Accuracy of leukocyte alkaline phosphatase score to predict JAK2 V617F mutation

Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients’ peripheral blood with MPD

Spatial and temporal distribution of Mycobacterium tuberculosis complex infection in Eurasian badger (Meles meles) and cattle in Asturias, Spain

Trabajo presentado al: 69th Wildlife Disease Association and 14th European Wildlife Disease Association Conference. Cuenca, Spain. p. 66. 31 agosto-2 septiembre

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination

The presence of hypoxic regions in solid tumors is an adverse prognostic factor for patient outcome. Here, we show that hypoxia induces the expression of Ephrin-A3 through a novel hypoxia-inducible factor (HIF)-mediated mechanism. In response to hypoxia, the coding EFNA3 mRNA levels remained relatively stable, but HIFs drove the expression of previously unknown long noncoding (lnc) RNAs from EFNA3 locus and these lncRNA caused Ephrin-A3 protein accumulation. Ephrins are cell surface proteins that regulate diverse biological processes by modulating cellular adhesion and repulsion. Mounting evidence implicates deregulated ephrin function in multiple aspects of tumor biology. We demonstrate that sustained expression of both Ephrin-A3 and novel EFNA3 lncRNAs increased the metastatic potential of human breast cancer cells, possibly by increasing the ability of tumor cells to extravasate from the blood vessels into surrounding tissue. In agreement, we found a strong correlation between high EFNA3 expression and shorter metastasis-free survival in breast cancer patients. Taken together, our results suggest that hypoxia could contribute to metastatic spread of breast cancer via HIF-mediated induction of EFNA3 lncRNAs and subsequent Ephrin-A3 protein accumulation

The Blazar TXS 0506+056 Associated with a High-energy Neutrino: Insights into Extragalactic Jets and Cosmic-Ray Acceleration

A neutrino with energy ∼290 TeV, IceCube-170922A, was detected in coincidence with the BL Lac object TXS 0506+056 during enhanced gamma-ray activity, with chance coincidence being rejected at ∼3σ level. We monitored the object in the very-high-energy (VHE) band with the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes for ∼41 hr from 1.3 to 40.4 days after the neutrino detection. Day-timescale variability is clearly resolved. We interpret the quasi-simultaneous neutrino and broadband electromagnetic observations with a novel one-zone lepto-hadronic model, based on interactions of electrons and protons co-accelerated in the jet with external photons originating from a slow-moving plasma sheath surrounding the faster jet spine. We can reproduce the multiwavelength spectra of TXS 0506+056 with neutrino rate and energy compatible with IceCube-170922A, and with plausible values for the jet power of . The steep spectrum observed by MAGIC is concordant with internal γγ absorption above ∼100 GeV entailed by photohadronic production of a ∼290 TeV neutrino, corroborating a genuine connection between the multi-messenger signals. In contrast to previous predictions of predominantly hadronic emission from neutrino sources, the gamma-rays can be mostly ascribed to inverse Compton upscattering of external photons by accelerated electrons. The X-ray and VHE bands provide crucial constraints on the emission from both accelerated electrons and protons. We infer that the maximum energy of protons in the jet comoving frame can be in the range ∼1014 – 1018 eV.Peer Reviewe

Statistics of VHE γ -rays in temporal association with radio giant pulses from the Crab pulsar

Aims. The aim of this study is to search for evidence of a common emission engine between radio giant pulses (GPs) and very-high-energy (VHE, E  >   100 GeV) γ-rays from the Crab pulsar. Methods. We performed 16 h of simultaneous observations of the Crab pulsar at 1.4 GHz with the Effelsberg radio telescope and the Westerbork Synthesis Radio Telescope (WSRT), and at energies above 60 GeV we used the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes. We searched for a statistical correlation between the radio and VHE γ-ray emission with search windows of different lengths and different time lags to the arrival times of a radio GP. A dedicated search for an enhancement in the number of VHE γ-rays correlated with the occurrence of radio GPs was carried out separately for the P1 and P2 phase ranges, respectively. Results. In the radio data sample, 99444 radio GPs were detected. We find no significant correlation between the GPs and VHE photons in any of the search windows. Depending on phase cuts and the chosen search windows, we find upper limits at a 95% confidence level on an increase in VHE γ-ray events correlated with radio GPs between 7% and 61% of the average Crab pulsar VHE flux for the P1 and P2 phase ranges, respectively. This puts upper limits on the flux increase during a radio GP between 12% and 2900% of the pulsed VHE flux, depending on the search window duration and phase cuts. This is the most stringent upper limit on a correlation between γ-ray emission and radio GPs reported so far

