45 research outputs found
Association of biomarkers with osteoarthritis progression based on MRI: results from the Vancouver knee osteoarthritis progression (KOAP) study
Crystallization studies of the β (Mg2Pb) phase and its phase boundaries in the Pb-Mg-Bi system
304 QUANTIFYING DECLINE IN QUALITY OF LIFE DUE TO DISEASE DURATION IN PERSONS WITH PRE-EXISTING KNEE OR HIP OSTEOARTHRITIS
323 DO PHYSICAL EXAMINATIONS PREDICT OA PROGRESSION BASED ON MRI? RESULTS FROM THE VANCOUVER KNEE OSTEOARTHRITIS PROGRESSION STUDY
Associations between knee pain severity and progression versus MRI features: The vancouver longitudinal study of early knee OA
Predicting OA progression: results from the Vancouver knee osteoarthritis progression study
302 COMPARING MAGNETIC RESONANCE IMAGING-BASED DEFINITIONS OF KNEE OSTEOARTHRITIS TO X-RAY-BASED KELLGREN-LAWRENCE GRADE FOR PREDICTING DISEASE SEVERITY
289 THE EFFECT OF PHYSICIAN ASSESSED QUADRICEPS MUSCLE STRENGTH ON SUBSEQUENT PROGRESSION OF KNEE OSTEOARTHRITIS (OA)
The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study
SummaryPurposeTo assess the association between subchondral sclerosis detected at baseline with MRI and cartilage loss over time in the same region of the knee in a cohort of subjects with knee pain.Methods163 subjects with knee pain participated in a longitudinal study to assess knee osteoarthritis progression (KOAP). Subjects received baseline knee radiographs as well as baseline and 3-year follow-up MRI examinations. Baseline subchondral sclerosis and bone marrow lesions (BMLs) were scored semiquantitatively on MRI in each region from 0 to 3. Cartilage morphology at baseline and follow-up was scored semiquantitatively from 0 to 4. The association between baseline subchondral sclerosis and cartilage loss in the same region of the knee was evaluated using logistic regression, adjusting the results for age, gender, body mass index, and the presence of concomitant BMLs.ResultsThe prevalence of subchondral sclerosis detected by MRI in the regions of the knee varied between 1.6% (trochlea) and 17% (medial tibia). The occurrence of cartilage loss over time in regions varied between 6% (lateral tibia) and 13.1% (medial femur). The prevalence of radiographically-detected subchondral sclerosis in compartments varied from 2.9% (patellofemoral) to 14.2% (medial tibiofemoral). In logistic regression models, there were no significant associations between baseline subchondral sclerosis detected by MRI and cartilage loss in the same region of the knee.ConclusionBaseline subchondral sclerosis as detected by MRI did not increase the risk of cartilage loss over time