Viral infections in interferon-gamma receptor deficiency.

Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens

Magnetization of nanoparticle systems in a rotating magnetic field

The investigation of a sizable thermal enhancement of magnetization is put forward for uniaxial ferromagnetic nanoparticles that are placed in a rotating magnetic field. We elucidate the nature of this phenomenon and evaluate the resonant frequency dependence of the induced magnetization. Moreover, we reveal the role of magnetic dipolar interactions, point out potential applications and reason the feasibility of an experimental observation of this effect.Comment: 10 pages, 2 figure

Establishing a children’s orthopaedic hospital for Malawi: A review after 10 years

BackgroundBEIT CURE International Hospital (BCIH) opened in 2002 providingorthopaedic surgical services to children in Malawi. This study reviews thehospital’s progress 10 years after establishment of operational services. Inaddition we assess the impact of the hospital’s Malawi national clubfootprogramme (MNCP) and influence on orthopaedic training.MethodsAll operative paediatric procedures performed by BCIH services in the10th operative year were included. Data on clubfoot clinic locations andnumber of patients treated were obtained from the MNCP. BCIH recordswere reviewed to identify the number of healthcare professionals whohave received training at the BCIH.Results609 new patients were operated on in the 10th year of hospital service.Patients were treated from all regions; however 60% came fromSouthern regions compared with the 48% in the 5th year. Clubfoot,burn contracture and angular lower limb deformities were the three mostcommon pathologies treated surgically. In total BCIH managed 9,842patients surgically over a 10-year period. BCIH helped to establish andco-ordinate the MNCP since 2007. At present the program has a totalof 29 clinics, which have treated 5748 patients. Furthermore, BCIH hasoverseen the full or partial training of 5 orthopaedic surgeons and 82orthopaedic clinical officers in Malawi.ConclusionThe BCIH has improved the care of paediatric patients in a country thatprior to its establishment had no dedicated paediatric orthopaedic service,treating almost 10,000 patients surgically and 6,000 patients in the MNCP.This service has remained consistent over a 10-year period despite times of global austerity. Whilst the type of training placement offered at BCIH has changed in the last 10 years, the priority placed on training has remained paramount. The strategic impact of long-term training  commitments are now being realised, in particular by the addition of Orthopaedic surgeons serving the nation

The effects of discreteness of galactic cosmic rays sources

Most studies of GeV Galactic Cosmic Rays (GCR) nuclei assume a steady state/continuous distribution for the sources of cosmic rays, but this distribution is actually discrete in time and in space. The current progress in our understanding of cosmic ray physics (acceleration, propagation), the required consistency in explaining several GCRs manifestation (nuclei, $\gamma$,...) as well as the precision of present and future space missions (e.g. INTEGRAL, AMS, AGILE, GLAST) point towards the necessity to go beyond this approximation. A steady state semi-analytical model that describes well many nuclei data has been developed in the past years based on this approximation, as well as others. We wish to extend it to a time dependent version, including discrete sources. As a first step, the validity of several approximations of the model we use are checked to validate the approach: i) the effect of the radial variation of the interstellar gas density is inspected and ii) the effect of a specific modeling for the galactic wind (linear vs constant) is discussed. In a second step, the approximation of using continuous sources in space is considered. This is completed by a study of time discreteness through the time-dependent version of the propagation equation. A new analytical solution of this equation for instantaneous point-like sources, including the effect of escape, galactic wind and spallation, is presented. Application of time and space discretness to definite propagation conditions and realistic distributions of sources will be presented in a future paper.Comment: final version, 8 figures, accepted in ApJ. A misprint in fig 8 labels has been correcte

Testing the proposed link between cosmic rays and cloud cover

A decrease in the globally averaged low level cloud cover, deduced from the ISCCP infra red data, as the cosmic ray intensity decreased during the solar cycle 22 was observed by two groups. The groups went on to hypothesise that the decrease in ionization due to cosmic rays causes the decrease in cloud cover, thereby explaining a large part of the presently observed global warming. We have examined this hypothesis to look for evidence to corroborate it. None has been found and so our conclusions are to doubt it. From the absence of corroborative evidence, we estimate that less than 23%, at the 95% confidence level, of the 11-year cycle change in the globally averaged cloud cover observed in solar cycle 22 is due to the change in the rate of ionization from the solar modulation of cosmic rays

