Selected tether applications in space: Phase 2. Executive summary

The application of tether technology has the potential to increase the overall performance efficiency and capability of the integrated space operations and transportation systems through the decade of the 90s. The primary concepts for which significant economic benefits were identified are dependent on the space station as a storage device for angular momentum and as an operating base for the tether system. Concepts examined include: (1) tether deorbit of shuttle from space station; (2) tethered orbit insertion of a spacecraft from shuttle; (3) tethered platform deployed from space station; (4) tether-effected rendezvous of an OMV with a returning OTV; (5) electrodynamic tether as an auxiliary power source for space station; and (6) tether assisted launch of an OTV mission from space station

Use of Electroshock for Euthanizing and Immobilizing Adult Spring Chinook Salmon in a Hatchery

This study evaluated the use of electroshock as in alternative to traditional techniques for immobilizing and euthanizing hatchery fish. We used a commercially available electroanesthesia unit at the U.S. Fish and Wildlife Service\u27s Carson National Fish Hatchery (Carson, Washington) to euthanize adult spring Chinook salmon Oncorhynchus tshawytscha and to son and collect gametes of fish at maturation. During euthanization by electroshock, the response of each fish was observed, Muscular and vertebral hemorrhaging wits quantified, and electrical settings were optimized accordingly. During gamete collection, fish were either electroshocked or exposed to tricaine methanesulfortate (MS-222); hemorrhaging, egg viability. egg size and quantity, and resultant fry quality were examined for each treatment group. Electroshocked fish had a higher likelihood Of injury during gamete collection than did fish exposed to MS-222. On average, each electroshocked fish had less than two hemorrhages oil both fillets examined. The size of each hemorrhage was less than 0.10% of the fillet surface. Fecundity and egg and fry quality were not affected by either immobilization method. Electroshock was a viable and efficient means of euthanizing adult spring Chinook salmon or sorting the fish and collecting their gametes. However, equipment settings must be optimized based on site-specific (e.g., water conductivity) and species-specific (e.g., fish size and seasonal state of maturation) factors

Racial Preferences, Racial Awareness, and Racial Identification of Native American Children

Psycholog

Multi-serotype pneumococcal nasopharyngeal carriage prevalence in vaccine naïve Nepalese children, assessed using molecular serotyping.

Invasive pneumococcal disease is one of the major causes of death in young children in resource poor countries. Nasopharyngeal carriage studies provide insight into the local prevalence of circulating pneumococcal serotypes. There are very few data on the concurrent carriage of multiple pneumococcal serotypes. This study aimed to identify the prevalence and serotype distribution of pneumococci carried in the nasopharynx of young healthy Nepalese children prior to the introduction of a pneumococcal conjugate vaccine using a microarray-based molecular serotyping method capable of detecting multi-serotype carriage. We conducted a cross-sectional study of healthy children aged 6 weeks to 24 months from the Kathmandu Valley, Nepal between May and October 2012. Nasopharyngeal swabs were frozen and subsequently plated on selective culture media. DNA extracts of plate sweeps of pneumococcal colonies from these cultures were analysed using a molecular serotyping microarray capable of detecting relative abundance of multiple pneumococcal serotypes. 600 children were enrolled into the study: 199 aged 6 weeks to <6 months, 202 aged 6 months to < 12 months, and 199 aged 12 month to 24 months. Typeable pneumococci were identified in 297/600 (49.5%) of samples with more than one serotype being found in 67/297 (20.2%) of these samples. The serotypes covered by the thirteen-valent pneumococcal conjugate vaccine were identified in 44.4% of samples containing typeable pneumococci. Application of a molecular serotyping approach to identification of multiple pneumococcal carriage demonstrates a substantial prevalence of co-colonisation. Continued surveillance utilising this approach following the introduction of routine use of pneumococcal conjugate vaccinates in infants will provide a more accurate understanding of vaccine efficacy against carriage and a better understanding of the dynamics of subsequent serotype and genotype replacement

Support, networks, and relationships: Findings from a mixed-methods evaluation of a mentorship programme for early career women researchers in sexual and reproductive health and rights

Low research output among women researchers in health research has been linked to inadequate mentorship opportunities for early career women researchers and particularly in sexual and reproductive health and rights (SRHR) field. Mentorship has been recognized as a contributor to strengthening research capacity and as beneficial for both mentors and mentees. Women researchers oftentimes experience negative impacts of organizational and structural gender inequities related to formal and informal mentoring. In 2020, the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction at WHO launched a mentorship programme for early career SRHR women researchers from low- and middle-income countries. The programme sought to provide professional skill-building, promote and share networking opportunities, and offer support in navigating personal and professional life. We conducted a convergent parallel mixed-methods evaluation of the 2020 pilot programme, which included 26 participants, through an online survey and semi-structured in-depth interviews (IDIs). Data collection occurred between March and May 2022. Nineteen responded to the online survey (12 mentees, 7 mentors) and 11 IDIs (7 mentees, 4 mentors) were completed. Based on a preliminary framework, we used deductive and inductive methods to identify six themes: views on mentorship; reasons for applying and expectations of participation in the programme; preferred aspects of programme implementation; challenges with the programme implementation; perceived lasting benefits of the programme; and recommendations for improvement. All participants found the initial training useful, most discussed work-life prioritization throughout the mentorship relationship, and most planned to continue with the relationship. There appear to be ample benefits to mentorship, especially when planned and implemented in a structured manner. These attributes can be particularly beneficial when they are conceived as a two-way relationship of mutual learning and support, and especially for women at the start of their research careers as they navigate structural gender inequities

Serotype-specific correlates of protection for pneumococcal carriage: an analysis of immunity in 19 countries.

