13 research outputs found
Genetic Versus Environmental Influence on Radial Variation in Myracrodruon urundeuva Wood
Floral anatomy of the Lecointea clade (Leguminosae, Papilionoideae, Swartzieae sensu lato)
Cascading predator control interacts with productivity to determine the trophic level of biomass accumulation in a benthic food web
Large-scale phylogenetic analyses reveal multiple gains of actinorhizal nitrogen-fixing symbioses in angiosperms associated with climate change
Do Low-Mercury Terrestrial Resources Subsidize Low-Mercury Growth of Stream Fish? Differences between Species along a Productivity Gradient
Spatial regulation and organization of DNA replication within the nucleus
Duplication of chromosomal DNA is a temporally and spatially regulated process. The timing of DNA replication initiation at various origins is highly coordinated; some origins fire early and others late during S phase. Moreover, inside the nuclei, the bulk of DNA replication is physically organized in replication factories, consisting of DNA polymerases and other replication proteins. In this review article, we discuss how DNA replication is organized and regulated spatially within the nucleus and how this spatial organization is linked to temporal regulation. We focus on DNA replication in budding yeast and fission yeast and, where applicable, compare yeast DNA replication with that in bacteria and metazoans