Endogenous Growth, Capital Utilization and Depreciation

We study the one sector model of growth when a linear production technology is combined with adjustment costs and a technology for capital maintenance. Agents are allowed to under-use the installed capital and to vary the depreciation rate. This economy decides endogenously how much resources devotes to the accumulation of new capital and how much to maintenance and repair activities. We find as striking results that the long-run depreciation and capital utilization rates are positively related to the population growth rate, and that both depend negatively on the initial conditions. The long-run growth rate appears positively correlated with the depreciation rate.Maintenance; Depreciation; Capital Utilization; Endogenous Growth

Renewable Natural Resources and Endogenous Growth

We study a two-sector endogenous growth model where a single consumption good is obtained using a renewable resource in combination with physical capital. Both inputs are essential for production and technical substitutes. In this context we analyze the issues of sustainability, long-run and short-run growth as well as convergence, associated with the competitive equilibrium solution trajectories. We show that efficiency, long-run growth and sustainability are both compatible in a natural resource based production economy.Natural Capital, Endogenous Growth, Sustainability, Convergence

Closed-Form Solution for a Two-Sector Endogenous Growth Model with two Controls

In this paper we show a method for solving in closed form a particular family of four-dimension non-linear modified Hamiltonian dynamic systems, with two states and two co-states and two co-states, which arises from a two-sector endogenous growth model where the physical capital stock is combined with a renewable natural capital stock as essential inputs for productionNon-Linear Dynamic System, Analytical Solution, Endogenous Growth, Transitional Dynamics

Non Catastrophic Endogenous Growth with Pollution and Abatment

When there are pollution externalities the competitive equilibrium is not Pareto-optimal nor environmentally sustainable even if abatment activities are endogenously decided. In this paper we introduce the possibility of an ecological catastrophe like the one predicted by the global climate change, imposing the constraint of an upper-limit to the pollutants stock. We characterize this socially optimal soclution and study conditions for the sustainability of the balanced growth path. We find a trade-off between environmental quality and growth. The rate of growth depends negatively on the weight of environmental care in the utility function and positively on the population growth rate. We show that the emissions reduction recommended in the Kioto protocol is an appropriate policy to avoid the ecological catastrophe and ensure global efficiency and positive long-run growth.Environment; Externalities; Optimal Growth, Ecological Catastrophe; Sustainability

Demographic Transition Environmental Concern and the Kuznets Curve

In an endogenous growth model with pollution and abatement we characterize the socially optimal solution. We find that the rate of growth depends negatively on the weight of environmental care in utility and positively on the population growth rate. We also find a trade-off between growth and environmental quality beyond which an environmental Kuznets curve is derived in the long term. This one emerges from the implications of the demographic transition for the rate of population growth, and the accompanying variation in the willingness to pay for environmental quality as the economy develops.Optimal Growth; Environment; Population Growth; Preferences

A Cholinergic Synaptically Triggered Event Participates in the Generation of Persistent Activity Necessary for Eye Fixation

An exciting topic regarding integrative properties of the nervous system is how transient motor commands or brief sensory stimuli are able to evoke persistent neuronal changes, mainly as a sustained, tonic action potential firing. A persisting firing seems to be necessary for postural maintenance after a previous movement. We have studied in vitro and in vivo the generation of the persistent neuronal activity responsible for eye fixation after spontaneous eye movements. Rat sagittal brainstem slices were used for the intracellular recording of prepositus hypoglossi (PH) neurons and their synaptic activation from nearby paramedian pontine reticular formation (PPRF) neurons. Single electrical pulses applied to the PPRF showed a monosynaptic glutamatergic projection on PH neurons, acting on AMPA-kainate receptors. Train stimulation of the PPRF area evoked a sustained depolarization of PH neurons exceeding (by hundreds of milliseconds) stimulus duration. Both duration and amplitude of this sustained depolarization were linearly related to train frequency. The train-evoked sustained depolarization was the result of interaction between glutamatergic excitatory burst neurons and cholinergic mesopontine reticular fibers projecting onto PH neurons, because it was prevented by slice superfusion with cholinergic antagonists and mimicked by cholinergic agonists. As expected, microinjections of cholinergic antagonists in the PH nucleus of alert behaving cats evoked a gaze-holding deficit consisting of a re-centering drift of the eye after each saccade. These findings suggest that a slow, cholinergic, synaptically triggered event participates in the generation of persistent activity characteristic of PH neurons carrying eye position signals

Modulating motor learning through transcranial direct-current stimulation: An integrative view

Motor learning consists of the ability to improve motor actions through practice playing a major role in the acquisition of skills required for high-performance sports or motor function recovery after brain lesions. During the last decades, it has been reported that transcranial direct-current stimulation (tDCS), consisting in applying weak direct current through the scalp, is able of inducing polarity-specific changes in the excitability of cortical neurons. This low-cost, painless and well-tolerated portable technique has found a wide-spread use in the motor learning domain where it has been successfully applied to enhance motor learning in healthy individuals and for motor recovery after brain lesion as well as in pathological states associated to motor deficits. The main objective of this mini-review is to offer an integrative view about the potential use of tDCS for human motor learning modulation. Furthermore, we introduce the basic mechanisms underlying immediate and long-term effects associated to tDCS along with important considerations about its limitations and progression in recent years

Nesting Success of Kemp’s Ridley Sea Turtles, Lepidochelys kempi, at Rancho Nuevo, Tamaulipas, Mexico, 1982–2004

The Kemp’s ridley sea turtle, Lepidochelys kempi, was on the edge of extinction owing to a combination of intense egg harvesting and incidental capture in commercial fishing trawls. Results from a cooperative conservation strategy initiated in 1978 between Mexico and the United States to protect and restore the Kemp’s ridley turtle at the main nesting beach at Rancho Nuevo, Tamaulipas, Mexico are assessed. This strategy appears to be working as there are signs that the species is starting to make a recovery. Recovery indicators include: 1) increased numbers of nesting turtles, 2) increased numbers of 100+ turtle nesting aggregations (arribadas), 3) an expanding nesting season now extending from March to August, and 4) significant nighttime nesting since 2003. The population low point at Rancho Nuevo was in 1985 (706 nests) and the population began to significantly increase in 1997 (1,514 nests), growing to over 4,000 nests in 2004. The size and numbers of arribadas have increased each year since 1983 but have yet to exceed the 1,000+ mark; most arribadas are still 200–800+ turtles

Dynamic regulation of mitochondrial metabolism as a strategy to maximize mAb production in industrial CHO cell cultures

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SEOM clinical guideline for the management of cutaneous melanoma (2020)

Tractament adjuvant; Melanoma; EscenificacióAdjuvant treatment; Melanoma; StagingTratamiento adyuvante; Melanoma; EscenificaciónMelanoma affects about 6000 patients a year in Spain. A group of medical oncologists from Spanish Society of Medical Oncology (SEOM) and Spanish Multidisciplinary Melanoma Group (GEM) has designed these guidelines to homogenize the management of these patients. The diagnosis must be histological and determination of BRAF status has to be performed in patients with stage ≥ III. Stage I–III resectable melanomas will be treated surgically. In patients with stage III melanoma, adjuvant treatment with immunotherapy or targeted therapy is also recommended. Patients with unresectable or metastatic melanoma will receive treatment with immunotherapy or targeted therapy, the optimal sequence of these treatments remains unclear. Brain metastases require a separate consideration, since, in addition to systemic treatment, they may require local treatment. Patients must be followed up closely to receive or change treatment as soon as their previous clinical condition changes, since multiple therapeutic options are available