A 4.8- and 8.6-GHz Survey of the Large Magellanic Cloud: I The Images

Detailed 4.8- and 8.6-GHz radio images of the entire Large Magellanic Cloud with half-power beamwidths of 33" at 4.8 GHz and 20" at 8.6 GHz have been obtained using the Australia Telescope Compact Array. A total of 7085 mosaic positions were used to cover an area of 6 degrees on a side. Full polarimetric observations were made. These images have sufficient spatial resolution (~8 and 5 pc, respectively) and sensitivity (3-sigma of 1 mJy/beam) to identify most of the individual SNRs and H II regions and also, in combination with available data from the Parkes 64-m telescope, the structure of the smooth emission in that galaxy. In addition, limited data using the sixth antenna at 4.5 to 6-km baselines are available to distinguish bright point sources (<3 and 2 arcsec, respectively) and to help estimate sizes of individual sources smaller than the resolution of the full survey. The resultant database will be valuable for statistical studies and comparisons with x-ray, optical and infrared surveys of the LMC with similar resolution.Comment: 28 pages, 10 figures, 2 tables, accepted for publication in the Feb 2005 A

TRIS III: the diffuse galactic radio emission at δ=+42∘\delta=+42^{\circ}

We present values of temperature and spectral index of the galactic diffuse radiation measured at 600 and 820 MHz along a 24 hours right ascension circle at declination $\delta = +42^{\circ}$. They have been obtained from a subset of absolute measurements of the sky temperature made with TRIS, an experiment devoted to the measurement of the Cosmic Microwave Background temperature at decimetric-wavelengths with an angular resolution of about $20^{\circ}$. Our analysis confirms the preexisting picture of the galactic diffuse emission at decimetric wavelength and improves the accuracy of the measurable quantities. In particular, the signal coming from the halo has a spectral index in the range $2.9-3.1$ above 600 MHz, depending on the sky position. In the disk, at TRIS angular resolution, the free-free emission accounts for the 11% of the overall signal at 600 MHz and 21% at 1420 MHz. The polarized component of the galactic emission, evaluated from the survey by Brouw and Spoelstra, affects the observations at TRIS angular resolution by less than 3% at 820 MHz and less than 2% at 600 MHz. Within the uncertainties, our determination of the galactic spectral index is practically unaffected by the correction for polarization. Since the overall error budget of the sky temperatures measured by TRIS at 600 MHz, that is 66 mK(systematic)$+$18 mK (statistical), is definitely smaller than those reported in previous measurements at the same frequency, our data have been used to discuss the zero levels of the sky maps at 150, 408, 820 and 1420 MHz in literature. Concerning the 408 MHz survey, limiting our attention to the patch of sky corresponding to the region observed by TRIS, we suggest a correction of the base-level of $(+3.9\pm 0.6)$K.Comment: Accepted for publication in the Astrophysical Journa

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly understood. Here we perform TCRB sequencing, integration site analysis, and single-cell RNA sequencing (scRNA-seq) to profile CD8+ CAR-T cells from infusion products (IPs) and blood of patients undergoing CD19 CAR-T immunotherapy. TCRB sequencing shows that clonal diversity of CAR-T cells is highest in the IPs and declines following infusion. We observe clones that display distinct patterns of clonal kinetics, making variable contributions to the CAR-T cell pool after infusion. Although integration site does not appear to be a key driver of clonal kinetics, scRNA-seq demonstrates that clones that expand after infusion mainly originate from infused clusters with higher expression of cytotoxicity and proliferation genes. Thus, we uncover transcriptional programs associated with CAR-T cell behavior after infusion.Published versio