The Modified Weighted Slab Technique: Models and Results

In an attempt to understand the source and propagation of galactic cosmic rays we have employed the Modified Weighted Slab technique along with recent values of the relevant cross sections to compute primary to secondary ratios including B/C and Sub-Fe/Fe for different galactic propagation models. The models that we have considered are the disk-halo diffusion model, the dynamical halo wind model, the turbulent diffusion model and a model with minimal reacceleration. The modified weighted slab technique will be briefly discussed and a more detailed description of the models will be given. We will also discuss the impact that the various models have on the problem of anisotropy at high energy and discuss what properties of a particular model bear on this issue.Comment: LaTeX - AASTEX format, Submitted to ApJ, 8 figures, 20 page

X-ray measured metallicities of the intra-cluster medium: a good measure for the metal mass?

Aims. We investigate whether X-ray observations map heavy elements in the Intra-Cluster Medium (ICM) well and whether the X-ray observations yield good estimates for the metal mass, with respect to predictions on transport mech- anisms of heavy elements from galaxies into the ICM. We further test the accuracy of simulated metallicity maps. Methods. We extract synthetic X-ray spectra from N-body/hydrodynamic simulations including metal enrichment pro- cesses, which we then analyse with the same methods as are applied to observations. By changing the metal distribution in the simulated galaxy clusters, we investigate the dependence of the overall metallicity as a function of the metal distribution. In addition we investigate the difference of X-ray weighted metal maps produced by simulations and metal maps extracted from artifcial X-ray spectra, which we calculate with SPEX2.0 and analyse with XSPEC12.0. Results. The overall metallicity depends strongly on the distribution of metals within the galaxy cluster. The more inhomogeneously the metals are distributed within the cluster, the less accurate is the metallicity as a measure for the true metal mass. The true metal mass is generally underestimated by X-ray observations. The difference between the X-ray weighted metal maps and the metal maps from synthetic X-ray spectra is on average less than 7% in the temperature regime above T > 3E7 K, i.e. X-ray weighted metal maps can be well used for comparison with observed metal maps. Extracting the metal mass in the central parts (r < 500 kpc) of galaxy clusters with X-ray observations results in metal mass underestimates up to a factor of three.Comment: 7 pages, 9 figures, accepted for publication in A&

Discovery of Extended Blue Horizontal Branches in Two Metal-Rich Globular Clusters

We have used WFPC2 to construct B, V color-magnitude diagrams of four metal-rich globular clusters, NGC 104 (47 Tuc), NGC 5927, NGC 6388, and NGC 6441. All four clusters have well populated red horizontal branches (RHB), as expected for their metallicity. However, NGC 6388 and 6441 also exhibit a prominent blue HB (BHB) extension, including stars reaching as faint in V as the turnoff luminosity. This discovery demonstrates directly for the first time that a major population of hot HB stars can exist in old, metal-rich systems. This may have important implications for the interpretation of the integrated spectra of elliptical galaxies. The cause of the phenomenon remains uncertain. We examine the possibility that NGC 6388 and 6441 are older than the other clusters, but a simple difference in age may not be sufficient to produce the observed distributions along the HB. The high central densities in NGC 6388 and 6441 suggest that the existence of the blue HB (BHB) tails might be caused by stellar interactions in the dense cores of these clusters, which we calculate to have two of the highest collision rates among globular clusters in the Galaxy. Tidal collisions might act in various ways to enhance loss of envelope mass, and therefore populate the blue side of the HB. However, the relative frequency of tidal collisions does not seem large enough (compared to that of the clusters with pure RHBs) to account for such a drastic difference in HB morphology. While a combination of an age difference and dynamical interactions may help, prima facie the lack of a radial gradient in the BHB/RHB star ratio seems to argue against dynamical effects playing a role.Comment: LaTeX, includes one Postscript figure. To appear in ApJ