Background: Pneumococcal conjugate vaccines (PCVs) provide direct protection against disease in those vaccinated, and interrupt transmission through the prevention of nasopharyngeal carriage. Methods: We analysed immunogenicity data from 5224 infants who received PCV in prime-boost schedules. We defined any increase in antibody between the one-month post-priming visit and the booster dose as an indication of nasopharyngeal carriage ('seroincidence'). We calculated antibody concentrations using receiver-operator characteristic curves, and used generalised additive models to compute their protective efficacy against seroincidence. To support seroincidence as a marker of carriage, we compared seroincidence in a randomised immunogenicity trial in Nepal with the serotype-specific prevalence of carriage in the same community. Findings: In Nepalese infants, seroincidence of carriage closely correlated with serotype-specific carriage prevalence in the community. In the larger data set, antibody concentrations associated with seroincidence were lowest for serotypes 6B and 23F (0.50 µg/mL and 0.63 µg/mL respectively), and highest for serotypes 19F and 14 (2.54 µg/mL and 2.48 µg/mL respectively). The protective efficacy of antibody at these levels was 62% and 74% for serotypes 6B and 23F, and 87% and 84% for serotypes 19F and 14. Protective correlates were on average 2.15 times higher in low/lower middle income countries than in high/upper middle income countries (GMR 2.15, 95%CI 1.46-3.17, p=0.0024). Interpretation: Antibody concentrations associated with protection vary between serotypes. Higher antibody concentrations are required for protection in low-income countries. These findings are important for global vaccination policy, to interrupt transmission by protecting against carriage

Temporal Interferometry: A Mechanism for Controlling Qubit Transitions During Twisted Rapid Passage with Possible Application to Quantum Computing

In an adiabatic rapid passage experiment, the Bloch vector of a two-level system (qubit) is inverted by slowly inverting an external field to which it is coupled, and along which it is initially aligned. In twisted rapid passage, the external field is allowed to twist around its initial direction with azimuthal angle $\phi (t)$ at the same time that it is inverted. For polynomial twist: $\phi (t) \sim Bt^{n}$. We show that for $n \geq 3$, multiple avoided crossings can occur during the inversion of the external field, and that these crossings give rise to strong interference effects in the qubit transition probability. The transition probability is found to be a function of the twist strength $B$, which can be used to control the time-separation of the avoided crossings, and hence the character of the interference. Constructive and destructive interference are possible. The interference effects are a consequence of the temporal phase coherence of the wavefunction. The ability to vary this coherence by varying the temporal separation of the avoided crossings renders twisted rapid passage with adjustable twist strength into a temporal interferometer through which qubit transitions can be greatly enhanced or suppressed. Possible application of this interference mechanism to construction of fast fault-tolerant quantum CNOT and NOT gates is discussed.Comment: 29 pages, 16 figures, submitted to Phys. Rev.

How healthcare providers’ own death anxiety influences their communication with patients in end-of-life care: A thematic analysis

Healthcare providers’ own death anxiety can influence end-of-life communication. We interviewed nine palliative care health providers about their experiences of providing end-of-life care. Participants also completed the Revised Death Anxiety Scale. A thematic analysis of the interview transcripts identified one theme labelled ‘avoidant coping’ and another labelled ‘death anxiety awareness’, which are presented in the context of the participants’ own Revised Death Anxiety Scale scores. The findings show that avoidant death anxiety coping can compromise end-of-life communication, but that greater awareness of death anxiety can help overcome avoidant coping. The findings can inform potential improvements in healthcare practice and training.N/

Understanding the ability of low-cost MOx sensors to quantify ambient VOCs

Volatile organic compounds (VOCs) present a unique challenge in air quality research given their importance to human and environmental health, and their complexity to monitor resulting from the number of possible sources and mixtures. New technologies, such as low-cost air quality sensors, have the potential to support existing air quality measurement methods by providing data in high time and spatial resolution. These higher-resolution data could provide greater insight into specific events, sources, and local variability. Furthermore, given the potential for differences in selectivities for sensors, leveraging multiple sensors in an array format may even be able to provide insight into which VOCs or types of VOCs are present. During the FRAPPE and DISCOVER-AQ monitoring campaigns, our team was able to co-locate two sensor systems, using metal oxide (MOx) VOC sensors, with a proton-transfer-reaction quadrupole mass spectrometer (PTR-QMS) providing speciated VOC data. This dataset provided the opportunity to explore the ability of sensors to estimate specific VOCs and groups of VOCs in real-world conditions, e.g., dynamic temperature and humidity. Moreover, we were able to explore the impact of changing VOC compositions on sensor performance as well as the difference in selectivities of sensors in order to consider how this could be utilized. From this analysis, it seems that systems using multiple VOC sensors are able to provide VOC estimates at ambient levels for specific VOCs or groups of VOCs. It also seems that this performance is fairly robust in changing VOC mixtures, and it was confirmed that there are consistent and useful differences in selectivities between the two MOx sensors studied. While this study was fairly limited in scope, the results suggest that there is the potential for low-cost VOC sensors to support highly resolved ambient hydrocarbon measurements. The availability of this technology could enhance research and monitoring for public health and communities impacted by air toxics, which in turn could support a better understanding of exposure and actions to reduce harmful exposure.</p