Context-based generation of kinetic equations with SBMLsqueezer 1.3

The development of predictive, quantitative models constitutes a common task in today‘s systems biology. To obtain a mathematical model description for the simulation of gene-regulatory, signaling, and metabolic networks, kinetic equations are required for each reaction within the network. Deriving and assembling these formulas is a complicated, time-consuming, and error-prone process that requires knowledge about the structure of interactions, consistently choosing a rate law for each type of reaction, and assignment of appropriate units to all parameters. In many cases, thermodynamic dependencies between the parameters have to be taken into account. For multi compartment models, the concentration units of reacting species have to be converted into molecular amounts. Here we present version 1.3 of the program SBMLsqueezer that generates kinetic equations for SBML models based on the definition of the network's topology and annotations of the elements therein, i.e., Systems Biology Ontology (SBO) and Minimal Information Requested In the Annotation of Models (MIRIAM) annotations

The Grizzly, February 6, 1987

Residential Village Saluted: Ursinus Recipient of County Planning Award • Art Critic Kuspit Condemns Ursinus\u27 Acquisitions • Biology Dept. Offers Field Study • Letters: Pro Abortion Bias Suggested; Art Critic Elitist; Hoopsters Accomplish Goals Despite Poor Press; Kane Commends McCullough • News Notes: Weaver to Play on Heefner Organ Again; Board Member Jeffers Dies at 79; Health Promotion Project; Lorelei, a U.C. Tradition • The Coddling of College Students • Connolly Finds Berry Piece Arrogant, Rash and True • Grappling Bears Stun Opponents in Streaking to 9-2 • Ursinus Roars Back to Thrash Hopkins • Men\u27s Track Impressive Early in Season • Mer Men Waiting for Loyola • Lady Hoopsters Capture First Home Win • Sophomore Wrestler Seislove on a Roll • A Baby and the Ball - Two Plays Called at Once • Japanese Program Offered Again • Fishing Club Factshttps://digitalcommons.ursinus.edu/grizzlynews/1180/thumbnail.jp

Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations

Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class antibodies, are increasingly used to treat a broad range of pathological conditions, including humoral immune deficiencies, as well as acute and chronic inflammatory or autoimmune disorders. A plethora of Fab- or Fc-mediated immune regulatory mechanisms has been described that might act separately or in concert, depending on pathogenesis or stage of clinical condition. Attempts have been undertaken to improve the efficacy of polyclonal IgG preparations, including the identification of relevant subfractions, mild chemical modification of molecules, or modification of carbohydrate side chains. Furthermore, plasma-derived IgA or IgM preparations may exhibit characteristics that might be exploited therapeutically. The need for improved treatment strategies without increase in plasma demand is a goal and might be achieved by more optimal use of plasma-derived proteins, including the IgA and the IgM fractions. This article provides an overview on the current knowledge and future strategies to improve the efficacy of regular IgG preparations and discusses the potential of human plasma-derived IgA, IgM, and preparations composed of mixtures of IgG, IgA, and IgM