Feasibility study of a synthesis procedure for array feeds to improve radiation performance of large distorted reflector antennas

Virginia Tech has several activities which support the NASA Langley effort in the area of large aperture radiometric antenna systems. This semi-annual report discusses the major areas of research and progress made

Feasibility study of a synthesis procedure for array feeds to improve radiation performance of large distorted reflector antennas

The topics covered include the following: (1) performance analysis of the Gregorian tri-reflector; (2) design and performance of the type 6 reflector antenna; (3) a new spherical main reflector system design; (4) optimization of reflector configurations using physical optics; (5) radiometric array design; and (7) beam efficiency studies

Feasibility study of a synthesis procedure for array feeds to improve radiation performance of large distorted reflector antennas

There were several tangible products that resulted from the reflector antenna research program. The initial technical effort was to develop techniques to compensate for distortions over the surface of the main reflector of a large reflector antenna system. An in-depth investigation of this problem resulted in a new technique for the electronic correction of surface errors. A journal article on the findings describe the use of the iterative sampling method. Shortly after the 'Mission to Planet Earth' program started, we began investigating the use of large reflector antennas in geostationary orbit for passive earth remote sensing. A study panel was coordinated by Virginia Tech to set technical goals for the effort. These were used to guide the design of several antennas. The original interest stemmed from an industrial (Reynolds Metals) need and currently involves work with industry (Prodelin Corporation) on high technology, low cost reflectors. The intervening years (1987 - 1993) is the period of this report and Virginia Tech's reflector antenna activity then was exclusively with NASA LaRC

Feasibility study of a synthesis procedure for array feeds to improve radiation performance of large distorted reflector antennas

The manpower on this effort was reduced during this reporting period. Activity in the past six months is summarized. The Type 1 antenna is complete and documentation is in final phases. The Type 2 antenna design is complete and a journal article was prepared and was accepted for publication in EEE Transactions on Antennas and Propagation. The spherical antenna configurations are complete and a journal article will appear in the June 1993 issue of EEE Transactions on Antennas and Propagation. In addition, a patent for the spherical antenna is being pursued. The final current activity is that of optimization techniques and they are approaching completion as well. The Tri-Reflector synthesis code (TSAP) was put into user friendly format. A user's guide (Report 93-13) was written and distributed to LaRC. Work continues on EASY7. EASY7 is a user friendly code used to create an input file to GRASP7

Feasibility study of a synthesis procedure for array feeds to improve radiation performance of large distorted reflector antennas

The following subject areas are covered: General Reflector Antenna Systems Program version 7(GRASP7); Multiple Reflector Analysis Program for Cylindrical Antennas (MRAPCA); Tri-Reflector 2D Synthesis Code (TRTDS); a geometrical optics and a physical optics synthesis techniques; beam scanning reflector, the type 2 and 6 reflectors, spherical reflector, and multiple reflector imaging systems; and radiometric array design

The 2000 outburst of the recurrent nova CI Aquilae: optical spectroscopy

We present low- and medium resolution spectra of the recurrent nova CI Aquilae taken at 14 epochs in May and June, 2000. The overall appearance is similar to other U Sco-type recurrent novae (U Sco, V394 CrA). Medium resolution (R=7000-10000) hydrogen and iron profiles suggest an early expansion velocity of 2000-2500 km/s. The H\alpha evolution is followed from Dt = -0.6 d to +53 d, starting from a nearly Gaussian shape to a double peaked profile through strong P-Cyg profiles. The interstellar component of the sodium D line and two diffuse interstellar bands put constraints on the interstellar reddening which is estimated to be E(B-V)=0.85\pm0.3. The available visual and CCD-V observations are used to determine t0,t2 and t3. The resulting parameters are: t0=2451669.5\pm0.1, t2=30\pm1 d, t3=36\pm1 d. The recent lightcurve is found to be generally similar to that observed in 1917 with departures as large as 1-2 mag in certain phases. This behaviour is also typical for the U Sco subclass.Comment: 8 pages, 7 figures, accepted for publication in A&

Discovery of a New Deeply Eclipsing SU UMa-Type Dwarf Nova, IY UMa (= TmzV85)

