Composition consisting of a dendrimer and an active substance

The invention relates to a composition consisting of a dendrimer provided with blocking agents and an active substance occluded in the dendrimer. According to the invention a blocking agent is a compound which is sterically of sufficient size, which readily enters into a chemical bond with the terminal groups of a dendrimer and which can also be split off from the dendrimer or be modified without thereby affecting the chemical structure of the dendrimer and the active substance. The blocking agent can be provided with protective groups. Such conjugates have the advantage that the time at which the releasing of the active substance starts, can be controlled. The invention also relates to a process for the preparation of such a composition and to a process for the controlled release of the active substance

Asymmetric 1,4-Additions to γ-Menthyloxybutenolides. (part II) Enantioselective Synthesis of Lignan Type Compounds.

Addition of dithianes, derived from alkyl- and aryl-aldehydes, to (5R)-menthyloxy-2[5H]-furanone followed by quenching with substituted benzylhalides or a benzaldehyde gives enantiomerically pure lignan type compounds in good yields

Dendrimer and an active substance occluded in the dendrimer : a process for the preparation thereof and a process for releasing the active substance

The invention relates to a dendrimer composition in which an effective number of the terminal functionalities are provided with blocking agents, and at least one active substance species is occluded in the dendrimer. A blocking agent is a sufficiently sterically sized compound which readily enters into a chemical bond with a terminal group of a dendrimer but which can also be split off from the dendrimer or can be modified without affecting the chemical structure of the dendrimer and the occluded active substance. The blocking agent can also be provided with a protecting group. The time and duration over which an active substance is released can be controlled. The invention also relates to a process for the preparation of such a composition and to a process for the controlled release of the active substance