Food allergy is a cause of delayed physical development ininfants and pre­school children

In order to demonstrate the importance of food allergy in forming of delayed physical development were studiedfeatures history and feeding habits 120infants and pre-school children with low anthropometric characteristics and 40 children of the same age with normal physical development the control group included. We performed immunological tests and endoscopic examination of all these children. Concomitant allergic diseases were detected in children with physical disabilities (p<0,05), violated the order and quality of complementary foods in the first year of life.Deficiency of essential nutrientswas identifiedin the diet of children because ofintolerance to various foods(p<0,05). The presence of allergic inflammation in different parts of the gastrointestinal tractwas proved morphological study.С целью уточнения роли гастроинтестинальной пищевой аллергии в формировании хронических расстройств литания у детей, изучены особенности анамнеза, проанализирован рацион питания, проведено иммунологическое и эндоскопическое обследование 120 детей раннего и дошкольного возраста с отставанием в физическом развитии и 40 детей той же возрастной категории с нормальным физическим развитием, составивших группу сравнения. У детей с отставанием в физическом развитии достоверно чаще имели место сопутствующие аллергические заболевания (р<0,05), был наррен порядок и качество введения прикорма на первом году жизни. Выявлен дефицит всех основных питательных веществе рационе литания детей (р<0,05), обусловленный в большинстве случаев непереносимостью различных продуктов. Наличие аллергического воспаления в различных отделах желудочно-кишечного тракта подтверждено морфологически, в результате исследования биоптатов слизистой двенадцатиперстной кишки и прямой кишки

The clinico-neurologic characteristic and features of psychological development of children of the first year of the life with prenatal lesion cns on the background of the undifferentiated dysplasia of the connecting tissue

In clause data about features of current of the regenerative period and a condition of psychological development in children of the first year of a life with prenatal lesion CNS on a background of a undifferentiated dysplasia of a connecting tissue (UDCT) are presented. It is established, that attributes UDCT are taped at 51,1 % of children with prenatal lesion CNS. It is shown, that current of regenerative period prenatal lesion CNS at the designated contingent of babies is accompanied by retardation of rates of static-motor development, backlog of formation of skills of a fine motility and active speech.В статье представлены данные об особенностях течения восстановительного периода и состоянии нервно-психического развития у детей первого года жизни с перинатальным поражением ЦНС (ППЦНС) на фоне недифференцированной дисплазии соединительной ткани (НДСТ). Установлено, что признаки НДСТ выявляются у 51,1% детей с ППЦНС. Показано, что течение восстановительного периода ППЦНС у обозначенного контингента младенцев сопровождается замедлением темпов статико-моторного развития, отставанием формирования навыков мелкой моторики и активной речи

The characteristic of psychological deviations at children of three-year age with residual phenomena of perinatal lesion CNS

In article the data on features of psychological deviations at children of 3 years with residual phenomena of prenatal lesion of CNS hypoxi-ischemic genesis are submitted. It is shown, that at 73,95 % of children are revealed nonpsychotic mental frustration residual-organic genesis. It is shown, that at children, suffered from prenatal software CNS and having mental deviations are observed backlog of formation of a fine and rough motility, becoming of skills of self-service, skills, role games, speech development. Authentically low parameters of the social competence, adaptive behaviour, conformity of verbal intelligence nonverbal are revealed in comparison with children without mental infringements.В статье представлены данные об особенностях нервно-психических отклонений у детей 3 лет с резидуальными явлениями ПП ЦНС гипоксически-ишемического генеза. Показано, что у 73,95% детей выявлены непсихотические психические расстройства резидуально-органического генеза. Показано, что у детей, перенесших ПП ЦНС и имеющих психические отклонения наблюдаются отставание формирования мелкой и грубой моторики, становления навыков самообслуживания, умений, ролевых игр, речевого развития. Выявлены достоверно низкие показатели социальной компетенции, адаптивного поведения, соответствия вербального интеллекта невербальному по сравнению с детьми без психических нарушений

Analysis of the causes of delayed physical development in infants and pre­school children

In order to identify of the causes of delayed physical development were studied features history and feeding habits 120 infants and pre-school children with low anthropometric characteristics and 40 children of the same age with normal physical development the control group included. Consequences of perinatal lesions of the central nervous system were detected in children with physical disabilities (p<0,05). Deficiency of essential nutrients was identified in the diet of children because of intolerance to various foods(p<0,05).С целью определения причин, приводящих к отставанию в физическом развитии, изучены особенности анамнеза и рациона питания 120 детей раннего и дошкольного возраста с низкими антропометрическими показателями и 40 детей той же возрастной категории с нормальным физическим развитием, составивших группу сравнения. Достоверно чаще выявлялись последствия перинатального поражения центральной нервной системы у детей с отставанием в физическом развитии (р<0,05). Выявлен дефицит основных питательных веществ в рационе питания детей (р<0,05), обусловленный в большинстве случаев непереносимостью различных продуктов питания

