72 research outputs found
Ten simple rules for reporting voxel-based morphometry studies
Voxel-based morphometry [Ashburner, J. and Friston, K.J., 2000. Voxel-based morphometry—the methods. NeuroImage 11(6 Pt 1), 805–821] is a commonly used tool for studying patterns of brain change in development or disease and neuroanatomical correlates of subject characteristics. In performing a VBM study, many methodological options are available; if the study is to be easily interpretable and repeatable, the processing steps and decisions must be clearly described. Similarly, unusual methods and parameter choices should be justified in order to aid readers in judging the importance of such options or in comparing the work with other studies. This editorial suggests core principles that should be followed and information that should be included when reporting a VBM study in order to make it transparent, replicable and useful
Metabolic dysfunction following weight cycling in male mice
Background: Combatting over-weight or obesity can lead to large fluctuations in an individual‟s body weight, often referred to as weight cycling or “yo-yo” dieting. Current evidence regarding the potentially damaging effects of these changes is conflicting.
Methods: Here, we assess the metabolic effects of weight cycling in a murine model, comprising three dietary switches to normal or high fat diets at 6 week intervals; male C57BL/6 mice were fed either a control (C) or high fat (F) diet for 6 weeks (n=140/group). C and F groups were then either maintained on their initial diet (CC and FF respectively) or
switched to a high fat (CF) or control (FC) diet (n=35/group). For the final 6 week interval, CC and CF groups were returned to the control diet (CCC and CFC groups) while FC and FF groups were placed on a high fat diet (FCF and FFF) (n=28/group).
Results: For the majority of metabolic outcomes changes aligned with dietary switches; however assessment of neuropeptides and receptors involved in appetite regulation and reward signalling pathways reveal variable patterns of expression. Furthermore, we demonstrate that multiple cycling events leads to a significant increase in internal fat
deposition, even when compared to animals maintained on a high fat diet (Internal Fat: FCF: 7.4 ± 0.2g vs. FFF: 5.6 ± 0.2g; p<0.01).
Conclusions: Increased internal adipose tissue is strongly linked to the development of metabolic syndrome associated conditions such as type 2 diabetes, cardiovascular disease
and hypertension. While further work will be required to elucidate the mechanisms underlying the neuronal control of energy homeostasis, these studies provide a causative
link between weight cycling and adverse health
Isospin-Violating Meson-Nucleon Vertices as an Alternate Mechanism of Charge-Symmetry Breaking
We compute isospin-violating meson-nucleon coupling constants and their
consequent charge-symmetry-breaking nucleon-nucleon potentials. The couplings
result from evaluating matrix elements of quark currents between nucleon states
in a nonrelativistic constituent quark model; the isospin violations arise from
the difference in the up and down constituent quark masses. We find, in
particular, that isospin violation in the omega-meson--nucleon vertex dominates
the class IV CSB potential obtained from these considerations. We evaluate the
resulting spin-singlet--triplet mixing angles, the quantities germane to the
difference of neutron and proton analyzing powers measured in elastic
scattering, and find them commensurate to those computed
originally using the on-shell value of the - mixing amplitude.
The use of the on-shell - mixing amplitude at has been
called into question; rather, the amplitude is zero in a wide class of models.
Our model possesses no contribution from - mixing at , and
we find that omega-meson exchange suffices to explain the measured
analyzing power difference~at~183 MeV.Comment: 20 pages, revtex, 3 uuencoded PostScript figure
SO(5) theory of insulating vortex cores in high- materials
We study the fermionic states of the antiferromagnetically ordered vortex
cores predicted to exist in the superconducting phase of the newly proposed
SO(5) model of strongly correlated electrons. Our model calculation gives a
natural explanation of the recent STM measurements on BSCCO, which in
surprising contrast to YBCO revealed completely insulating vortex cores.Comment: 4 pages, 1 figur
Cannabidiol (CBD) is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer
Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst other associated with chemo-resistance and active transfer of pro-oncogenic factors. Recent studies show that EMV-inhibiting agents can sensitise cancer cells to chemotherapeutic agents and reduce cancer growth in vivo. Cannabidiol (CBD), a phytocannabinoid derived from Cannabis sativa, has anti-inflammatory and anti-oxidant properties, and displays anti-proliferative activity. Here we report a novel role for CBD as a potent inhibitor of EMV release from three cancer cell lines: prostate cancer (PC3), hepatocellular carcinoma (HEPG2) and breast adenocarcinoma (MDA-MB-231). CBD significantly reduced exosome release in all three cancer cell lines, and also significantly, albeit more variably, inhibited microvesicle release. The EMV modulating effects of CBD were found to be dose dependent (1 and 5 μM) and cancer cell type specific. Moreover, we provide evidence that this may be associated with changes in mitochondrial function, including modulation of STAT3 and prohibitin expression, and that CBD can be used to sensitise cancer cells to chemotherapy. We suggest that the known anti-cancer effects of CBD may partly be due to the regulatory effects on EMV biogenesis, and thus CBD poses as a novel and safe modulator of EMV-mediated pathological events
Pion Content of the Nucleon as seen in the NA51 Drell-Yan experiment
In a recent CERN Drell-Yan experiment the NA51 group found a strong asymmetry
of and densities in the proton at . We interpret
this result as a decisive confirmation of the pion-induced sea in the nucleon.Comment: 10 pages + 3 figures, Preprint KFA-IKP(TH)-1994-14 .tex file. After
\enddocument a uu-encodeded Postscript file comprising the figures is
appende
Model Analysis of Time Reversal Symmetry Test in the Caltech Fe-57 Gamma-Transition Experiment
The CALTECH gamma-transition experiment testing time reversal symmetry via
the E2/M1 mulipole mixing ratio of the 122 keV gamma-line in Fe-57 has already
been performed in 1977. Extending an earlier analysis in terms of an effective
one-body potential, this experiment is now analyzed in terms of effective one
boson exchange T-odd P-even nucleon nucleon potentials. Within the model space
considered for the Fe-57 nucleus no contribution from isovector rho-type
exchange is possible. The bound on the coupling strength phi_A from effective
short range axial-vector type exchange induced by the experimental bound on
sin(eta) leads to phi_A < 10^{-2}.Comment: 5 pages, RevTex 3.
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