62 research outputs found
Regulation of cyclooxygenase isoforms in the renal thick ascending limb: effects of extracellular calcium
On the contribution of prostaglandin-like substances to the action of bradykinin on intestinal motility and blood flow in canine jejunal loop in situ
Quantification of Intermediate Steps in the Renin-Anglotensin-Vasoconstrictor Feedback Loop in the Dog
EFFECT OF CAPTOPRIL ON BLOOD PRESSURE AND BRADYKININ VASODEPRESSOR RESPONSES AFTER NEPHRECTOMY AND SUPPRESSION OF PROSTAGLANDIN SYNTHESIS IN ANAESTHETIZED RATS
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Cardiovascular and Renal Actions of Cytochrome P-450 Metabolites of Arachidonic Acid
Cytochrome P-450 is the terminal oxidase of the electron transport chain in the endoplasmic reticulum. Arachidonic acid (AA) can be oxidatively metabolized by cytochrome P-450 hemoproteins to an array of compounds identified as constituents of tissues and biological fluids. Their synthesis can be manipulated by pharmacologic probes and are altered in pathophysiologic conditions. These novel eicosanoids stimulate release of peptide and steroid hormones, inhibit platelet and leukocyte aggregation, influence Na+-K+-ATPase and alter vasomotor tone. They also participate in fluid and electrolyte homeostasis, stimulus-secretion coupling, and regulation of tissue blood flow. Since these novel AA metabolites may participate in receptor-mediated signal transduction, and have been implicated in the generation of second messengers and changes in intracellular calcium, these studies have important implications for understanding basic biological mechanisms
Effects of Dopamine on Kidney Function and on the Adenyl Cyclase Phosphodiesterase System in Man
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