An Examination of Power in a Triadic Model of parent–child–pediatrician relationships related to early childhood gender development

In this paper, the authors introduce the Triadic Model of Pediatric Care, an innovative conceptual framework for pediatric practice with transgender and gender diverse children. The Triadic Model of Pediatric Care consists of three experts—pediatricians, primary caregiver(s), and children—who each possess unique insights, knowledge, and decision-making power. This model guides pediatricians to provide gender-affirming care that acknowledges children as experts of their own experience and worthy of bodily autonomy, while also working to ensure primary caregiver(s) have the information and support necessary to provide a safe and nurturing developmental environment for their child. The authors provide a recommendation for how the Triadic Model of Pediatric Care might be applied in a pediatric healthcare setting and conclude with a summary of the model\u27s implications, limitations, and future directions

Quasi-static magnetization dynamics in a compensated ferrimagnetic half-metal -- Mn2_2Rux_xGa

Exploring anisotropy and diverse magnetization dynamics in specimens with vanishing magnetic moments presents a significant challenge using traditional magnetometry, as the low resolution of existing techniques hinders the ability to obtain accurate results. In this study, we delve deeper into the examination of magnetic anisotropy and quasi-static magnetization dynamics in \mrg\,(MRG) thin films, as an example of a compensated ferrimagnetic half-metal, by employing anomalous Hall effect measurements within a tetragonal crystal lattice system. Our research proposes an innovative approach to accurately determine the complete set of anisotropy constants of these MRG thin films. To achieve this, we perform anomalous Hall voltage curve fitting, using torque models under the macrospin approximation, which allow us to obtain out-of-plane anisotropy constants $K_1=4.0\times10^4$ J m$^{-3}$ ($K_1/M=0.655$\,T) and $K_2=2.54\times10^4$ J m$^{-3}$ ($K_2/M=0.416$\,T), along with a weaker in-plane anisotropy constant $K_3=3.48\times10^3$ J m$^{-3}$ ($K_3/M=0.057$\,T). By additionally employing first-order reversal curves (FORC) and classical Preisach hysteresis (hysterons) models, we are able to validate the efficacy of the macrospin model in capturing the magnetic behavior of MRG thin films. Furthermore, our investigation substantiates that the complex quasi-static magnetization dynamics of MRG thin films can be effectively modelled using a combination of hysteronic and torque models. This approach facilitates the exploration of both linear and non-linear quasi-static magnetization dynamics, in the presence of external magnetic field and/or current-induced effective fields, generated by the spin-orbit torque and spin transfer torque mechanisms.Comment: 14 pages, 10 figure

Groundnut in ICRISAT programmes

Groundnut (Arachis hypogaea L.) is one of the three legume crops for which ICRISAT is mandated to develop and improve. ICRISAT is also designated as a world repoitory of germplasm with over 14 000 accessions of cultivated groundnut and 450 accessions of wild Arachis species currently held in public (rusL Groulltillut is an anllual crop and its seeds <Ire a rich source of edible oil und protein. Groulldnut is grown in over 100 COUll tries with a to(al estimated area of21.8 million ha and production in shell of28.5 lllil1ion t. Asiu (25 countries) with 63.4% of the area produces 7 I .7% of the world groundnut production. It is followed by Africu (46 countries) with 31.3% of the area and 18.6% 0[' the production...........

Groundnut Virus Diseases in Africa Summary and recommendations of the Sixth Meeting of the International Working Group 18 - 19 Mar 1996, Agricultural Research Council, Plant Protection Research Institute, Pretoria, South Africa

The International Working Group Meeting on groundnut viruses in Africa reviewed progress made on the detection, identification, characterization, and management of groundnut viruses in Africa, with special emphasis on rosette and clump viruses. Country representatives summarized the status of research on groundnut viruses in their countries. In order to accomplish integrated management of rosette and clump virus diseases, it was agreed that consolidated efforts should be made to understand their epidemiology. Among the important aspects discussed were the provision of diagnostic aids and training in the identification and detection of viruses for the national agricultural research systems in Africa, and strengthening of laboratory facilities. Scientists from Burkina Faso, Kenya, Malawi, Nigeria, South Africa, and Zimbabwe, and from Belgium, Germany, India, UK, and USA attended the meeting, which was the first gathering of so many plant virologists in South Africa

Recent Studies on Peanut Bud Necrosis Disease: Proceedings of a Meeting 20 Mar 1995

The current status of research on peanut bud necrosis disease caused by the peanut bud necrosis virus and transmitted by Thrips palmi is reviewed. Recent advances in the genome structure, host range, transmission, and spread of tospoviruses wi t h emphasis on the peanut bud necrosis virus are discussed. Epidemiology of the disease and resistance to both the vector and the virus are reviewed in detail. Agronomically acceptable varieties wi th resistance to either the vector or to the vector and the virus are now available

