15 research outputs found
Protective effect of swertia chirata against indomethacin and other ulcerogenic agent-induced gastric ulcers
The effect of Swertia chirata has been studied on experimentally induced gastric ulcers in
rats. The ethanolic extract of chirata significantly reduced the intensity of gastric mucosal damage
induced by indomethacin and necrotizing agents. It produced a significant decrease in gastric secretion
•in pylorus-ligated rats. The extract inhibited acetylcholine-induced contraction of guinea pig ileum,
suggesting its anti-cholinergic activity. Pretreatment of rats with the extract significantly prevented
ethanol-induced gastric wall mucus depletion and restored the non-protein sulfhydryl (NP-SH) content in
the glandular stomachs. These findings support the use of chirata for the treatment of gastric ulcers in
traditional medicine.Corresponding Author:
Dr. Syed Rafatullah, Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University,
P.O. Box 2457, Riyadh-11451, Saudi Arabia.
Email: [email protected]