Statistics of VHE \u3b3-rays in temporal association with radio giant pulses from the Crab pulsar

Aims. The aim of this study is to search for evidence of a common emission engine between radio giant pulses (GPs) and very-high-energy (VHE, E& x2004;> & x2004;100 GeV) gamma-rays from the Crab pulsar. Methods. We performed 16 h of simultaneous observations of the Crab pulsar at 1.4 GHz with the Effelsberg radio telescope and the Westerbork Synthesis Radio Telescope (WSRT), and at energies above 60 GeV we used the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes. We searched for a statistical correlation between the radio and VHE gamma-ray emission with search windows of different lengths and different time lags to the arrival times of a radio GP. A dedicated search for an enhancement in the number of VHE gamma-rays correlated with the occurrence of radio GPs was carried out separately for the P1 and P2 phase ranges, respectively. Results. In the radio data sample, 99444 radio GPs were detected. We find no significant correlation between the GPs and VHE photons in any of the search windows. Depending on phase cuts and the chosen search windows, we find upper limits at a 95% confidence level on an increase in VHE gamma-ray events correlated with radio GPs between 7% and 61% of the average Crab pulsar VHE flux for the P1 and P2 phase ranges, respectively. This puts upper limits on the flux increase during a radio GP between 12% and 2900% of the pulsed VHE flux, depending on the search window duration and phase cuts. This is the most stringent upper limit on a correlation between gamma-ray emission and radio GPs reported so far

Discovery of TeV γ-ray emission from the neighbourhood of the supernova remnant G24.7+0.6 by MAGIC

SNR G24.7+0.6 is a 9.5 kyrs radio and gamma-ray supernova remnant evolving in a dense medium. In the GeV regime, SNR G24.7+0.6 (3FHL J1834.1– 0706e/FGES J1834.1–0706) shows a hard spectral index (Γ∼2) up to 200 GeV, which makes it a good candidate to be observed with Cherenkov telescopes such as MAGIC. We observed the field of view of SNR G24.7+0.6 with the MAGIC telescopes for a total of 31 hours. We detect very high energy γ-ray emission from an extended source located 0.34 degree away from the center of the radio SNR. The new source, named MAGIC J1835–069 is detected up to 5 TeV, and its spectrum is well-represented by a power-law function with spectral index of 2.74 ± 0.08. The complexity of the region makes the identification of the origin of the very-high energy emission difficult, however the spectral agreement with the LAT source and overlapping position at less than 1.5 sigma point to a common origin. We analysed 8 years of Fermi-LAT data to extend the spectrum of the source down to 60 MeV. Fermi-LAT and MAGIC spectra overlap within errors and the global broad band spectrum is described by a power-law with exponential cutoff at 1.9 ± 0.5 TeV. The detected γ-ray emission can be interpreted as the results of proton-proton interaction between the supernova and the CO-rich surrounding

A fast, very-high-energy γ -ray flare from BL Lacertae during a period of multi-wavelength activity in June 2015

The mechanisms producing fast variability of the γ-ray emission in active galactic nuclei (AGNs) are under debate. The MAGIC telescopes detected a fast, very-high-energy (VHE, E > 100 GeV) γ-ray flare from BL Lacertae on 2015 June 15. The flare had a maximum flux of (1.5 ± 0.3) × 10-10 photons cm-2 s-1 and halving time of 26 ± 8 min. The MAGIC observations were triggered by a high state in the optical and high-energy (HE, E > 100 MeV) γ-ray bands. In this paper we present the MAGIC VHE γ-ray data together with multi-wavelength data from radio, optical, X-rays, and HE γ rays from 2015 May 1 to July 31. Well-sampled multi-wavelength data allow us to study the variability in detail and compare it to the other epochs when fast, VHE γ-ray flares have been detected from this source. Interestingly, we find that the behaviour in radio, optical, X-rays, and HE γ-rays is very similar to two other observed VHE γ-ray flares. In particular, also during this flare there was an indication of rotation of the optical polarization angle and of activity at the 43 GHz core. These repeating patterns indicate a connection between the three events. We also test modelling of the spectral energy distribution based on constraints from the light curves and VLBA observations, with two different geometrical setups of two-zone inverse Compton models. In addition we model the γ-ray data with the star-jet interaction model. We find that all of the tested emission models are compatible with the fast VHE γ-ray flare, but all have some tension with the multi-wavelength observations