Farmers' participatory integrated management of foliar diseases of groundnut

Late leaf spot (LLS) caused by Phaeoisariopsis personata [(Berk and Curt) v. Arx = Cercosporidium personatum (Berk. & Curt.) Deighton] and rust caused by Puccinia arachidis (Speg.) are the two most destructive fungal foliar diseases of groundnut worldwide. Together, these two diseases can cause more than 50% yield loss in groundnut in many countries. Foliar disease management in groundnut often involves indiscriminate use of chemicals or total reliance on host plant resistance (HPR). On-station experiments on integrated disease management (IDM) at ICRISAT-Patancheru, India, have clearly demonstrated that when moderate levels of HPR are combined with seed treatment and affordable levels of chemical control, expected yields and economic returns are higher than obtained with chemical control of susceptible genotypes. We evaluated the performance of this combination in on-farm farmer-participatory research. The groundnut genotypes were ICGV 89104, ICGV 91114, TMV 2 and a local cultivar. Thirty farmers from Anantapur, Kurnool, and Nalgonda districts in the state of Andhra Pradesh, India, conducted the experiments during the 1995 and 1996 rainy seasons. Local agronomic practices were followed. Experiments were conducted under both high disease pressure [nonintegrated disease management (non-IDM) i.e. natural] and low disease pressure [integrated disease management (IDM), i.e. seed treatment and fungicide, chlorothalonil sprayed once at 60 days after sowing, d.a.s.]. The severities of LLS and rust on test genotypes were significantly lower than on TMV 2 and the local cultivar up to 65 d.a.s. The increase in pod yield over the local cultivar and TMV 2 in IDM plots was 60% in ICGV 89104, and 55% in ICGV 91114. Farmers preferred these two genotypes because of their close phenotypic similarity to the local cultivar. Our studies also suggest that any technology developed for groundnut should offer a clear yield and foliar disease resistance advantage over farmers' current practices

Enzymatic Regulation of Protein-Protein Interactions in Artificial Cells

Membraneless organelles are important for spatial organization of proteins and regulation of intracellular processes. Proteins can be recruited to these condensates by specific protein–protein or protein–nucleic acid interactions, which are often regulated by post-translational modifications. However, the mechanisms behind these dynamic, affinity-based protein recruitment events are not well understood. Here, a coacervate system that incorporates the 14-3-3 scaffold protein to study enzymatically regulated recruitment of 14-3-3-binding proteins is presented, which mostly bind in a phosphorylation-dependent manner. Synthetic coacervates are efficiently loaded with 14-3-3, and phosphorylated binding partners, such as the c-Raf pS233/pS259 peptide (c-Raf), show 14-3-3-dependent sequestration with up to 161-fold increase in local concentration. The c-Raf domain is fused to green fluorescent protein (GFP-c-Raf) to demonstrate recruitment of proteins. In situ phosphorylation of GFP-c-Raf by a kinase leads to enzymatically regulated uptake. The introduction of a phosphatase into coacervates preloaded with the phosphorylated 14-3-3-GFP-c-Raf complex results in a significant cargo efflux mediated by dephosphorylation. Finally, the general applicability of this platform to study protein–protein interactions is demonstrated by the phosphorylation-dependent and 14-3-3-mediated active reconstitution of a split-luciferase inside artificial cells. This work presents an approach to study dynamically regulated protein recruitment in condensates, using native interaction domains.</p

Aflatoxin Contamination of Groundnut: Prospects for a Genetic Solution through Conventional Breeding

Af latoxin contamination of groundnut is a serious problem in most groundnut-producing countries. The aflatoxin-producing fungi, Aspergillus flavus and A. parasiticus, can invade groundnut seed in the field before harvest, during postharvest drying and curing, and in storage. The semi-arid tropical environment is conducive to preharvest contamination when the crop experiences drought before harvest, whereas in wet and humi d areas, postharvest contamination is more prevalent. Af latoxin contamination can be minimized by adopting some cultural, produce-handling, and storage practices. However, these practices have not been widely adopted by small farmers in developing countries which contribute about 60% of the world's groundnut product ion. Cultivars resistant to seed invasion by aflatoxin-producing fungi or to aflatoxin product ion woul d be of great value to farmers in both developed and developing countries. Therefore, breeding for resistance to aflatoxin-producing fungi and/or aflatoxin product ion can play a significant role in preventing aflatoxin contamination in groundnut , consequent economic losses, and health hazards. The alleviation of aflatoxin contamination through genetic manipulation has been at tempted since the mid 1970s. In spite of the significant progress achieved to date, these efforts have not resulted in complete freedom f rom aflatoxin contamination. The current status and future prospects of genetic solutions to the aflatoxin contamination problem are briefly discussed in this paper