TRIS II: search for CMB spectral distortions at 0.60, 0.82 and 2.5 GHz

With the TRIS experiment we have performed absolute measurements of the sky brightness in a sky circle at $\delta = +42^{\circ}$ at the frequencies $\nu =$ 0.60, 0.82 and 2.5 GHz. In this paper we discuss the techniques used to separate the different contributions to the sky emission and give an evaluation of the absolute temperature of the Cosmic Microwave Background. For the black-body temperature of the CMB we get: $T_{cmb}^{th}=(2.837 \pm 0.129 \pm 0.066)K$ at $\nu=0.60$ GHz; $T_{cmb}^{th}=(2.803 \pm 0.051 ^{+0.430} _{-0.300})K$ at $\nu=0.82$ GHz; $T_{cmb}^{th}=(2.516 \pm 0.139 \pm 0.284)K$ at $\nu=2.5$ GHz. The first error bar is statistic (1$\sigma$) while the second one is systematic. These results represent a significant improvement with respect to the previous measurements. We have also set new limits to the free-free distortions, $-6.3 \times 10^{-6} < Y_{ff} < 12.6 \times 10^{-6}$, and slightly improved the Bose-Einstein upper limit, $|\mu| < 6 \times 10^{-5}$, both at 95% confidence level.Comment: accepted for publication in The Astrophysical Journa

Fourier Modeling of the Radio Torus Surrounding Supernova 1987A

We present detailed Fourier modeling of the radio remnant of Supernova 1987A, using high-resolution 9 GHz and 18 GHz data taken with the Australia Telescope Compact Array over the period 1992 to 2008. We develop a parameterized three-dimensional torus model for the expanding radio shell, in which the emission is confined to an inclined equatorial belt; our model also incorporates both a correction for light travel-time effects and an overall east-west gradient in the radio emissivity. By deriving an analytic expression for the two-dimensional Fourier transform of the projected three-dimensional brightness distribution, we can fit our spatial model directly to the interferometric visibility data. This provides robust estimates to the radio morphology at each epoch. The best-fit results suggest a constant remnant expansion at 4000 +/- 400 km/s over the 16-year period covered by the observations. The model fits also indicate substantial mid-latitude emission, extending to 40 degree on either side of the equatorial plane. This likely corresponds to the extra-planar structure seen in H$\alpha$ and Ly$\alpha$ emission from the supernova reverse shock, and broadly supports hydrodynamic models in which the complex circumstellar environment was produced by a progression of interacting winds from the progenitor. Our model quantifies the clear asymmetry seen in the radio images: we find that the eastern half of the radio remnant is consistently ~40 brighter than the western half at all epochs, which may result from an asymmetry in the ejecta distribution between these two hemispheres.Comment: accepted by ApJ, 11 figures, some have been scaled down in resolutio

Cardiac-sparing radiotherapy for locally advanced non-small cell lung cancer

Background We have carried out a study to determine the scope for reducing heart doses in photon beam radiotherapy of locally advanced non-small cell lung cancer (LA-NSCLC). Materials and methods Baseline VMAT plans were created for 20 LA-NSCLC patients following the IDEAL-CRT isotoxic protocol, and were re-optimized after adding an objective limiting heart mean dose (MDHeart). Reductions in MDHeart achievable without breaching limits on target coverage or normal tissue irradiation were determined. The process was repeated for objectives limiting the heart volume receiving ≥ 50 Gy (VHeart-50-Gy) and left atrial wall volume receiving ≥ 63 Gy (VLAwall-63-Gy). Results Following re-optimization, mean MDHeart, VHeart-50-Gy and VLAwall-63-Gy values fell by 4.8 Gy and 2.2% and 2.4% absolute respectively. On the basis of associations observed between survival and cardiac irradiation in an independent dataset, the purposefully-achieved reduction in MDHeart is expected to lead to the largest improvement in overall survival. It also led to useful knock-on reductions in many measures of cardiac irradiation including VHeart-50-Gy and VLAwall-63-Gy, providing some insurance against survival being more strongly related to these measures than to MDHeart. The predicted hazard ratio (HR) for death corresponding to the purposefully-achieved mean reduction in MDHeart was 0.806, according to which a randomized trial would require 1140 patients to test improved survival with 0.05 significance and 80% power. In patients whose baseline MDHeart values exceeded the median value in a published series, the average MDHeart reduction was particularly large, 8.8 Gy. The corresponding predicted HR is potentially testable in trials recruiting 359 patients enriched for greater MDHeart values. Conclusions Cardiac irradiation in RT of LA-NSCLC can be reduced substantially. Of the measures studied, reduction of MDHeart led to the greatest predicted increase in survival, and to useful knock-on reductions in other cardiac irradiation measures reported to be associated with survival. Potential improvements in survival can be trialled more efficiently in a population enriched for patients with greater baseline MDHeart levels, for whom larger reductions in heart doses can be achieved

