Choroid plexus volume in multiple sclerosis vs neuromyelitis optica spectrum disorder: a retrospective, cross-sectional analysis

BACKGROUND AND OBJECTIVES: The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the choroid plexus is similarly involved in MS and in neuromyelitis optica spectrum disorder (NMOSD). Thus, the aim of this study was to compare the choroid plexus volume in MS and NMOSD. METHODS: In this retrospective, cross-sectional study, patients were included by convenience sampling from 4 international MS centers. The choroid plexus of the lateral ventricles was segmented fully automatically on T1-weighted MRI sequences using a deep learning algorithm (Multi-Dimensional Gated Recurrent Units). Uni- and multivariable linear models were applied to investigate associations between the choroid plexus volume, clinically meaningful disease characteristics, and MRI parameters. RESULTS: We studied 180 patients with MS and 98 patients with NMOSD. In total, 94 healthy individuals and 47 patients with migraine served as controls. The choroid plexus volume was larger in MS (median 1,690 µL, interquartile range [IQR] 648 µL) than in NMOSD (median 1,403 µL, IQR 510 µL), healthy individuals (median 1,533 µL, IQR 570 µL), and patients with migraine (median 1,404 µL, IQR 524 µL; all p < 0.001), whereas there was no difference between NMOSD, migraine, and healthy controls. This was also true when adjusted for age, sex, and the intracranial volume. In contrast to NMOSD, the choroid plexus volume in MS was associated with the number of T2-weighted lesions in a linear model adjusted for age, sex, total intracranial volume, disease duration, relapses in the year before MRI, disease course, Expanded Disability Status Scale score, disease-modifying treatment, and treatment duration (beta 4.4; 95% CI 0.78-8.1; p = 0.018). DISCUSSION: This study supports an involvement of the choroid plexus in MS in contrast to NMOSD and provides clues to better understand the respective pathogenesis

Estimating the Ultimate Recoverable Reserves of the Paris Basin, France

The Paris Basin is a mature basin from an exploration point of view. More than 800 exploration wells have been drilled over the last 40 years and 52 fields have been discovered from which 33. 4 Mt of petroleum have been produced by the end 2000. Based on past production data, the future exploration and production potential of the Paris Basin is estimated using classical statistical methods. The mean size of a field in theParis Basin is about 100 000 t with a 5% chance of a field whose size is greater than 2. 5 Mt. The ultimate recoverable reserves based on the creaming curve analysis were about 15 Mt in 1986, 29 Mt in 1991 and 46 Mt in 1996. At present, there is a 5% chance of finding a field in the Dogger and Keuper formations that is bigger than 4 Mt. The drilling success ratio increases from 1/66 for the shallowest, the Cretaceous Neocomian formation to 1/8 in the deepest and latest to be drilled Triassic Keuper formation. The data analysis presented in the paper is based on known production data which do not take into account additional production gained by enhanced recovery methods or additional reserves added by discoveries based on new plays, that however may significantly increase reserves beyond the numbers presented here as the creaming curve analysis has shown