Space Telescope and Optical Reverberation Mapping Project. VII. Understanding the Ultraviolet Anomaly in NGC 5548 with X-Ray Spectroscopy

During the Space Telescope and Optical Reverberation Mapping Project observations of NGC 5548, the continuum and emission-line variability became decorrelated during the second half of the six-month-long observing campaign. Here we present Swift and Chandra X-ray spectra of NGC 5548 obtained as part of the campaign. The Swift spectra show that excess flux (relative to a power-law continuum) in the soft X-ray band appears before the start of the anomalous emission-line behavior, peaks during the period of the anomaly, and then declines. This is a model-independent result suggesting that the soft excess is related to the anomaly. We divide the Swift data into on- and off-anomaly spectra to characterize the soft excess via spectral fitting. The cause of the spectral differences is likely due to a change in the intrinsic spectrum rather than to variable obscuration or partial covering. The Chandra spectra have lower signal-to-noise ratios, but are consistent with the Swift data. Our preferred model of the soft excess is emission from an optically thick, warm Comptonizing corona, the effective optical depth of which increases during the anomaly. This model simultaneously explains all three observations: the UV emission-line flux decrease, the soft-excess increase, and the emission-line anomaly

Urban blue: A global analysis of the factors shaping people's perceptions of the marine environment and ecological engineering in harbours.

Marine harbours are the focus of a diverse range of activities and subject to multiple anthropogenically induced pressures. Support for environmental management options aimed at improving degraded harbours depends on understanding the factors which influence people's perceptions of harbour environments. We used an online survey, across 12 harbours, to assess sources of variation people's perceptions of harbour health and ecological engineering. We tested the hypotheses: 1) people living near impacted harbours would consider their environment to be more unhealthy and degraded, be more concerned about the environment and supportive of and willing to pay for ecological engineering relative to those living by less impacted harbours, and 2) people with greater connectedness to the harbour would be more concerned about and have greater perceived knowledge of the environment, and be more supportive of, knowledgeable about and willing to pay for ecological engineering, than those with less connectedness. Across twelve locations, the levels of degradation and modification by artificial structures were lower and the concern and knowledge about the environment and ecological engineering were greater in the six Australasian and American than the six European and Asian harbours surveyed. We found that people's perception of harbours as healthy or degraded, but not their concern for the environment, reflected the degree to which harbours were impacted. There was a positive relationship between the percentage of shoreline modified and the extent of support for and people's willingness to pay indirect costs for ecological engineering. At the individual level, measures of connectedness to the harbour environment were good predictors of concern for and perceived knowledge about the environment but not support for and perceived knowledge about ecological engineering. To make informed decisions, it is important that people are empowered with sufficient knowledge of the environmental issues facing their harbour and ecological engineering options

ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in three infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented in case reports and series to occupy a wider clinicopathologic spectrum with recurrent KIF5B-ALK fusions. The full clinicopathologic and molecular spectra of ALK-positive histiocytosis remain, however, poorly characterized. Here, we describe the largest study of ALK-positive histiocytosis to date, with detailed clinicopathologic data of 39 cases, including 37 cases with confirmed ALKrearrangements. The clinical spectrum comprised distinct clinical phenotypic groups: infants with multisystemic disease with liver and hematopoietic involvement, as originally described (Group 1A: 6/39), other patients with multisystemic disease (Group 1B: 10/39), and patients with single-system disease (Group 2: 23/39). Nineteen patients of the entire cohort (49%) had neurologic involvement (seven and twelve from Groups 1B and 2, respectively). Histology included classic xanthogranuloma features in almost one third of cases, whereas the majority displayed a more densely cellular, monomorphic appearance without lipidized histiocytes but sometimes more spindled or epithelioid morphology. Neoplastic histiocytes were positive for macrophage markers and often conferred strong expression of phosphorylated-ERK, confirming MAPK pathway activation. KIF5B-ALK fusions were detected in 27 patients, while CLTC-ALK, TPM3-ALK, TFG-ALK, EML4-ALK and DCTN1-ALK fusions were identified in single cases. Robust and durable responses were observed in 11/11 patients treated with ALK inhibition, ten with neurologic involvement. This study presents the existing clinicopathologic and molecular landscape of ALK-positive histiocytosis, and provides guidance for the clinical management of this emerging histiocytic entity.Molecular tumour pathology - and tumour genetic

Pathways to coastal resiliency: The Adaptive Gradients Framework

10.3390/su10082629Sustainability (Switzerland)108262

Space telescope and optical reverberation mapping project. I. Ultraviolet observations of the Seyfert 1 galaxy NGC 5548 with the cosmic origins spectrograph on <i>Hubble Space Telescope</i>

We describe the first results from a six-month long reverberation-mapping experiment in the ultraviolet based on 171 observations of the Seyfert 1 galaxy NGC 5548 with the Cosmic Origins Spectrograph on the Hubble Space Telescope. Significant correlated variability is found in the continuum and broad emission lines, with amplitudes ranging from ~30% to a factor of two in the emission lines and a factor of three in the continuum. The variations of all the strong emission lines lag behind those of the continuum, with He ii $\lambda 1640$ lagging behind the continuum by ~2.5 days and Lyα $\lambda 1215$, C iv $\lambda 1550$, and Si iv $\lambda 1400$ lagging by ~5–6 days. The relationship between the continuum and emission lines is complex. In particular, during the second half of the campaign, all emission-line lags increased by a factor of 1.3–2 and differences appear in the detailed structure of the continuum and emission-line light curves. Velocity-resolved cross-correlation analysis shows coherent structure in lag versus line of sight velocity for the emission lines; the high-velocity wings of C iv respond to continuum variations more rapidly than the line core, probably indicating higher velocity broad-line region clouds at smaller distances from the central engine. The velocity-dependent response of Lyα, however, is more complex and will require further analysis

In Situ Geochronology for the Next Decade: Mission Designs for the Moon, Mars, and Vesta

Geochronology is an indispensable tool for reconstructing the geologic history of planets, essential to understanding the formation and evolution of our solar system. Bombardment chronology bounds models of solar system dynamics, as well as the timing of volatile, organic, and siderophile element delivery. Absolute ages of magmatic products provide constraints on the dynamics of magma oceans and crustal formation, as well as the longevity and evolution of interior heat engines and distinct mantle/crustal source regions. Absolute dating also relates habitability markers to the timescale of evolution of life on Earth. However, the number of terrains important to date on worlds of the inner solar system far exceeds our ability to conduct sample return from all of them. In preparation for the upcoming Decadal Survey, our team formulated a set of medium-class (New Frontiers) mission concepts to three different locations (the Moon, Mars, and Vesta) where sites that record solar system bombardment, magmatism, and habitability are uniquely preserved and accessible. We developed a notional payload to directly date planetary surfaces, consisting of two instruments capable of measuring radiometric ages, an imaging spectrometer, optical cameras to provide site geologic context and sample characterization, a traceelement analyzer to augment sample contextualization, and a sample acquisition and handling system. Landers carrying this payload to the Moon, Mars, and Vesta would likely fit into the New Frontiers cost cap in our study (∼$1B). A mission of this type would provide crucial constraints on planetary history while also enabling a broad suite of complementary investigations 2021. The Author(s). Published by the American Astronomical Society. © 2021. The Author(s). Published by the American Astronomical Society.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Direct removal of SU-8 using focused laser writing

10.1007/s00339-006-3846-zApplied Physics A: Materials Science and Processing87171-76APAM