Type 1 diabetes in the mother as a risk factor disorders of health infants and young children (review)

The paper presents the literature data on the effect of type 1 diabetes in the mother during gestation, fetal development, health and adaptation features of infants and young children.В статье представлены литературные данные о влиянии сахарного диабета 1 типа матери на течение гестационного периода, внутриутробное развитие, состояние здоровья и особенности адаптации детей младенческого и раннего возраста

COMPARISON OF EFFICACY AND SAFETY OF RAMIPRIL, MOLSIDOMINE AND THEIR COMBINATION IN PATIENTS WITH CHRONIC HEART FAILURE, WHICH COMPLICATED ISCHEMIC HEART DISEASE

Aim. To study effects of ramipril, molsidomine and their combinations on morphofunctional heart indices and clinical status of patients with chronic heart failure (CHF), which complicated an ischemic heart disease (IHD).Material and methods. 41 patients with CHF class II-III (NYHA), which complicated IHD (postinfarction cardiosclerosis) were included in the study. Patients did not receive ACE inhibitors. Patients were split in 3 groups: patients of the 1st group received ramipril, patients of the 2nd group - molsidomine and patients of the 3rd group – combination of ramipril and molsidomine. Clinical examination, laboratory tests, electrocardiogram, cardiac ultrasonograthy, exercise tolerance test was performed before treatment and after 3 months and 1 year of treatment.Results. Improvement of clinical status and decrease of class NYHA was found in 38,5% of patients in ramipril group; in 33,3% of patients in molsidomine group and in 23,1 % of patients in combined therapy group. Increase of ejection fraction on 17 % from initial level was found in patients receiving combined therapy; on 25,2% - in patients receiving molsidomine; and on 12,4% - in patients receiving ramipril. Decrease of residual volumes of a left ventricle also was detected.Conclusion. All therapies (ramipril, molsidomine and their combination) in patients with CHF class II-III and postinfarction cardiosclerosis are clinically and hemodynamically effective in long term implementation

CHARGE syndrome

The article provides literature data and description of the clinical case of CHARGE syndrome with an autosomal – dominant type of inheritance in a child of 3 years and 7 months. The name of the syndrome is formed by the first letters of the characteristic congenital malformations: “C” (coloboma) – optic disc coloboma, “H” (heart defects) – cardiovascular abnormalities, “A” (atresia of choanae) – atresia or stenosis of choan, “R” (retardation of growth and development) – growth deficit, developmental delay, “G” (genital anomalies) – genital anomalies, “E” (ear abnormalities and sensorineural hearing loss) – hearing organ abnormalities. A feature of the clinical case is the early diagnosis of CHARGE syndrome, manifested by bilateral optic disc coloboma; unilateral paresis of the facial nerve; congenital heart disease (open aortic duct); retardation of growth, psychomotor and psycho-speech development; cryptorchidism; bilateral anomaly of the outer ear (short, wide, absence of the lobe and external curl), sensorineural hearing loss; bilateral renal hypopalasia, chronic kidney disease

ACHIEVEMENT OF TARGET BLOOD PRESSURE LEVEL IN HYPERTENSIVE PATIENTS WITH AMLODIDINE: ORIGINAL DRUG VERSUS GENERIC

Aim. To evaluate antihypertensive effects of new generic amlodipine (Stamlo M) in comparison with original amlodipine (Norvasc) in monotherapy and in combination with angiotensin converting enzyme (ACE) inhibitor and diuretic in patients with arterial hypertension (HT) of 1-2 degree.Material and methods. 60 patients with HT of 1-2 degree were included in the open randomized parallel comparative study. Patients were split into 2 groups. Study duration was 10 weeks. Efficacy control, dose correction, addition of ACE inhibitor and diuretic was performed each 2 weeks.Results. The significant antihypertensive effect of monotherapy was observed in both groups already by the 2-4 weeks of therapy. Significant differences between amlodipines in influence on blood pressure (BP) level and heart rate was not found. Monotherapy with generic amlodipine (10 mg OD) provided target BP level more than in half of patients. Achievement of target BP levels was found in 89% and 96% of patients treated with generic and original amlodipine, respectively, when they were combined with lisinopril (10 mg OD) and hydrochlorothiazide (12,5 mg OD).Conclusion. New generic amlodipine (Stamlo M) is an effective and safe antihypertensive drug comparable with original amlodipine in clinical efficacy