Drag and inertia coefficients for horizontally submerged rectangular cylinders in waves and currents

The results of an experimental investigation carried out to measure combined wave and current loads on horizontally submerged square and rectangular cylinders are reported in this paper. The wave and current induced forces on a section of the cylinders with breadth-depth (aspect) ratios equal to 1, 0.5, and 0.75 are measured in a wave tank. The maximum value of Keulegan-Carpenter (KC) number obtained in waves alone is about 5 and Reynolds (Re) number ranged from 6.3976103 to 1.186105. The drag (CD) and inertia (CM) coefficients for each cylinder are evaluated using measured sectional wave forces and particle kinematics calculated from linear wave theory. The values of CD and CM obtained for waves alone have already been reported (Venugopal, V., Varyani, K. S., and Barltrop, N. D. P. Wave force coefficients for horizontally submerged rectangular cylinders. Ocean Engineering, 2006, 33, 11-12, 1669-1704) and the coefficients derived in combined waves and currents are presented here. The results indicate that both drag and inertia coefficients are strongly affected by the presenceof the current and show different trends for different cylinders. The values of the vertical component inertia coefficients (CMY) in waves and currents are generally smaller than the inertia coefficients obtained in waves alone, irrespective of the current's magnitude and direction. The results also illustrate the effect of a cylinder's aspect ratio on force coefficients. This study will be useful in the design of offshore structures whose columns and caissons are rectangular sections

Efficient video transfer using LAN caching assisted by cloud computing

There is a good probability of accessing same video content multiple times from a cloud based Video Streaming Server by same peer or different peers of a given LAN, effectively increasing Internet bandwidth or data flow for same content from server to client, thereby over loading routers between server and client and also resulting in higher power consumption at routers. This proposed concept tries to avoid multiple streaming of high volume video files from Server by caching first successful streamed data on to LAN peer which is currently viewing the video data and subsequently the same LAN peer streaming the video to other desiring peers when demanded for. Proposed implementation model retains all other server activities with server except for allowing an available LAN peer copy of video to be streamed to another peer of the same LAN when requested for

Molecular cloning of growth hormone encoding cDNA of Indian major carps by a modified rapid amplification of cDNA ends strategy

A modified rapid amplification of cDNA ends (RACE) strategy has been developed for cloning highly conserved cDNA sequences. Using this modified method, the growth hormone (GH) encoding cDNA sequences of Labeo rohita, Cirrhina mrigala and Catla catla have been cloned, characterized and overexpressed in Escherichia coli. These sequences show 96-98% homology to each other and are about 85% homologous to that of common carp. Besides, an attempt has been made for the first time to describe a 3-D model of the fish GH protein

Calretinin expression in molecular subtypes of invasive carcinoma breast

Background: Breast cancer is a leading cause of cancer death  in women worldwide. Breast carcinoma is currently managed by assessing clinicopathological features. Elucidation of molecular mechanisms of pathogenesis of breast carcinoma  may lead to the development of new targeted therapies, particularly in triple negative cancers. Literature shows a few studies on the expression of calretinin  in breast carcinoma particularly in basal like type and its prognostic significance.  In this study, authors are trying  to assess the expression of  a new marker calretinin in different molecular subtypes of invasive carcinoma breast.Methods: This study was done in  107 cases of invasive carcinoma breast specimens received in  Department of Pathology, Government Medical college, Kottayam from December  2017 to May 2019.Results: Among the molecular subtypes, Basal like tumours showed 68.4% of cases with high level and 31.6% of cases with low level calretinin expression which is comparable with the study by Farrag et al. All the other molecular subgroups showed predominantly low level of calretinin expression.Conclusions: Different molecular subtypes of invasive carcinoma breast showed varied calretinin expression. High level calretinin expression was significantly associated with grade 3 (p value = 0.002), ER negativity (p = 0.004), PR negativity (p = 0.018)  and Basal like molecular subtype (p : <0.001). This suggests that calretinin might play a role in pathogenesis of basal like breast carcinomas

Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers

Electrospinning is an enabling technology that can architecturally (in terms of geometry, morphology or topography) and biochemically fabricate engineered cellular scaffolds that mimic the native extracellular matrix (ECM). This is especially important and forms one of the essential paradigms in the area of tissue engineering. While biomimesis of the physical dimensions of native ECM’s major constituents (eg, collagen) is no longer a fabrication-related challenge in tissue engineering research, conveying bioactivity to electrospun nanofibrous structures will determine the efficiency of utilizing electrospun nanofibers for regenerating biologically functional tissues. This can certainly be achieved through developing composite nanofibers. This article gives a brief overview on the current development and application status of employing electrospun composite nanofibers for constructing biomimetic and bioactive tissue scaffolds. Considering that composites consist of at least two material components and phases, this review details three different configurations of nanofibrous composite structures by using hybridizing basic binary material systems as example. These are components blended composite nanofiber, core-shell structured composite nanofiber, and nanofibrous mingled structure

Corrigendum to “Implementation of tidal turbines in MIKE 3 and Delft3D models of Pentland Firth & Orkney waters” [Ocean Coast. Manag. 147 (2017) 21–36]

© 2017 Elsevier Ltd The authors regret that a software error caused incorrect predictions for the effects of tidal turbines in Delft3D. The predictions without turbines are unaffected, as are those from the MIKE 3 model. The overall conclusions of the article remain valid. Figs. 12–15 as published are incorrect. Replacements for Figs. 12–14 are presented here. Following this correction the differences in the effects of energy extraction between the two models are much smaller. As a result the discussion of these differences in Section 6 should be disregarded, and Fig. 15 is no longer required. The authors would like to apologise for any inconvenience caused. The version of the code for adding turbines to Delft3D that is publicly available has been corrected, and anybody using this for their own work is urged to download the latest version. [Figure presented] Fig. 12: (a) 400 turbines in the Inner Sound, viewed through the MIKE Zero GUI; (b) The same 400 turbines represented as porous plates for Delft3D. Higher values of the closs parameter, shown by bluer colours, indicate plates with higher drag. [Figure presented] Fig. 13: Changes in mean current speeds over 28 days as a result of adding turbines. [Figure presented] Fig. 14: Change in mean bed stress magnitude over 28 days as a result of adding turbines, expressed as a proportion of the value without turbines

Cloning of partial putative gonadotropin hormone receptor sequence from fish

A search for the presence of mariner-like elements in the Labeo rohita genome by polymerase chain reaction led to the amplification of a partial DNA sequence coding for a putative transmembrane domain of gonadotropin hormone receptor. The amplified DNA sequence shows a high degree of homology to the available turkey and human luteinizing and follicle stimulating hormone receptor coding sequences. This is the first report on cloning such sequences of piscine origin

Cloud enabled 3D tablet design for medical applications

The prime objective of any technological innovation is to improve the life of people. Technological innovation in the field of medical devices directly touches the lives of millions of people; not just patients but doctors and other technicians as well. Serving these care givers is serving humanity. Growth of Mobil Devices and Cloud Computing has changed the way we live and work. We try to bring the benefits of these technological innovations to the medical field via equipment which can improve the working efficiencies and capabilities of the medical professionals and technicians. The improvements in the camera and image processing capabilities of the Mobile Devices coupled with their improved processing power and an infinite processing and storage offered by Cloud Computing infrastructure opens up a window of opportunity to use them in the specialized field like microsurgery. To enable microsurgery, surgeons use optical microscope to zoom into the working area to get better visibility and control. However, these devices suffer from various drawbacks and are not comfortable to use. We build a Tablet with large stereoscopic screen allowing glasses free 3D display enabled by cameras capable of capturing 3D video and enhanced by an image processing pipeline, greatly improves the visibility and viewing comfort of the surgeon. Moreover using the capabilities of Cloud computing, these surgeries can be recorded and streamed live for education, training and consultation. An expert sitting in a geographically remote location can guide the surgeon performing the surgery. All vital parameters of the patient undergoing surgery can be shown as an overlay on the Tablet screen so that the surgeon is alerted of any parameter going beyond limit. Developing this kind of complex device involves engineering skills in hardware and software and huge amount of investments in terms of time, resources and money. To accelerate the development, we make use of open source hardware and software and demonstrate how we can accelerate the development using these open source resources

Femtosecond to nanosecond excited states dynamics of novel Corroles

We report a comprehensive photphysical investigation of some corrole molecules employing fs/nanosecond (ns) transient-absorption and time-resolved photoluminescence spectroscopy with support from the time-dependent density-functional theory calculations to understand their intramolecular charge transfer and polaron-absorption character