We discovered a new deeply eclipsing SU UMa-type dwarf nova, IY UMa, which experienced a superoutburst in 2000 January. Our monitoring revealed two distinct outbursts, which suggest a superoutburst interval of ~800 d, or its half, and an outburst amplitude of 5.4 mag. From time-series photometry during the superoutburst, we determined a superhump and orbital period of 0.07588 d and 0.0739132 d, respectively.Comment: 5 pages, 3 figures, accepted by PASJ lette

An integrated atom-photon junction

Photonic chips that integrate guides, switches, gratings and other components, process vast amounts of information rapidly on a single device. A new branch of this technology becomes possible if the light is coupled to cold atoms in a junction of small enough cross section, so that small numbers of photons interact appreciably with the atoms. Cold atoms are among the most sensitive of metrological tools and their quantum nature also provides a basis for new information processing methods. Here we demonstrate a photonic chip which provides multiple microscopic junctions between atoms and photons. We use the absorption of light at a junction to reveal the presence of one atom on average. Conversely, we use the atoms to probe the intensity and polarisation of the light. Our device paves the way for a new type of chip with interconnected circuits of atoms and photons.Comment: 5 pages, 4 figure. Submitted to Nature Photonic

An Assessment of the Use of Chimpanzees in Hepatitis C Research Past, Present and Future: 1. Validity of the Chimpanzee Model

The USA is the only significant user of chimpanzees in biomedical research in the world, since many countries have banned or limited the practice due to substantial ethical, economic and scientific concerns. Advocates of chimpanzee use cite hepatitis C research as a major reason for its necessity and continuation, in spite of supporting evidence that is scant and often anecdotal. This paper examines the scientific and ethical issues surrounding chimpanzee hepatitis C research, and concludes that claims of the necessity of chimpanzees in historical and future hepatitis C research are exaggerated and unjustifiable, respectively. The chimpanzee model has several major scientific, ethical, economic and practical caveats. It has made a relatively negligible contribution to knowledge of, and tangible progress against, the hepatitis C virus compared to non-chimpanzee research, and must be considered scientifically redundant, given the array of alternative methods of inquiry now available. The continuation of chimpanzee use in hepatitis C research adversely affects scientific progress, as well as chimpanzees and humans in need of treatment. Unfounded claims of its necessity should not discourage changes in public policy regarding the use of chimpanzees in US laboratories

miRNA signature associated with outcome of gastric cancer patients following chemotherapy

<p>Abstract</p> <p>Background</p> <p>Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful biomarkers that help guide individualized therapy for cancer because microRNA expression is dysregulated in cancer. In order to identify miRNA signatures for gastric cancer and for predicting clinical resistance to cisplatin/fluorouracil (CF) chemotherapy, a comprehensive miRNA microarray analysis was performed using endoscopic biopsy samples.</p> <p>Methods</p> <p>Biopsy samples were collected prior to chemotherapy from 90 gastric cancer patients treated with CF and from 34 healthy volunteers. At the time of disease progression, post-treatment samples were additionally collected from 8 clinical responders. miRNA expression was determined using a custom-designed Agilent microarray. In order to identify a miRNA signature for chemotherapy resistance, we correlated miRNA expression levels with the time to progression (TTP) of disease after CF therapy.</p> <p>Results</p> <p>A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (<it>P</it><0.05). Prominent among the upregulated miRNAs associated with chemosensitivity were miRNAs known to regulate apoptosis, including let-7g, miR-342, miR-16, miR-181, miR-1, and miR-34. When this 58-miRNA predictor was applied to a separate set of pre- and post-treatment tumor samples from the 8 clinical responders, all of the 8 pre-treatment samples were correctly predicted as low-risk, whereas samples from the post-treatment tumors that developed chemoresistance were predicted to be in the high-risk category by the 58 miRNA signature, suggesting that selection for the expression of these miRNAs occurred as chemoresistance arose.</p> <p>Conclusions</p> <p>We have identified 1) a miRNA expression signature that distinguishes gastric cancer from normal stomach epithelium from healthy volunteers, and 2) a chemoreresistance miRNA expression signature that is correlated with TTP after CF therapy. The chemoresistance miRNA expression signature includes several miRNAs previously shown to regulate apoptosis <it>in vitro</it>, and warrants further validation.</p