104 research outputs found
MRCP compared to diagnostic ERCP for diagnosis when biliary obstruction is suspected: a systematic review
BACKGROUND: Magnetic resonance cholangiopancreatography (MRCP) is an alternative to diagnostic endoscopic retrograde cholangiopancreatography (ERCP) for investigating biliary obstruction. The use of MRCP, a non-invasive procedure, may prevent the use of unnecessary invasive procedures. The aim of the study was to compare the findings of MRCP with those of ERCP by the computation of accuracy statistics. METHODS: Thirteen electronic bibliographic databases, covering biomedical, science, health economics and grey literature were searched. A systematic review of studies comparing MRCP to diagnostic ERCP in patients with suspected biliary obstruction was conducted. Sensitivity, specificity, likelihood ratios, acceptability and adverse events were reported. RESULTS: 25 studies were identified reporting several conditions including choledocholithiasis (18 studies), malignancy (four studies), obstruction (three studies), stricture (two studies) and dilatation (five studies). Three of the 18 studies reporting choledocholithiasis were excluded from the analysis due to lack of data, or differences in study design. The sensitivity for the 15 studies of choledocholithiasis ranged from 0.50 to 1.00 while specificity ranged from 0.83 to 1.00. The positive likelihood ratio ranged: from 5.44–47.72 and the negative likelihood ratio for the 15 studies ranged from 0.00–0.51. Significant heterogeneity was found across the 15 studies so the sensitivities and specificities were summarised by a Receiver Operating Characteristic (ROC) curve. For malignancy, sensitivity ranged from 0.81 to 0.94 and specificity from 0.92 to 1.00. Positive likelihood ratios ranged from 10.12 to 43 and negative likelihood ratios ranged from 0.15 to 0.21, although these estimates were less reliable. CONCLUSION: MRCP is a comparable diagnostic investigation in comparison to ERCP for diagnosing biliary obstruction
Interactions Between a Belowground Herbivore and Primary and Secondary Root Metabolites in Wild Cabbage
Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions
Road traffic noise and children's inattention
BACKGROUND: An increasing number of children are exposed to road
traffic noise levels that may lead to adverse effects on health
and daily functioning. Childhood is a period of intense growth
and brain maturation, and children may therefore be especially
vulnerable to road traffic noise. The objective of the present
study was to examine whether road traffic noise was associated
with reported inattention symptoms in children, and whether this
association was mediated by sleep duration. METHODS: This study
was based on the Norwegian Mother and Child Cohort Study
conducted by the Norwegian Institute of Public Health. Parental
reports of children's inattention at age 8 were linked to
modelled levels of residential road traffic noise. We
investigated the association between inattention and noise
exposure during pregnancy (n = 1934), noise exposure averaged
over 5 years (age 3 to 8 years; n = 1384) and noise exposure at
age 8 years (n = 1384), using fractional logit response models.
The participants were children from Oslo, Norway. RESULTS: An
association with inattention at age 8 years was found for road
traffic noise exposure at age 8 years (coef = .0083, CI =
[.0012, .0154]; 1.2% point increase in inattention score per 10
dB increase in noise level), road traffic noise exposure average
for the last 5 years (coef = .0090, CI = [.0016, .0164]; 1.3%
point increase/10 dB), and for pregnancy road traffic noise
exposure for boys (coef = .0091, CI = [.0010, .0171]), but not
girls (coef = -.0021, CI = [-.0094, .0053]). Criteria for doing
mediation analyses were not fulfilled. CONCLUSION: Results
indicate that road traffic noise has a negative impact on
children's inattention. We found no mediation by sleep duration
An example of enhanced tephra deposition driven by topographically induced atmospheric turbulence
Do sugar-sweetened beverages cause adverse health outcomes in children? A systematic review protocol
The effect of four different freezing conditions and time in frozen storage on the concentration of commonly measured growth factors and enzymes in equine platelet-rich plasma over six months
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