FORMULATION AND EVALUATION OF ACARBOSE PELLETS BY EXTRUSION SPHERONIZATION TECHNIQUE

Objective: The objective of our work is to formulate and evaluate acarbose pellets for sustain drug delivery. The present study was aimed to develop sustain drug delivery system of acarbose pellets by extrusion spheronization technique using different polymers like Hydroxypropyl methyl cellulose, chitosan, ethylcellulose, microcrystalline cellulose. Pelletization of acarbose was done to achieve sustain drug release profile suitable for oral administration. Methods: The acarbose pellets were prepared by extrusion spheronization technique. The Fourier transform-infrared spectrum (FT-IR) and Differential scanning calorimetry thermogram of pure drug and drug-polymer blend showed the stable character of acarbose in the pellets. The prepared pellets were evaluated for different quality control parameters like particle size analysis, drug content, and Drug release characteristics. Results: The results obtained from different quality control parameters are within acceptable range and In vitro dissolution studies indicated that drug release from pellets follows zero-order kinetics with sustain release drug release up to 12 h with the use of ethyl cellulose as a sustain release polymer and mechanism of drug release is non-fickian. The formulated pellets were stable with respect to their physicochemical characters and drug content over a period of 60 d at accelerated stability condition. Conclusion: From present study, it was concluded that formulation of acarbose pellets by this will be a promising technique for the preparation of pellets to sustain drug release for the treatment of diabetes with better patient compliance

Finding the Center of Mass of a Soft Spring

This article shows how to use calculus to find the center of mass position of a soft cylindrical helical spring that is suspended vertically. The spring is non-uniformly stretched by the action of gravity. A general expression for the vertical position of the center of mass is obtained.Comment: LaTeX, 7 pages, 2 figures. Minor changes to agree with published versio

A report on the nonlinear squeezed states and their non-classical properties of a generalized isotonic oscillator

We construct nonlinear squeezed states of a generalized isotonic oscillator potential. We demonstrate the non-existence of dual counterpart of nonlinear squeezed states in this system. We investigate statistical properties exhibited by the squeezed states, in particular Mandel's parameter, second-order correlation function, photon number distributions and parameter $A_3$ in detail. We also examine the quadrature and amplitude-squared squeezing effects. Finally, we derive expression for the $s$-parameterized quasi-probability distribution function of these states. All these information about the system are new to the literature.Comment: Accepted for publication in J. Phys. A: Math. Theo

Political Identity Biases Americans’ Judgments of Outgroup Emotion

Social group identity plays a central role in political polarization and inter-party conflict. Here, we use ambiguously valenced faces to measure bias in the processing of political ingroup and outgroup faces, while also accounting for interparty differences in judgments of emotion at baseline. Participants identifying as Democrats and Republicans judged happy, angry, and surprised faces as positive or negative. Whereas happy and angry faces convey positive and negative valence respectively, surprised faces are ambiguous in that they readily convey positive and negative valence. Thus, surprise is a useful tool for characterizing valence bias (i.e., the tendency to judge ambiguous stimuli as negative). Face stimuli were assigned to the participants’ political ingroup or outgroup, or a third group with an unspecified affiliation (baseline). We found a significant interaction of facial expression and group membership, such that outgroup faces were judged more negatively than ingroup and baseline, but only for surprise. There was also an interaction of facial expression and political affiliation, with Republicans judging surprise more negatively than Democrats across all group conditions. However, we did not find evidence for party differences in outgroup negativity. Our findings demonstrate the utility of judgments of surprised faces as a measure of intergroup bias, and reinforce the importance of outgroup negativity (relative to ingroup positivity) for explaining inter-party biases

An orbital perspective on the starvation, stripping, and quenching of satellite galaxies in the EAGLE simulations

Using the EAGLE suite of simulations, we demonstrate that both cold gas stripping {\it and} starvation of gas inflow play an important role in quenching satellite galaxies across a range of stellar and halo masses, $M_{\star}$ and $M_{200}$. By quantifying the balance between gas inflows, outflows, and star formation rates, we show that even at $z=2$, only $\approx30\%$ of satellite galaxies are able to maintain equilibrium or grow their reservoir of cool gas - compared to $\approx50\%$ of central galaxies at this redshift. We find that the number of orbits completed by a satellite is a very good predictor of its quenching, even more so than the time since infall. On average, we show that intermediate-mass satellites with $M_{\star}$ between $10^{9}{\rm M}_{\odot}-10^{10}{\rm M}_{\odot}$ will be quenched at first pericenter in massive group environments, $M_{200}>10^{13.5}{\rm M}_{\odot}$; and will be quenched at second pericenter in less massive group environments, $M_{200}<10^{13.5}{\rm M}_{\odot}$. On average, more massive satellites ($M_{\star}>10^{10}{\rm M}_{\odot}$) experience longer depletion time-scales, being quenched between first and second pericenters in massive groups; while in smaller group environments, just $\approx30\%$ will be quenched even after two orbits. Our results suggest that while starvation alone may be enough to slowly quench satellite galaxies, direct gas stripping, particularly at pericenters, is required to produce the short quenching time-scales exhibited in the simulation.Comment: Accepted for publication in MNRA

STRATEGIC AGRIBUSINESS OPERATION REALIGNMENT IN THE TEXAS PRISON SYSTEM

Mathematical programming-based systems analysis is used to examine the consequences of alternative operation configuration for the agricultural operations within the Texas Department of Criminal Justice. Continuation versus elimination of the total operation as well as individual operating departments are considered. Methodology includes a firm systems operation model combined with capital budgeting and an integer programming based investment model. Results indicate the resources realize a positive return as a whole, but some enterprises are not using resources profitably. The integer investment model is found to be superior for investigating whether to continue multiple interrelated enterprises.agribusiness, enterprise selection, mathematical programming, optimal enterprise organization, Agribusiness,

Comparative Analysis of Tandem Repeats from Hundreds of Species Reveals Unique Insights into Centromere Evolution

Centromeres are essential for chromosome segregation, yet their DNA sequences evolve rapidly. In most animals and plants that have been studied, centromeres contain megabase-scale arrays of tandem repeats. Despite their importance, very little is known about the degree to which centromere tandem repeats share common properties between different species across different phyla. We used bioinformatic methods to identify high-copy tandem repeats from 282 species using publicly available genomic sequence and our own data. The assumption that the most abundant tandem repeat is the centromere DNA was true for most species whose centromeres have been previously characterized, suggesting this is a general property of genomes. Our methods are compatible with all current sequencing technologies. Long Pacific Biosciences sequence reads allowed us to find tandem repeat monomers up to 1,419 bp. High-copy centromere tandem repeats were found in almost all animal and plant genomes, but repeat monomers were highly variable in sequence composition and in length. Furthermore, phylogenetic analysis of sequence homology showed little evidence of sequence conservation beyond ~50 million years of divergence. We find that despite an overall lack of sequence conservation, centromere tandem repeats from diverse species showed similar modes of evolution, including the appearance of higher order repeat structures in which several polymorphic monomers make up a larger repeating unit. While centromere position in most eukaryotes is epigenetically determined, our results indicate that tandem repeats are highly prevalent at centromeres of both animals and plants. This suggests a functional role for such repeats, perhaps in promoting concerted evolution of centromere DNA across chromosomes