1,377 research outputs found
Paths reunited: initiation of the classical and lectin pathways of complement activation
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago. Nevertheless, knowledge is still incomplete, especially with regard to the interactions between its subcomponents C1q, C1r and C1s that trigger activation upon binding to a microbial target. Recent studies have provided new insights into these interactions, and have revealed unexpected parallels with initiating complexes of the lectin pathway of complement: MBLâMASP and ficolinâMASP. Here, we develop and expand these concepts and delineate their implications towards the key aspects of complement activation via the classical and lectin pathways
Machine learning the deuteron
We use machine learning techniques to solve the nuclear two-body bound state
problem, the deuteron. We use a minimal one-layer, feed-forward neural network
to represent the deuteron S- and D-state wavefunction in momentum space, and
solve the problem variationally using ready-made machine learning tools. We
benchmark our results with exact diagonalisation solutions. We find that a
network with 6 hidden nodes (or 24 parameters) can provide a faithful
representation of the ground state wavefunction, with a binding energy that is
within 0.1% of exact results. This exploratory proof-of-principle simulation
may provide insight for future potential solutions of the nuclear many-body
problem using variational artificial neural network techniques.Comment: 8 pages, 7 figures - Final published version including extended
analysis and appendice
Determination of positron annihilation lifetime spectroscopy instrument timing resolution function and source terms using standard samples
Bifurcated polarization rotation in bismuth-based piezoelectrics
ABO3 perovskite-type solid solutions display a large variety of structural and physical properties, which can be tuned by chemical composition or external parameters such as temperature, pressure, strain, electric, or magnetic fields. Some solid solutions show remarkably enhanced physical properties including colossal magnetoresistance or giant piezoelectricity. It has been recognized that structural distortions, competing on the local level, are key to understanding and tuning these remarkable properties, yet, it remains a challenge to experimentally observe such local structural details. Here, from neutron pair-distribution analysis, a temperature-dependent 3D atomic-level model of the lead-free piezoelectric perovskite Na0.5Bi0.5TiO3 (NBT) is reported. The statistical analysis of this model shows how local distortions compete, how this competition develops with temperature, and, in particular, how different polar displacements of Bi3+ cations coexist as a bifurcated polarization, highlighting the interest of Bi-based materials in the search for new lead-free piezoelectrics
Revised structural phase diagram of (Ba0.7Ca0.3TiO3)-(BaZr0.2Ti0.8O3)
The temperature-composition phase diagram of barium calcium titanate zirconate (x(Ba0.7Ca0.3TiO3)(1-x)(BaZr0.2Ti0.8O3); BCTZ) has been reinvestigated using high-resolution synchrotron x-ray powder diffraction. Contrary to previous reports of an unusual rhombohedral-tetragonal phase transition in this system, we have observed an intermediate orthorhombic phase, isostructural to that present in the parent phase, BaTiO3, and we identify the previously assigned T-R transition as a T-O transition. We also observe the O-R transition coalescing with the previously observed triple point, forming a phase convergence region. The implication of the orthorhombic phase in reconciling the exceptional piezoelectric properties with the surrounding phase diagram is discussed
How do root and soil characteristics affect the erosion-reducing potential of plant species?
Plant roots can be very effective in stabilizing the soil against concentrated flow erosion. So far, most research on the erosion-reducing potential of plant roots was conducted on loamy soils. However susceptible to incisive erosion processes, at present, no research exists on the effectiveness of plant roots in reducing concentrated flow erosion rates in sandy soils. Therefore, the prime objective of this study was to assess the erosion-reducing potential of both fibrous and tap roots in sandy soils. Furthermore, we investigated potential effects of root diameter, soil texture and dry soil bulk density on the erosion-reducing potential of plant roots. Therefore, flume experiments conducted on sandy soils (this study) were compared with those on sandy loam and silt loam soils (using the same experimental set up). Results showed that plant roots were very efficient in reducing concentrated flow erosion rates in sandy soils compared to root-free bare soils. Furthermore, our results confirmed that fibrous roots were more effective compared to (thick) tap roots. Dry soil bulk density and soil texture also played a significant role. As they were both related to soil cohesion, the results of this study suggested that the effectiveness of plant roots in controlling concentrated flow erosion rates depended on the apparent soil cohesion. The nature of this soil type effect depended on the root-system type: fine root systems were most effective in non-cohesive soils while tap root systems were most effective in cohesive soils. For soils permeated with a given amount of fibrous roots, an increase of soil bulk density seemed to hamper the effectiveness of roots to further increase soil cohesion and reduce erosion rates. In soils reinforced by tap root systems, the erosion-reducing power of the roots depended on sand content: the higher the percentage of sand, the smaller the erosion-reducing effect for a given amount of roots. This was attributed to more pronounced vortex erosion around the thicker tap roots in non-cohesive soils, increasing soil erosion rates. The results presented in this study could support practitioners to assess the likely erosion-reducing effects of plant root systems based on both root and soil characteristics
Structural and Magnetic Investigations of Single-Crystals of the Neodymium Zirconate Pyrochlore, Nd2Zr2O7
We report structural and magnetic properties studies of large high quality
single-crystals of the frustrated magnet, NdZrO. Powder x-ray
diffraction analysis confirms that NdZrO adopts the pyrochlore
structure. Room-temperature x-ray diffraction and time-of-flight neutron
scattering experiments show that the crystals are stoichiometric in composition
with no measurable site disorder. The temperature dependence of the magnetic
susceptibility shows no magnetic ordering at temperatures down to 0.5 K. Fits
to the magnetic susceptibility data using a Curie-Weiss law reveal a
ferromagnetic coupling between the Nd moments. Magnetization versus field
measurements show a local Ising anisotropy along the axes of the
Nd ions in the ground state. Specific heat versus temperature
measurements in zero applied magnetic field indicate the presence of a thermal
anomaly below K, but no evidence of magnetic ordering is observed down
to 0.5 K. The experimental temperature dependence of the single-crystal bulk dc
susceptibility and isothermal magnetization are analyzed using crystal field
theory and the crystal field parameters and exchange coupling constants
determined.Comment: 10 pages, 6 figures, 4 tables. Accepted for publication in Physical
Review
Operation Moshtarak and the manufacture of credible, âheroicâ warfare
Richard Lance Keeble argues that Fleet Streetâs coverage of the Afghan conflict has served largely to promote the interests of the military/industrial/media complex â and marginalise the views of the public who have consistently appealed in polls for the troops to be brought back hom
First-Order Reorientation of the Flux-Line Lattice in CaAlSi
The flux line lattice in CaAlSi has been studied by small angle neutron
scattering. A well defined hexagonal flux line lattice is seen just above Hc1
in an applied field of only 54 Oe. A 30 degree reorientation of this vortex
lattice has been observed in a very low field of 200 Oe. This reorientation
transition appears to be of first-order and could be explained by non-local
effects. The magnetic field dependence of the form factor is well described by
a single penetration depth of 1496(1) angstroms and a single coherence length
of 307(1) angstroms at 2 K. At 1.5 K the penetration depth anisotropy is 2.7(1)
with the field applied perpendicular to the c axis and agrees with the
coherence length anisotropy determined from critical field measurements.Comment: 5 pages including 6 figures, to appear in Physical Review Letter
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