED Weinberg
- EH Sasso
- EJ Walsh
- EP Skaar
- EP Skaar
- ER Giblett
- ES Duthie
- EW Davie
- FA Ford
- FA Khan
- FC Beasley
- FD Lowy
- FR Toapanta
- G Hasko
- G Nicolas
- G Nicolas
- G Pishchany
- GA Zimmerman
- GJ Silverman
- GJ Silverman
- GL Challis
- H Etz
- H Shinefield
- HC Hemker
- HC Neu
- HF Chambers
- HF Chambers
- HK Kroh
- Hwan Keun Kim
- I Jongerius
- IM Nilsson
- J Bjerketorp
- J Bjerketorp
- J Hartleib
- J Hawiger
- J Mack
- J Sjodahl
- J Vernachio
- JA Cooper
- JD Lambris
- JF Smith
- JH Crosa
- JI Gallin
- JJ Bullen
- JJ Cook
- JJ Pisano
- JJ Weems Jr
- JL Cotton
- JL Van Snick
- JL van Snick
- JP Donahue
- JS Bennett
- JW Eaton
- K Haupt
- K Seki
- KL Atkins
- KP van Gisbergen
- L Loeb
- LM Baddour
- M Brown
- M DeJonge
- M Di Nisio
- M Fluckinger
- M Kopf
- M Kristiansen
- M Liu
- M Pluym
- M Tager
- M Thakker
- M Yanagisawa
- MB Fischer
- MD Knutson
- MD Raedler
- MI Gomez
- MJ Horsburgh
- MJ Horsburgh
- MJ Horsburgh
- MT Sebulsky
- MT Sebulsky
- MT Tiedemann
- N Hasegawa
- N Muryoi
- NA Kuklin
- O Schneewind
- Olaf Schneewind
- P Jonsson
- P Moreillon
- P Panizzi
- P Panizzi
- P Phonimdaeng
- P Phonimdaeng
- PJ Hill
- PL Giesen
- PL Giesen
- PS Hair
- PW Dempsey
- R Friedrich
- R Langley
- R Lindmark
- R Wu
- RD Ekstedt
- RG Macfarlane
- RL Adams
- RL Huff
- RM Klevens
- RM Senior
- S Kaida
- S Rivera
- S Ware
- SE Dale
- SE Dale
- SH Rooijakkers
- SJ Peacock
- SJ Projan
- SK Mazmanian
- SK Mazmanian
- SK Mazmanian
- SR Clarke
- T Nguyen
- T Sawai
- T Uchida
- TH Flo
- TJ Foster
- TJ Foster
- V Thammavongsa
- VJ Torres
- VJ Torres
- VK Ganesh
- W Kolle
- W Nieuwenhuizen
- W Smith
- WT Morgan
- WW Bakker
- Y Nemerson
- YK Stranger-Jones
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
- Author
- Abalos-Galito M
- Abboy C
- Abrahamian F
- Abreu E
- Ackerman If
- Acosta Ia
- Adams L
- Adaoag Aa
- Adiaz-Baui Tt
- Aggarwal Nk
- Aguilar Dominguez Pe
- Aguilar-Orozco Ra
- Aguirre Sosa I
- Ahmed M
- Aleksandrova E
- Alekseeva E
- Alexandrescu Ds
- Ali Mi
- Allen GG Jr
- Allen Dr
- Allison Dc
- Altieri Hh
- Alvey Jc
- Alwine Lk
- Amer L
- Anand S
- Andrasofszky Z
- Anspach Rb
- Antuni Jd
- Antépara Ercoreca I
- Anwar J
- Apaliski Sj
- Arastu Rs
- Aries Sp
- Arimah C
- Arnedillo Muñoz A
- Arora Cm
- Arthur Cp
- Asherova I
- Auerbach D
- Austri Investigators
- Azzam Sj
- Babyesiza A
- Backer V
- Badar FL 3rd
- Badat A
