Bound Chains of Tilted Dipoles in Layered Systems

Ultracold polar molecules in multilayered systems have been experimentally realized very recently. While experiments study these systems almost exclusively through their chemical reactivity, the outlook for creating and manipulating exotic few- and many-body physics in dipolar systems is fascinating. Here we concentrate on few-body states in a multilayered setup. We exploit the geometry of the interlayer potential to calculate the two- and three-body chains with one molecule in each layer. The focus is on dipoles that are aligned at some angle with respect to the layer planes by means of an external eletric field. The binding energy and the spatial structure of the bound states are studied in several different ways using analytical approaches. The results are compared to stochastic variational calculations and very good agreement is found. We conclude that approximations based on harmonic oscillator potentials are accurate even for tilted dipoles when the geometry of the potential landscape is taken into account.Comment: 10 pages, 6 figures. Submitted to Few-body Systems special issue on Critical Stability, revised versio

Production of a dual-species Bose-Einstein condensate of Rb and Cs atoms

We report the simultaneous production of Bose-Einstein condensates (BECs) of $^{87}$Rb and $^{133}$Cs atoms in separate optical traps. The two samples are mixed during laser cooling and loading but are separated by $400 \mu$m for the final stage of evaporative cooling. This is done to avoid considerable interspecies three-body recombination, which causes heating and evaporative loss. We characterize the BEC production process, discuss limitations, and outline the use of the dual-species BEC in future experiments to produce rovibronic ground state molecules, including a scheme facilitated by the superfluid-to-Mott-insulator (SF-MI) phase transition

Central radiology assessment of the randomized phase III open-label OVHIPEC-1 trial in ovarian cancer

INTRODUCTION: Hyperthermic intraperitoneal chemotherapy (HIPEC) improved investigator-assessed recurrence-free survival and overall survival in patients with stage III ovarian cancer in the phase III OVHIPEC-1 trial. We analyzed whether an open-label design affected the results of the trial by central blinded assessment of recurrence-free survival, and tested whether HIPEC specifically targets the peritoneal surface by analyzing the site of disease recurrence. METHODS: OVHIPEC-1 was an open-label, multicenter, phase III trial that randomized 245 patients after three cycles of neoadjuvant chemotherapy to interval cytoreduction with or without HIPEC using cisplatin (100 mg/m2). Patients received three additional cycles of chemotherapy after surgery. Computed tomography (CT) scans and serum cancer antigen 125 (CA125) measurements were performed during chemotherapy, and during follow-up. Two expert radiologists reviewed all available CT scans. They were blinded for treatment allocation and clinical outcome. Central revision included Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 measurements and peritoneal cancer index scorings at baseline, during treatment, and during follow-up. Time to centrally-revised recurrence was compared between study arms using Cox proportional hazard models. Subdistribution models compared time to peritoneal recurrence between arms, accounting for competing risks. RESULTS: CT scans for central revision were available for 231 patients (94%) during neoadjuvant treatment and 212 patients (87%) during follow-up. Centrally-assessed median recurrence-free survival was 9.9 months in the surgery group and 13.2 months in the surgery+HIPEC group (HR for disease recurrence or death 0.72, 95% CI 0.55 to 0.94; p=0.015). The improved recurrence-free survival and overall survival associated with HIPEC were irrespective of response to neoadjuvant chemotherapy and baseline peritoneal cancer index. Cumulative incidence of peritoneal recurrence was lower after surgery+HIPEC, but there was no difference in extraperitoneal recurrences. CONCLUSION: Centrally-assessed recurrence-free survival analysis confirms the benefit of adding HIPEC to interval cytoreductive surgery in patients with stage III ovarian cancer, with fewer peritoneal recurrences. These results rule out radiological bias caused by the open-label nature of the study

Globalism's Siren Song: The United Nations and International Law in Christian Right Thought and Prophecy

The role of the American Christian Right (CR) as an international social movement has perhaps received less attention than it is due. In this article, I explore the underlying global vision of the CR, and the ways in which this vision shapes the CR's international political activism. I focus on the CR's construction of the United Nations, examining various CR genres including movement publications, fiction, and prophecy writing. I also attempt to analyse the CR's ideological stance in light of the literature on `religion and globalisation'