15,301 research outputs found
Motor Recovery After Subcortical Stroke Depends on Modulation of Extant Motor Networks
Introduction: Stroke is the leading cause of long-term disability. Functional imaging studies report widespread changes in movement-related cortical networks after stroke. Whether these are a result of stroke-specific cognitive processes or reflect modulation of existing movement-related networks is unknown. Understanding this distinction is critical in establishing more effective restorative therapies after stroke. Using multivariate analysis (tensor-independent component analysis – TICA), we map the neural networks involved during motor imagery (MI) and executed movement (EM) in subcortical stroke patients and age-matched controls.
Methods: Twenty subcortical stroke patients and 17 age-matched controls were recruited. They were screened for their ability to carry out MI (Chaotic MI Assessment). The fMRI task was a right-hand finger-thumb opposition sequence (auditory-paced 1 Hz; 2, 3, 4, 5, 2…). Two separate runs were acquired (MI and rest and EM and rest; block design). There was no distinction between groups or tasks until the last stage of analysis, which allowed TICA to identify independent components (ICs) that were common or distinct to each group or task with no prior assumptions.
Results: TICA defined 28 ICs. ICs representing artifacts were excluded. ICs were only included if the subject scores were significant (for either EM or MI). Seven ICs remained that involved the primary and secondary motor networks. All ICs were shared between the stroke and age-matched controls. Five ICs were common to both tasks and three were exclusive to EM. Two ICs were related to motor recovery and one with time since stroke onset, but all were shared with age-matched controls. No IC was exclusive to stroke patients.
Conclusion: We report that the cortical networks in stroke patients that relate to recovery of motor function represent modulation of existing cortical networks present in age-matched controls. The absence of cortical networks specific to stroke patients suggests that motor adaptation and other potential confounders (e.g., effort and additional muscle use) are not responsible for the changes in the cortical networks reported after stroke. This highlights that recovery of motor function after subcortical stroke involves preexisting cortical networks that could help identify more effective restorative therapies
Beyond Worst-Case Analysis for Joins with Minesweeper
We describe a new algorithm, Minesweeper, that is able to satisfy stronger
runtime guarantees than previous join algorithms (colloquially, `beyond
worst-case guarantees') for data in indexed search trees. Our first
contribution is developing a framework to measure this stronger notion of
complexity, which we call {\it certificate complexity}, that extends notions of
Barbay et al. and Demaine et al.; a certificate is a set of propositional
formulae that certifies that the output is correct. This notion captures a
natural class of join algorithms. In addition, the certificate allows us to
define a strictly stronger notion of runtime complexity than traditional
worst-case guarantees. Our second contribution is to develop a dichotomy
theorem for the certificate-based notion of complexity. Roughly, we show that
Minesweeper evaluates -acyclic queries in time linear in the certificate
plus the output size, while for any -cyclic query there is some instance
that takes superlinear time in the certificate (and for which the output is no
larger than the certificate size). We also extend our certificate-complexity
analysis to queries with bounded treewidth and the triangle query.Comment: [This is the full version of our PODS'2014 paper.
PAR7: ASSESSMENT OF THE BURDEN OF RHEUMATOID ARTHRITIS IN FRENCH HOSPITALS:ANALYSIS OF THE PMSI DATABASE
High frequency dynamics in a monatomic glass
The high frequency dynamics of glassy Selenium has been studied by Inelastic
X-ray Scattering at beamline BL35XU (SPring-8). The high quality of the data
allows one to pinpoint the existence of a dispersing acoustic mode for
wavevectors () of nm, helping to clarify a previous
contradiction between experimental and numerical results. The sound velocity
shows a positive dispersion, exceeding the hydrodynamic value by 10%
at nm. The dependence of the sound attenuation
, reported for other glasses, is found to be the low- limit of a
more general law which applies also to the
higher region, where no longer holds.Comment: Phys. Rev. Lett. (Accepted
Stellar Population Models and Individual Element Abundances I: Sensitivity of Stellar Evolution Models
Integrated light from distant galaxies is often compared to stellar
population models via the equivalent widths of spectral features--spectral
indices--whose strengths rely on the abundances of one or more elements. Such
comparisons hinge not only on the overall metal abundance but also on relative
abundances. Studies have examined the influence of individual elements on
synthetic spectra but little has been done to address similar issues in the
stellar evolution models that underlie most stellar population models. Stellar
evolution models will primarily be influenced by changes in opacities. In order
to explore this issue in detail, twelve sets of stellar evolution tracks and
isochrones have been created at constant heavy element mass fraction Z that
self-consistently account for varying heavy element mixtures. These sets
include scaled-solar, alpha-enhanced, and individual cases where the elements
C, N, O, Ne, Mg, Si, S, Ca, Ti, and Fe have been enhanced above their
scaled-solar values. The variations that arise between scaled-solar and the
other cases are examined with respect to the H-R diagram and main sequence
lifetimes.Comment: 33 pages, 13 figures, accepted to Ap
Analytic Inversion of Emission Lines of Arbitrary Optical Depth for the Structure of Supernova Ejecta
We derive a method for inverting emission line profiles formed in supernova
ejecta. The derivation assumes spherical symmetry and homologous expansion
(i.e., ), is analytic, and even takes account of occultation by
a pseudo-photosphere. Previous inversion methods have been developed which are
restricted to optically thin lines, but the particular case of homologous
expansion permits an analytic result for lines of {\it arbitrary} optical
depth. In fact, we show that the quantity that is generically retrieved is the
run of line intensity with radius in the ejecta. This result is
quite general, and so could be applied to resonance lines, recombination lines,
etc. As a specific example, we show how to derive the run of (Sobolev) optical
depth with radius in the case of a pure resonance scattering
emission line.Comment: 6 pages, no figures, to appear in Astrophysical Journal Letters,
requires aaspp4.sty to late
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