Measurement of the Extragalactic Background Light using MAGIC and Fermi-LAT gamma-ray observations of blazars up to z = 1

We present a measurement of the extragalactic background light (EBL) based on a joint likelihood analysis of 32 gamma-ray spectra for 12 blazars in the redshift range z = 0.03 to 0.944, obtained by the MAGIC telescopes and Fermi-LAT. The EBL is the part of the diffuse extragalactic radiation spanning the ultraviolet, visible and infrared bands. Major contributors to the EBL are the light emitted by stars through the history of the universe, and the fraction of it which was absorbed by dust in galaxies and re-emitted at longer wavelengths. The EBL can be studied indirectly through its effect on very-high energy photons that are emitted by cosmic sources and absorbed via photon-photon interactions during their propagation across cosmological distances. We obtain estimates of the EBL density in good agreement with state-of-the-art models of the EBL production and evolution. The 1-sigma upper bounds, including systematic uncertainties, are between 13% and 23% above the nominal EBL density in the models. No anomaly in the expected transparency of the universe to gamma rays is observed in any range of optical depth.We also perform a wavelength-resolved EBL determination, which results in a hint of an excess of EBL in the 0.18 - 0.62 $\mu$m range relative to the studied models, yet compatible with them within systematics.Comment: Accepted by MNRA

Detection of persistent VHE gamma-ray emission from PKS 1510-089 by the MAGIC telescopes during low states between 2012 and 2017

PKS 1510-089 is a flat spectrum radio quasar strongly variable in the optical and GeV range. To date, very high-energy (VHE, > 100 GeV) emission has been observed from this source either during long high states of optical and GeV activity or during short flares. Aims. We search for low-state VHE gamma-ray emission from PKS 1510-089. We characterize and model the source in a broadband context, which would provide a baseline over which high states and flares could be better understood. Methods. PKS 1510-089 has been monitored by the MAGIC telescopes since 2012. We use daily binned Fermi-LAT flux measurements of PKS 1510-089 to characterize the GeV emission and select the observation periods of MAGIC during low state of activity. For the selected times we compute the average radio, IR, optical, UV, X-ray, and gamma-ray emission to construct a low-state spectral energy distribution of the source. The broadband emission is modeled within an external Compton scenario with a stationary emission region through which plasma and magnetic fields are flowing. We also perform the emission-model-independent calculations of the maximum absorption in the broad line region (BLR) using two different models. Results. The MAGIC telescopes collected 75 hr of data during times when the Fermi-LAT flux measured above 1 GeV was below 3? × 10 -8 ? cm -2 ? s -1 , which is the threshold adopted for the definition of a low gamma-ray activity state. The data show a strongly significant (9.5¿) VHE gamma-ray emission at the level of (4.27 ± 0.61 stat ) × 10 -12 ? cm -2 ? s -1 above 150 GeV, a factor of 80 lower than the highest flare observed so far from this object. Despite the lower flux, the spectral shape is consistent with earlier detections in the VHE band. The broadband emission is compatible with the external Compton scenario assuming a large emission region located beyond the BLR. For the first time the gamma-ray data allow us to place a limit on the location of the emission region during a low gamma-ray state of a FSRQ. For the used model of the BLR, the 95% confidence level on the location of the emission region allows us to place it at a distance > 74% of the outer radius of the BLR. © ESO 2018.The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, CSD2009-00064), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Exce-lencia “Severo Ochoa” SEV-2012-0234 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq and FAPERJ. IA acknowledges support from a Ramón y Cajal grant of the Ministerio de Economía, Industria, y Competitividad (MINECO) of Spain. Acquisition and reduction of the POLAMI and MAPCAT data was supported in part by MINECO through grants AYA2010-14844, AYA2013-40825-P, and AYA2016-80889-P, and by the Regional Government of Andalucía through grant P09-FQM-4784.Peer Reviewe