Choice of the initial antiretroviral treatment for HIV-positive individuals in the era of integrase inhibitors

BACKGROUND: We aimed to describe the most frequently prescribed initial antiretroviral therapy (ART) regimens in recent years in HIV-positive persons in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) and to investigate factors associated with the choice of each regimen. METHODS: We analyzed initial ART regimens prescribed in adults participating in CoRIS from 2014 to 2017. Only regimens prescribed in >5% of patients were considered. We used multivariable multinomial regression to estimate Relative Risk Ratios (RRRs) for the association between sociodemographic and clinical characteristics and the choice of the initial regimen. RESULTS: Among 2874 participants, abacavir(ABC)/lamivudine(3TC)/dolutegavir(DTG) was the most frequently prescribed regimen (32.1%), followed by tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/elvitegravir(EVG)/cobicistat(COBI) (14.9%), TDF/FTC/rilpivirine (RPV) (14.0%), tenofovir alafenamide (TAF)/FTC/EVG/COBI (13.7%), TDF/FTC+DTG (10.0%), TDF/FTC+darunavir/ritonavir or darunavir/cobicistat (bDRV) (9.8%) and TDF/FTC+raltegravir (RAL) (5.6%). Compared with ABC/3TC/DTG, starting TDF/FTC/RPV was less likely in patients with CD4100.000 copies/mL. TDF/FTC+DTG was more frequent in those with CD4100.000 copies/mL. TDF/FTC+RAL and TDF/FTC+bDRV were also more frequent among patients with CD4<200 cells//muL and with transmission categories other than men who have sex with men. Compared with ABC/3TC/DTG, the prescription of other initial ART regimens decreased from 2014-2015 to 2016-2017 with the exception of TDF/FTC+DTG. Differences in the choice of the initial ART regimen were observed by hospitals' location. CONCLUSIONS: The choice of initial ART regimens is consistent with Spanish guidelines' recommendations, but is also clearly influenced by physician's perception based on patient's clinical and sociodemographic variables and by the prescribing hospital location

Murine in vitro cellular models to better understand adipogenesis and its potential applications

Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology

D-SAV360: A Dataset of Gaze Scanpaths on 360° Ambisonic Videos

&lt;p&gt;D-SAV360 is composed of 50 stereoscopic and 35 monoscopic 360º videos with ambisonic sound. We provide the collected gaze data from 87 participants visualizing the videos, the computed saliency maps, the estimated optical flow (obtained using RAFT), the estimated depth, the computed Audio Energy Maps, and the individual recordings from the 360º camera rig (6x fisheye recordings).&lt;/p&gt;&lt;ul&gt;&lt;li&gt;&lt;strong&gt;Project page, documentation and additional information&lt;/strong&gt;: &lt;a href="https://graphics.unizar.es/projects/D-SAV360/"&gt;https://graphics.unizar.es/projects/D-SAV360/&lt;/a&gt;&lt;/li&gt;&lt;li&gt;If you find our dataset useful,&lt;strong&gt; please cite the corresponding publication&lt;/strong&gt;:&nbsp;&lt;br&gt;Bernal-Berdun, E., Martin, D., Malpica, S., Perez, P.J., Gutierrez, D., Masia, B. and Serrano, A., 2023. D-SAV360: A Dataset of Gaze Scanpaths on 360° Ambisonic Videos. IEEE Transactions on Visualization and Computer Graphics. DOI: &lt;a href="https://doi.org/10.1109/TVCG.2023.3320237"&gt;10.1109/TVCG.2023.3320237&lt;/a&gt;&lt;/li&gt;&lt;li&gt;&lt;strong&gt;Note&lt;/strong&gt;: The individual recordings from&nbsp;the 360º camera rig (6x fisheye recordings) are too large for the allowed size. Please visit the project page if you are interested in this data.&lt;/li&gt;&lt;/ul&gt

High‐Resolution Mass Spectrometry Associated with Data Mining Tools for the Detection of Pollutants and Chemical Characterization of Honey Samples

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