Glaciolacustrine deposits formed in an ice-dammed tributary valley in the south-central Pyrenees: new evidence for late Pleistocene climate

Combined geomorphic features, stratigraphic characteristics and sedimentologic interpretation, coupled with optically stimulated luminescence (OSL) dates, of a glacio-fluvio-lacustrine sequence (Linás de Broto, northern Spain) provide new information to understand the palaeoenvironmental significance of dynamics of glacier systems in the south-central Pyrenees during the Last Glacial Cycle (≈130 ka to 14 ka). The Linás de Broto depositional system consisted of a proglacial lake fed primarily by meltwater streams emanating from the small Sorrosal glacier and dammed by a lateral moraine of the Ara trunk glacier. The resulting glacio-fluvio-lacustrine sequence, around 55 m thick, is divided into five lithological units consisting of braided fluvial (gravel deposits), lake margin (gravel and sand deltaic deposits) and distal lake (silt and clay laminites) facies associations. Evolution of the depositional environment reflects three phases of progradation of a high-energy braided fluvial system separated by two phases of rapid expansion of the lake. Fluvial progradation occurred during short periods of ice melting. Lake expansion concurred with ice-dam growth of the trunk glacier. The first lake expansion occurred over a time range between 55 ± 9 ka and 49 ± 11 ka, and is consistent with the age of the Viu lateral moraine (49 ± 8 ka), which marks the maximum areal extent of the Ara glacier during the Last Glacial Cycle. These dates confirm that the maximum areal extent of the glacier occurred during Marine Isotope Stages 4 and 3 in the south-central Pyrenees, thus before the Last Glacial Maximum. The evolution of the Linás de Broto depositional system during this maximum glacier extent was modulated by climate oscillations in the northern Iberian Peninsula, probably related to latitudinal shifts of the atmospheric circulation in the southern North-Atlantic Ocean, and variations in summer insolation intensity

Alpha-protein kinase 3 (ALPK3)-truncating variants are a cause of autosomal dominant hypertrophic cardiomyopathy.

AIMS: The aim of this study was to determine the frequency of heterozygous truncating ALPK3 variants (ALPK3tv) in patients with hypertrophic cardiomyopathy (HCM) and confirm their pathogenicity using burden testing in independent cohorts and family co-segregation studies. METHODS AND RESULTS : In a discovery cohort of 770 index patients with HCM, 12 (1.56%) were heterozygous for ALPK3tv [odds ratio(OR) 16.01, 95% confidence interval (CI) 7.89-29.74, P < 8.36e-11] compared to the Genome Aggregation Database (gnomAD) population. In a validation cohort of 2047 HCM probands, 32 (1.56%) carried heterozygous ALPK3tv (OR 16.17, 95% CI 10.31-24.87, P < 2.2e-16, compared to gnomAD). Combined logarithm of odds score in seven families with ALPK3tv was 2.99. In comparison with a cohort of genotyped patients with HCM (n = 1679) with and without pathogenic sarcomere gene variants (SP+ and SP-), ALPK3tv carriers had a higher prevalence of apical/concentric patterns of hypertrophy (60%, P < 0.001) and of a short PR interval (10%, P = 0.009). Age at diagnosis and maximum left ventricular wall thickness were similar to SP- and left ventricular systolic impairment (6%) and non-sustained ventricular tachycardia (31%) at baseline similar to SP+. After 5.3 ± 5.7 years, 4 (9%) patients with ALPK3tv died of heart failure or had cardiac transplantation (log-rank P = 0.012 vs. SP- and P = 0.425 vs. SP+). Imaging and histopathology showed extensive myocardial fibrosis and myocyte vacuolation. CONCLUSIONS : Heterozygous ALPK3tv are pathogenic and segregate with a characteristic HCM phenotype

Caracterización de las válvulas hidráulicas de diafragma

Se propone un procedimiento para caracterizar la presión mínima de trabajo en válvulas hidráulicas de diafragma en función de las presiones aguas arriba, aguas abajo, y del volumen evacuado de la cámara. El caudal circulante tiene poca influencia en la presión mínima de trabajo. Otro parámetro estudiado es la pérdida de carga. Se ha visto que los requerimientos de presión de la Norma ISO 9644 (dos tercios de la presión nominal) pueden ser sustituidos por unas condiciones de apertura completa menos exigentes en presión. El parámetro k de pérdidas de carga singulares, para apertura completa, se ha visto que varía con el caudal y por tanto la representación de las pérdidas de carga en escala doble logarítmica no es exactamente una recta.A procedure to determine minimum working pressure in hydraulic diaphragm valves is presented. To fix this pressure is necessary to measure inlet and outlet pressures, and chamber evacuated volume. Discharge has a little influence on minimum working pressure. Other parameter studied was the head loss. Minimum pressure requirements established in ISO 9644 could be substituted by full opening conditions. Parameter k of minor losses varies with discharge, for full opening conditions

A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe

BACKGROUND: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. METHODS: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. RESULTS: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients’ median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. CONCLUSIONS: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes