NGC 4138 - A Case Study in Counterrotating Disk Formation

The Sa(r) galaxy NGC 4138 has been recently found to contain an extensive counterrotating disk which appears to be still forming. Up to a third of the stars in the disk system may be on retrograde orbits. A counterrotating ring of H II regions, along with extended counterrotating H I gas, suggests that the retrograde material has been recently acquired in the gas phase and is still trickling in. Using numerical simulations, we have attempted to model the process by which the counterrotating mass has been accreted by this galaxy. We investigate two possibilities: continuous retrograde infall of gas, and a retrograde merger with a gas-rich dwarf galaxy. Both processes are successful in producing a counterrotating disk of the observed mass and dimensions without heating up the primary significantly. Contrary to our experience with a fiducial cold, thin primary disk, the gas-rich merger works well for the massive, compact primary disk of NGC 4138 even though the mass of the dwarf galaxy is a significant fraction of the mass of the primary disk. Although we have restricted ourselves mainly to coplanar infall and mergers, we report on one inclined infall simulation as well. We also explore the possibility that the H-alpha ring seen in the inner half of the disk is a consequence of counterrotating gas clouds colliding with corotating gas already present in the disk and forming stars in the process.Comment: To appear in ApJ, 21 pages, LaTeX (aaspp4) format, 17 figs (gzipped tar file) also available at ftp://bessel.mps.ohio-state.edu/pub/thakar/cr2/ or at http://www-astronomy.mps.ohio-state.edu/~thakar

Running a distributed virtual observatory: US Virtual Astronomical Observatory operations

Operation of the US Virtual Astronomical Observatory shares some issues with modern physical observatories, e.g., intimidating data volumes and rapid technological change, and must also address unique concerns like the lack of direct control of the underlying and scattered data resources, and the distributed nature of the observatory itself. In this paper we discuss how the VAO has addressed these challenges to provide the astronomical community with a coherent set of science-enabling tools and services. The distributed nature of our virtual observatory-with data and personnel spanning geographic, institutional and regime boundaries-is simultaneously a major operational headache and the primary science motivation for the VAO. Most astronomy today uses data from many resources. Facilitation of matching heterogeneous datasets is a fundamental reason for the virtual observatory. Key aspects of our approach include continuous monitoring and validation of VAO and VO services and the datasets provided by the community, monitoring of user requests to optimize access, caching for large datasets, and providing distributed storage services that allow user to collect results near large data repositories. Some elements are now fully implemented, while others are planned for subsequent years. The distributed nature of the VAO requires careful attention to what can be a straightforward operation at a conventional observatory, e.g., the organization of the web site or the collection and combined analysis of logs. Many of these strategies use and extend protocols developed by the international virtual observatory community.Comment: 7 pages with 2 figures included within PD

SPH Simulations of Counterrotating Disk Formation in Spiral Galaxies

We present the results of Smoothed Particle Hydrodynamics (SPH) simulations of the formation of a massive counterrotating disk in a spiral galaxy. The current study revisits and extends (with SPH) previous work carried out with sticky particle gas dynamics, in which adiabatic gas infall and a retrograde gas-rich dwarf merger were tested as the two most likely processes for producing such a counterrotating disk. We report on experiments with a cold primary similar to our Galaxy, as well as a hot, compact primary modeled after NGC 4138. We have also conducted numerical experiments with varying amounts of prograde gas in the primary disk, and an alternative infall model (a spherical shell with retrograde angular momentum). The structure of the resulting counterrotating disks is dramatically different with SPH. The disks we produce are considerably thinner than the primary disks and those produced with sticky particles. The time-scales for counterrotating disk formation are shorter with SPH because the gas loses kinetic energy and angular momentum more rapidly. Spiral structure is evident in most of the disks, but an exponential radial profile is not a natural byproduct of these processes. The infalling gas shells that we tested produce counterrotating bulges and rings rather than disks. The presence of a considerable amount of preexisting prograde gas in the primary causes, at least in the absence of star formation, a rapid inflow of gas to the center and a subsequent hole in the counterrotating disk. In general, our SPH experiments yield stronger evidence to suggest that the accretion of massive counterrotating disks drives the evolution of the host galaxies towards earlier (S0/Sa) Hubble types.Comment: To appear in ApJ. 20 pages LaTex 2-column with 3 tables, 23 figures (GIF) available at this site. Complete gzipped postscript preprint with embedded figures available from http://tarkus.pha.jhu.edu/~thakar/cr3.html (3 Mb

