27 research outputs found
An All-Feline Retroviral Packaging System for Transduction of Human Cells
Doty et al. in this technical report generate and characterize a helper-free, packaging system composed entirely of feline leukemia virus subgroup C (FeLV-C) components. Using this new packaging system, the authors demonstrate that they can produce higher titer vectors than existing gammaretroviral packaging systems
The effect of human fit- 3 ligand on committed progenitor cell production from normal, aplastic anaemia and Diamond-Blackfan anaemia bone marrow
Diamond-Blackfan anaemia: three patterns of in vitro response to haemopoietic growth factors
Repetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate
Safety studies designed to evaluate genotoxicity of retroviral gene therapy agents may require long-term follow-up, hampering their progression to the clinic. Here, Xie et al. tested the hypothesis that hematopoietic stress in a nonhuman primate model of ex vivo hematopoietic stem cell gene therapy accelerated proliferation and the detection of clonal dominance