27 research outputs found
An All-Feline Retroviral Packaging System for Transduction of Human Cells
No full textDoty et al. in this technical report generate and characterize a helper-free, packaging system composed entirely of feline leukemia virus subgroup C (FeLV-C) components. Using this new packaging system, the authors demonstrate that they can produce higher titer vectors than existing gammaretroviral packaging systems
The effect of human fit- 3 ligand on committed progenitor cell production from normal, aplastic anaemia and Diamond-Blackfan anaemia bone marrow
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Diamond-Blackfan anaemia: three patterns of in vitro response to haemopoietic growth factors
No full textRepetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate
No full textSafety studies designed to evaluate genotoxicity of retroviral gene therapy agents may require long-term follow-up, hampering their progression to the clinic. Here, Xie et al. tested the hypothesis that hematopoietic stress in a nonhuman primate model of ex vivo hematopoietic stem cell gene therapy accelerated proliferation and the detection of clonal dominance
Enrichment of haemopoietic progenitor cells from the marrow of patients with myelodysplasia
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On the in situ formation of tic and ti2c reinforcements in combustion-assisted synthesis of titanium matrix composites
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