Pathfinder cells provide a novel therapeutic intervention for acute kidney injury

Pathfinder cells (PCs) are a novel class of adult-derived cells that facilitate functional repair of host tissue. We used rat PCs to demonstrate that they enable the functional mitigation of ischemia reperfusion (I/R) injury in a mouse model of renal damage. Female C57BL/6 mice were subjected to 30 min of renal ischemia and treated with intravenous (i.v.) injection of saline (control) or male rat pancreas-derived PCs in blinded experimentation. Kidney function was assessed 14 days after treatment by measuring serum creatinine (SC) levels. Kidney tissue was assessed by immunohistochemistry (IHC) for markers of cellular damage, proliferation, and senescence (TUNEL, Ki67, p16ink4a, p21). Fluorescence in situ hybridization (FISH) was performed to determine the presence of any rat (i.e., pathfinder) cells in the mouse tissue. PC-treated animals demonstrated superior renal function at day 14 post-I/R, in comparison to saline-treated controls, as measured by SC levels (0.13 mg/dL vs. 0.23 mg/dL, p<0.001). PC-treated kidney tissue expressed significantly lower levels of p16ink4a in comparison to the control group (p=0.009). FISH analysis demonstrated that the overwhelming majority of repaired kidney tissue was mouse in origin. Rat PCs were only detected at a frequency of 0.02%. These data confirm that PCs have the ability to mitigate functional damage to kidney tissue following I/R injury. Kidneys of PC-treated animals showed evidence of improved function and reduced expression of damage markers. The PCs appear to act in a paracrine fashion, stimulating the host tissue to recover functionally, rather than by differentiating into renal cells. This study demonstrates that pancreatic-derived PCs from the adult rat can enable functional repair of renal damage in mice. It validates the use of PCs to regenerate damaged tissues and also offers a novel therapeutic intervention for repair of solid organ damage in situ

Make Research Data Public? -- Not Always so Simple: A Dialogue for Statisticians and Science Editors

Putting data into the public domain is not the same thing as making those data accessible for intelligent analysis. A distinguished group of editors and experts who were already engaged in one way or another with the issues inherent in making research data public came together with statisticians to initiate a dialogue about policies and practicalities of requiring published research to be accompanied by publication of the research data. This dialogue carried beyond the broad issues of the advisability, the intellectual integrity, the scientific exigencies to the relevance of these issues to statistics as a discipline and the relevance of statistics, from inference to modeling to data exploration, to science and social science policies on these issues.Comment: Published in at http://dx.doi.org/10.1214/10-STS320 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth

Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of cells and often focus on the initial phase of the infection. Here, we used a combination of experiments and mathematical modelling to investigate the network of immune responses against single and co-infections with the respiratory bacterium Bordetella bronchiseptica and the gastrointestinal helminth Trichostrongylus retortaeformis. Our goal was to identify representative mediators and functions that could capture the essence of the host immune response as a whole, and to assess how their relative contribution dynamically changed over time and between single and co-infected individuals. Network-based discrete dynamic models of single infections were built using current knowledge of bacterial and helminth immunology; the two single infection models were combined into a co-infection model that was then verified by our empirical findings. Simulations showed that a T helper cell mediated antibody and neutrophil response led to phagocytosis and clearance of B. bronchiseptica from the lungs. This was consistent in single and co-infection with no significant delay induced by the helminth. In contrast, T. retortaeformis intensity decreased faster when co-infected with the bacterium. Simulations suggested that the robust recruitment of neutrophils in the co-infection, added to the activation of IgG and eosinophil driven reduction of larvae, which also played an important role in single infection, contributed to this fast clearance. Perturbation analysis of the models, through the knockout of individual nodes (immune cells), identified the cells critical to parasite persistence and clearance both in single and co-infections. Our integrated approach captured the within-host immuno-dynamics of bacteria-helminth infection and identified key components that can be crucial for explaining individual variability between single and co-infections in natural populations