- Baker Jw
- Balakrishnan K
- Balthazar Y
- Banovcin P
- Barasch Jp
- Barbarash Ol
- Barbe Illa F
- Barber Ma
- Bardin Pg
- Bardinas-Rodriguez R
- Barnes Nc
- Barreiro López B
- Barreiro Tj
- Barros Monge Mj
- Barth D
- Bartha A
- Bartuzi Z
- Bassa A
- Bauler A
- Baumbach Rr
- Baur Ce
- Baxter Bs
- Beach Jl
- Beasley Rl
- Beavins Je
- Beliveau Wj
- Benbow Mj
- Benedix A
- Bennett Nl
- Bennett Rl
- Berenfus Vi
- Berg P
- Bergna Ma
- Bergtholdt B
- Bernal H
- Bernan Ap
- Bernstein Di
- Besh L
- Bettig U
- Bielous-Wilk A
- bin Abdul Aziz Fa
- Bindig Hw
- Blaiss Ms
- Blanco Aparicio M
- Blumenthal Kw
- Boada Valmaseda A
- Boas Sr
- Bolivar Grimaldos F
- Bolliger Ct
- Bonavia M
- Borders Jl
- Boscia Ja
- Bosque García M
- Botzen U
- Boulware Wn
- Bowling Bt
- Bożek A
- Brabec Ba
- Braga M
- Bramlet Dg
- Brautigam Df
- Breedt J
- Brehler R
- Breyer Go
- Brown V
- Brownell Jm
- Bruce Tr
- Bruckhaus-Walter M
- Bruning A
- Brzostek J
- Buaron Ks
- Bugrova O
- Bukreeva Eb
- Buresova M
- Burhan H
- Bursova J
- Bustamante Ruiz A
- Butkovic-Tomljanovic R
- Błażowski Ł
- Call Rs
- Calvo Gil Ma
- Campbell Ca
- Canaan Ya
- Cannon Df
- Carpio Jm
- Carretero Anibarro P
- Carroll Pa
- Castillo Hofer Cr
- Cathcart Ws
- Cerveri I
- Cevallos Jp
- Chapman Kr
- Chaudhuri R
- Chauhan Av
- Cheng Sl
- Chermenskiy A
- Chern Jh
- Chetta Aa
- Chevalier D
- Chiu Mh
- Chizhova O
- Choi I
- Chomiciene A
- Chorostowska-Wynimko J
- Christensen J
- Christensen Ta
- Christina Mo
- Chrzanowski Rr
- Chuang Rb
- Chung Cl
- Ciekalska K
- Cieslicki J
- Cirule I
- Cisneros Am
- Civitarese Fa
- Clark Jp
- Clements Bs
- Clifford Dp
- Coggi Ja
- Cohen Kr
- Collier D
- Collins Bg
- Collins H
- Comellas A
- Condit J
- Cordasco EM Jr
- Corder Cn
- Covar Ra
- Coverston Kd
- Crimi N
- Croce Sa
- Cruz H
- Csanadi Ma
- Cuadrado Ja
- Curtis Ct
- Cutrera R
- Daftary Pk
- Dalan D
- Dalawari Sp
- Daly Wc
- Dapper T
- Daud M
- Davies Ej
- Davis Kc
- Davoliene I
- Dawes Kw
- De Gennaro Ms
- De Rosa M
- De Valle Ol
- Decotiis Ba
- Del Campo Matias F
- Deluca Rf
- Demko I
- Desantis Dm
- Dhillon R
- Diaz Amor Pv
- Diaz Jd
- Diaz Jl
- Dice Jp
- Dimitrova R
- Dimova D
- Diogo Jj
- Dixon C
- Djajalaksana S
- Dobkin La
- Dobrusin Rs
- Dopudja Pantic V
- Dore Nd
- Dransfield Mt
- Dudnyk O
- Duka Kd
- Dupont Lj
- Ebbeling Wl
- Echave-Sustaet Jm
- Eckhard Jg
- Edwards Jd
- Eglite R
- Elacion Jm
- Elizalde A
