The genes for the inter-α-inhibitor family share a homologous organization in human and mouse

Inter-α-inhibitor ( IαI ) and related molecules in human are comprised of three evolutionarily related, heavy (H) chains and one light (L) chain, also termed bikunin. The latter originates from a precursor molecule that is cleaved to yield the bikunin and another protein designated α-1-microglobulin (A1m). The four H and L chains are encoded by four distinct genes designated H1, H2, H3 , and L . The L and H2 genes are localized onto human chromosomes (chr) 9 and 10, respectively, whereas the H1 and H3 genes are tandemly arranged on chr 3.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46989/1/335_2004_Article_BF00355432.pd

The H4P heavy chain of inter-α-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human

The family of plasma proteins collectively referred to as Inter-α-Inhibitor (IαI) family is comprised of a set of multi-polypeptide molecules and a single-chain molecule designated IαIH4P. Although the 4 heavy chain precursors H1P to H4P that lead to these molecules are evolutionarily related, only H4P harbours a Pro-rich region (PRR) in its C-terminal third. A comparison of hepatic H4P cDNAs in human and rat has now unraveled an extensive variability of this PRR. Within the rat PRR, 6 repeats of a Gly-X-Pro motif participate in a collagen-like pattern that is absent in human. Within the human PRR, a domain that is absent in rat can be transcribed or deleted by alternative splicing which results in two variant forms of human H4P. In rat liver, the single mRNA is up-regulated by an acute, systemic inflammation whereas neither mRNA is up-regulated in human liver. Finally the shortest human mRNA is also transcribed in peripheral blood mononuclear cells where it is down-regulated by bacterial lipopolysaccharides. Therefore, in contrast to what is seen for theITIH1to-3genes, the rat and humanITIH4gene transcriptions and products thereof present marked differences, which suggests species-specific functions for IαIH4P

Information transmission in energy futures markets

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Human Inter-alpha-Trypsin-Inhibitor: Characterization and partial nucleotide sequencing of a light chain-encoding cDNA

International audienceA synthetic Inter-alpha-Trypsin-Inhibitor (ITI) -specific oligonucleotide probe was used to isolate a clone from a human liver cDNA library. The amino-acid sequence deduced from partial nucleotide sequencing of the corresponding cDNA insert perfectly matched a known ITI sequence, apart from an as yet unreported C-terminal dipeptide. Hybridization on Northern blots evidenced that this cDNA insert originated from an ITI light chain-encoding mRNA whose size was estimated to be 1 300 bases