4,627 research outputs found
Continuous quantum measurement of a Bose-Einstein condensate: a stochastic Gross-Pitaevskii equation
We analyze the dynamics of a Bose-Einstein condensate undergoing a continuous
dispersive imaging by using a Lindblad operator formalism. Continuous strong
measurements drive the condensate out of the coherent state description assumed
within the Gross-Pitaevskii mean-field approach. Continuous weak measurements
allow instead to replace, for timescales short enough, the exact problem with
its mean-field approximation through a stochastic analogue of the
Gross-Pitaevskii equation. The latter is used to show the unwinding of a dark
soliton undergoing a continuous imaging.Comment: 13 pages, 10 figure
The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency
OBJECTIVE. Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found. Steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) is a key regulator of human sex development and an increasing number of SF-1 (NR5A1) mutations are reported in 46,XY disorders of sex development (DSD). We hypothesized that NR5A1 mutations could be identified in boys with hypospadias.
DESIGN AND METHODS. Mutational analysis of NR5A1 in 60 individuals with varying degrees of hypospadias from the German DSD network.
RESULTS. Heterozygous NR5A1 mutations were found in three out of 60 cases. These three individuals represented the most severe end of the spectrum studied as they presented with penoscrotal hypospadias, variable androgenization of the phallus and undescended testes (three out of 20 cases (15%) with this phenotype). Testosterone was low in all three patients and inhibin B/anti-Müllerian hormone (AMH) were low in two patients. Two patients had a clear male gender assignment. Gender re-assignment to male occurred in the third case. Two patients harbored heterozygous nonsense mutations (p.Q107X/WT, p.E11X/WT). One patient had a heterozygous splice site mutation in intron 2 (c.103-3A/WT) predicted to disrupt the main DNA-binding motif. Functional studies of the nonsense mutants showed impaired transcriptional activation of an SF-1-responsive promoter (Cyp11a). To date, adrenal insufficiency has not occurred in any of the patients.
CONCLUSIONS. SF-1 (NR5A1) mutations should be considered in 46,XY individuals with severe (penoscrotal) hypospadias, especially if undescended testes, low testosterone, or low inhibin B/AMH levels are present. SF-1 mutations in milder forms of idiopathic hypospadias are unlikely to be common
High performance Beowulf computer for lattice QCD
We describe the construction of a high performance parallel computer composed
of PC components, as well as the performance test in lattice QCD.Comment: Lattice 2001 (Algorithms and Machines) 3 page
Stable adaptive fuzzy control with TSK fuzzy friction estimation for linear drive systems
This paper considers the control of a linear drive system with friction and disturbance compensation. A stable adaptive controller integrated with fuzzy model-based friction estimation and switching-based disturbance compensation is proposed via Lyapunov stability theory. A TSK fuzzy model with local linear friction models is suggested for real-time estimation of its consequent local parameters. The parameters update law is derived based on linear parameterization. In order to compensate for the effects resulting from estimation error and disturbance, a robust switching law is incorporated in the overall stable adaptive control system. Extensive computer simulation results show that the proposed stable adaptive fuzzy control system has very good performances, and is potential for precision positioning and trajectory tracking control of linear drive systems
Factors affecting In vitro methane production from cecum contents of White Roman geese
The goal of this research was to gain understanding of in vitro methane (CH4) production from the cecal contents of White Roman geese under various incubation conditions. Five experiments were conducted to ascertain the effects of i) incubation time, ii) pH, iii) the addition of formic acid to the culture media, iv) temperature, and v) the addition of salt to the nutritive liquid. Methane production increased significantly with the supplementation of formic acid in the culture fluid (Experiment III). Additionally, CH4 production Experiment V was higher than that without saline. In contrast, low CH4 production occurred under acidic conditions (pH ≦5.4) and at temperatures higher or lower than typical bird body temperature (43 °C) without formic acid and saline solution in the culture media. Since bird body temperature cannot be controlled easily, approaches such as maintaining cecum fluid at low pH and preventing the formation of formic acid by adjusting the recipes of feeds could be considered for controlling in vivo CH4 production from the intestinal tract digesta of geese
RHESSI Results -- Time For a Rethink?
Hard X-rays and gamma-rays are the most direct signatures of energetic
electrons and ions in the sun's atmosphere which is optically thin at these
energies and their radiation involves no coherent processes. Being collisional
they are complementary to gyro-radiation in probing atmospheric density as
opposed to magnetic field and the electrons are primarily 10--100 keV in
energy, complementing the (>100 keV) electrons likely responsible for microwave
bursts.
The pioneering results of the Ramaty High Energy Solar Spectroscopic Imager
(RHESSI) are raising the first new major questions concerning solar energetic
particles in many years. Some highlights of these results are discussed --
primarily around RHESSI topics on which the authors have had direct research
involvement -- particularly when they are raising the need for re-thinking of
entrenched ideas. Results and issues are broadly divided into discoveries in
the spatial, temporal and spectral domains, with the main emphasis on flare
hard X-rays/fast electrons but touching also on gamma-rays/ions, non-flare
emissions, and the relationship to radio bursts.Comment: Proceedings CESRA Workshop 2004: "The High Energy Solar Corona:
Waves, Eruptions, Particles", Lecture Notes in Physics, 2006 (accepted
Surface and capillary transitions in an associating binary mixture model
We investigate the phase diagram of a two-component associating fluid mixture
in the presence of selectively adsorbing substrates. The mixture is
characterized by a bulk phase diagram which displays peculiar features such as
closed loops of immiscibility. The presence of the substrates may interfere the
physical mechanism involved in the appearance of these phase diagrams, leading
to an enhanced tendency to phase separate below the lower critical solution
point. Three different cases are considered: a planar solid surface in contact
with a bulk fluid, while the other two represent two models of porous systems,
namely a slit and an array on infinitely long parallel cylinders. We confirm
that surface transitions, as well as capillary transitions for a large
area/volume ratio, are stabilized in the one-phase region. Applicability of our
results to experiments reported in the literature is discussed.Comment: 12 two-column pages, 12 figures, accepted for publication in Physical
Review E; corrected versio
Majority versus minority dynamics: Phase transition in an interacting two-state spin system
We introduce a simple model of opinion dynamics in which binary-state agents
evolve due to the influence of agents in a local neighborhood. In a single
update step, a fixed-size group is defined and all agents in the group adopt
the state of the local majority with probability p or that of the local
minority with probability 1-p. For group size G=3, there is a phase transition
at p_c=2/3 in all spatial dimensions. For p>p_c, the global majority quickly
predominates, while for p<p_c, the system is driven to a mixed state in which
the densities of agents in each state are equal. For p=p_c, the average
magnetization (the difference in the density of agents in the two states) is
conserved and the system obeys classical voter model dynamics. In one dimension
and within a Kirkwood decoupling scheme, the final magnetization in a
finite-length system has a non-trivial dependence on the initial magnetization
for all p.ne.p_c, in agreement with numerical results. At p_c, the exact 2-spin
correlation functions decay algebraically toward the value 1 and the system
coarsens as in the classical voter model.Comment: 11 pages, 3 figures, revtex4 2-column format; minor revisions for
publication in PR
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