- Elkayam D
- Ellery A
- Ellis Gc
- Ellison Wt
- Elsen Jr
- Emanuel S
- Emeryk A
- Emmett Ah
- Engel Lr
- Engelhard R
- Ensz Dj
- Ericksen Cl
- Ervin Je
- Espinosa de los Monteros Garde Mj
- Esposito S
- Estrella Viladegut Ra
- Evdokimova A
- Fang C
- Farkas M
- Farrah Vb
- Fazio Lizandrelo Cl
- Feldmeyer F
- Field Jd
- Figueroa Dp
- Fishman Hj
- Fissan H
- Fitzgerald Da
- Florea R
- Focauld F
- Focil A
- Folcik K
- Foresi A
- Forstner B
- Fouche Lf
- Franco MA Jr
- Frandsen Br
- Franz Kh
- Fratrik J
- Frick Bs
- Fulat Ma
- Funck J
- Fushtey Im
- Gammeri E
- Gani M
- Ganti K
- Garcia Hernandez Gm
- Garcia Fl
- Garmash N
- Garscadden Ag
- Garza-Salinas S
- Gatti Ea
- Gattolin G
- Gawlik R
- Gałuszka-Bilińska A
- Gellady Am
- George Ar
- Gessner Cm
- Gibbon Gw
- Giejlo M
- Ginko T
- Giorgadze Ml
- Gleason Gp
- Godlevska O
- Goldberg P
- Goldstein Mf
- Gonzalez Ge
- Gosn Am
- Gower Rg
- Grande Ja
- Gregory D
- Grigat Ce
- Grigoryev S
- Grimm-Sachs V
- Griskeviciene V
- Groth G
- Grubb Sd
- Guthrie Rp
- Guttlerova E
- Gömöri K
- Haas Ta
- Haft Ks
- Hajal R
- Hamelmann E
- Hammond Gd
- Hampf J
- Hanf G
- Hansel Nn
- Hansen Vr
- Harat R
- Harris Af
- Hartman An
- Hartman P
- Harvey Rr
- Havasi-Jost G
- Hazan-Steinberg S
- Headley Dm
- Hegedus-Jungvirth M
- Heigerick Gc
- Heinz Gu
- Heller Bn
- Helm K
- Hendrix El
- Henein S
- Herrod Jn
- Hewitt Mj
- Hines Rl
- Hirdt Ap
- Hirschfield Ja
- Hoeltz S
- Hoffman Ks
- Hofman T
- Hofmann S
- Hogan Ad
- Horvathova H
- Hosler Mr
- Hospodarskyy I
- Howland Wc
- Hsu Cc
- Hsu Fj
- Hubbard Wm
- Hudson Jd
- Huffman C
- Hussain M
- Iashyna L
- Idrisova E
- Iemoli E
- Ioachimescu Oc
- Irkhina I
- Ismail Ai
- Ismail Ms
- Ismail Ym
- Ivkovic-Jurekovic I
- Jaffrani Na
- Jahnz-Różyk K
- Jander R
- Jandl M
- Jasch-Hoppe B
- Jedrzejczak M
- Jiang N
- Jirmanova I
- Johnsen Cr
- Jones Sw
- Jordan Rs
- Joshi Ke
- Jung T
- Junggeburth Jj
- Jurgens Jc
- Kaashmiri Mw
- Kachel T
- Kaik G
- Kaladze M
- Kalafer M
- Kalina P
- Kamdar Ba
- Kamiński D
- Kanuga Jg
- Kao Nl
- Karako P Sr
- Kardos P
- Karetzky M
- Katsetos Jc
- Kay Js
- Kelly Aj
- Kelm Warchol A
- Khurkhurova Nv
- Khvelos Si
- Kim C
- Kim Js
- Kim Wj
- Kimmel Ma
- Kimura Sh
- Kingsley Jk
- Kirstein Jl
- Kis S
- Kissyova Ibrishimova G
- Kleerup Ec
- Klein Rm
- Knueppel W
- Koch T
- Koeberl Gh
- Koh Dw
- Koh Yy
- Kohli N
- Kolman P
- Kolorz C
- Kondyurina Eg
- Konieczny Z