A high-resolution radio survey of the Vela supernova remnant

This paper presents a high-resolution radio continuum (843 MHz) survey of the Vela supernova remnant. The contrast between the structures in the central pulsar-powered nebula of the remnant and the synchrotron radiation shell allows the remnant to be identified morphologically as a member of the composite class. The data are the first of a composite remnant at spatial scales comparable with those available for the Cygnus Loop and the Crab Nebula, and make possible a comparison of radio, optical and soft X-ray emission from the resolved shell filaments. The survey, made with the Molonglo Observatory Synthesis Telescope, covers an area of 50 square degrees at a resolution of 43'' x 60'', while imaging structures on scales up to 30'.Comment: 18 pages, 7 jpg figures (version with ps figures at http://astro.berkeley.edu/~dbock/papers/); AJ, in pres

A Sino-German λ\lambda6\ cm polarization survey of the Galactic plane VI. Discovery of supernova remnants G178.2-4.2 and G25.1-2.3

Supernova remnants (SNRs) were often discovered in radio surveys of the Galactic plane. Because of the surface-brightness limit of previous surveys, more faint or confused SNRs await discovery. The Sino-German $\lambda$6\ cm Galactic plane survey is a sensitive survey with the potential to detect new low surface-brightness SNRs. We want to identify new SNRs from the $\lambda$6\ cm survey map of the Galactic plane. We searched for new shell-like objects in the $\lambda$6\ cm survey maps, and studied their radio emission, polarization, and spectra using the $\lambda$6\ cm maps together with the $\lambda$11\ cm and $\lambda$21\ cm Effelsberg observations. Extended polarized objects with non-thermal spectra were identified as SNRs. We have discovered two new, large, faint SNRs, G178.2-4.2 and G25.1-2.3, both of which show shell structure. G178.2-4.2 has a size of 72 arcmin x 62 arcmin with strongly polarized emission being detected along its northern shell. The spectrum of G178.2-4.2 is non-thermal, with an integrated spectral index of $\alpha = -0.48\pm0.13$. Its surface brightness is $\Sigma_{1 GHz} = 7.2 x 10^{-23}{Wm^{-2} Hz^{-1} sr^{-1}}$, which makes G178.2-4.2 the second faintest known Galactic SNR. G25.1-2.3 is revealed by its strong southern shell which has a size of 80 arcmin x 30\arcmin. It has a non-thermal radio spectrum with a spectral index of $\alpha = -0.49\pm0.13$. Two new large shell-type SNRs have been detected at $\lambda$6\ cm in an area of 2200 deg^2 along the the Galactic plane. This demonstrates that more large and faint SNRs exist, but are very difficult to detect.Comment: 8 pages, 8 figures, accepted by Astronomy and Astrophysics. For the version with high resolution figures, please go to http://zmtt.bao.ac.cn/6cm/papers/2newSNR.pd

Tidal Heating: Lessons from Io and the Jovian System (Report from the KISS Workshop)

Summary of the Keck Institute for Space Studies workshop entitled "Tidal Heating: Lessons from Io and the Jovian System," held on October 15-19, 2018