- Korduan M
- Korth-Wiemann B
- Kostin Vi
- Kostromina Vp
- Koura Fa
- Kovacs Sp
- Krakhmalova O
- Kral Km
- Krasko Mp
- Kratzer J
- Kreit Ci
- Kreutter Fm
- Krezdorn Hg
- Kroker A
- Kruell M
- Kryuchko T
- Kubicki Tm
- Kucera M
- Kudelya L
- Kuehne P
- Kulynych Ov
- Kwasniewski A
- Kwok S
- Kwon Ss
- Labuda Jm
- Lai Rs
- Laleko Sl
- Lam As
- Lapidus Rj
- Lara Mm
- Larrateguy Ld
- Latorre Aj
- Lechin Ae
- Lee Jj
- Lee Md
- Lee S
- Lee Sh
- Lee Sk
- Lee Wm
- Legnani Dl
- Lenk U
- Lenney W
- Lenskaya L
- Lentnek Al
- Lenz Jj
- Lesh Kw
- Leszczyński W
- Levashov S
- Levchenko O
- Levins Pf
- Levinsky Dm
- Lezana Soya V
- Liefring E
- Liem Jj
- Lillestol Mj
- Lim H
- Lin Ck
- Litvinova T
- Liu Yc
- Livezey Md
- Lloyd-Turney Cw
- Loboshka Becheva M
- Lockey Rf
- Logvinenko N
- Long Ra
- Lores Obradors L
- Lougheed Md
- Lowe Dw
- Luengo Planas Mt
- Luisetti M
- Lynch Mj
- López Viña A
- Macgillivray Bk
- Machkovska M
- Madjarov S
- Mahadevan Kp
- Mahmood Sm
- Major K
- Makam Sk
- Maloney Mj
- Maltbaek N
- Mandazhieva Pepelanova M
- Mapel D
- Marcipar Am
- Margolis Bd
- Margulies J
- Martin Ee
- Martin Ef
- Martinot Jb
- Martynov A
- Mascolo M
- Maspero Jf
- Mataria H
- Mathur Rn
- Matsuno Fuchigami A
- Mattar Pn
- Maynard Km
- Maynard N
- Mccormick B
- Mcelya M
- Mcevoy Ce
- Mckenzie Wc
- Md Kassim Rm
- Medina Iv
- Medwedeff Le
- Mehta Kd
- Melamed Ir
- Meli Jv
- Merke J
- Merrick Bh
- Meyers Pj
- Mezei M
- Michetti G
- Micke L
- Miller Bt
- Mincewicz G
- Minton Sm
- Miranda Fg
- Mitic Milikic M
- Mitlehner W
- Mizernitski Y
- Mohar De
- Mohd Fadzli Fb
- Monsó Molas E
- Montenegro Ch
- Morris Fa
- Morrison Bs
- Moss Mh
- Mueller H
- Munoz F
- Mészáros I
- Nadaskic R
- Naidenova I
- Naini Gr
- Nakamura Ct
- Naseeruddin S
- Nassim C
- Naudts If
- Naudziunas A
- Naudziunas S
- Navarro Dourdil A
- Navazo Lj
- Nayyar S
- Neamtu Ml
- Nell H
- Nemtsov B
- Nestorovic B
- Neumann G
- Nieto García Aj
- Nieuwoudt G
- Niezgoda K
- Ninane V
- Nissim Je
- Noleva K
- Noor F
- Nordstrom M
- Norman D
- Novozhenov Vg
- O'Connor Tm
- Oberoi Ms
- Offenberger J
- Oldenburg W
- Olszewska-Ziąber A
- Onasz-Manitius M
- Onia Af
- Orr Rr
- Osea Ea
- Overlack A
- Paine Wj
- Palatnik M
- Pandya Hc
- Pangtay D
- Panina Ss
- Panuto Ja
- Panzer F
- Park Cs
- Parker Iw
- Pascoe Sj
- Pasiyeshvili Lm
- Pastorello Ea
- Patel M
- Pavlishchuk S
- Pawlukiewicz M
- Peché R
- Perera Ms
- Perez Chada Rd
- Perez A
- Perpina Tordera M
- Pesci A
- Peters PH Jr
- Petrova I
- Picado Valles C
- Pilette C
- Pimentel SM Jr
- Piotrowicz P
- Piotrowski W
- Pisarczyk-Bogacka E
- Piskorz P
- Pistolesi M
- Plutinsky J
- Pluto Tm
- Poga M
- Pollock Mt
- Popova Vv
- Posner Ls
- Povysilova L
- Pratt Se
- Pravda P
- Prazma Cm
- Pribulova E
- Pritchard Jc
- Prokop-Staszecka A
- Prystupa Ln
- Pudi Kk
- Puig Cm
- Puterman As
- Qaqundah Py
- Quilodran Silva Cn
- Radbill Mk
- Rahman St
- Rai Ib
- Raikhel M
- Raissy Hh
- Rajakulasingam K
- Rakvacs M
- Ramirez-Diaz Sp
- Ramstad Ds
- Ranasinghe Es
- Rangel Os
- Raphiou Ih
- Rapo Se
- Raschal Sp
- Rasmussen Nl
- Reddy Dg
- Rehman Sm
- Reinholz N
- Remppis R
- Reshetko Ov
- Reyes Sr
- Rhodes Rb
- Riegel P
- Riffer E
- Rihal Ps
- Riley ED 4th
- Riva E
- Rizvi Q
- Robinson Pd
- Robinson Pj
- Rodriguez Alvarez Mdel M
- Rodriguez Dh
- Rogers Cm
- Rohlf Jl
- Romaniuk Li
- Romano A
- Romeu H
- Roney Cw
- Ronsick So
- Rosen Jb
- Roslan A
- Rowe Ms
- Rudzeviciene O
- Rueckert P
- Ruoff Ge
- Russo Ma
- Ryan Eh
- S-Naval S
- Saff Rh
- Saini N
- Sajkov D
- Samuels Bs
- Samuelson Rj
- Sandagon Mj
- Saniuk Rj
- Sargeant Wo
- Saunders Mk
- Saura Vinuesa A
- Saway W
- Scarupa Md
- Schaetzl Rj
- Schauer U
- Schear Mj
- Schenkenberger I
- Schlegel V
- Scholz G
- Schroers M
- Schwarz Cm
- Schwittay A
- Scichilone N
- Scott Rb
- Sebert M
- Seddon P
- Segall N
- Seibert Af
- Seidmeyer V
- Seidner Mr
- Seifer Fd
- Serje J
- Serra Batlles J
- Setijadi Ar
- Setyanto Db
- Shah Ms
- Shah Sb
- Shapero Pa
- Sharma R
- Shearer Sd
- Sheikh Sq
- Shepherd Ts
- Sher Er
- Sher Ld
- Sherenkov A
- Shirinsky Vs
- Short Bh
- Shpagina L
- Siddique N
- Silas Pe
- Silva D
- Silverfield Jc
- Simon Sj
- Simunov-Karuza G
- Sirenko I
- Sitar S
- Sitkauskiene B
- Skodric Trifunovic V
- Skoner Dp
- Smalera E
- Smallow Sa
- Smart Ba
- Smiltena I
- Smith Ca
- Smith Ke
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- Ziora D
- Zlatos A
- Zubarenko O
- Zykov K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.
METHODS:
In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation.
RESULTS:
Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001).
CONCLUSIONS:
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group
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- Publication date
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