Ethyl 4-(dimethyl­amino)benzoate

Mol­ecules of the title compound, C11H15NO2, are essentially planar (r.m.s. deviation = 0.035 Å) and are linked into a chain along the a axis by weak C—H⋯O hydrogen bonds

1,1′-[4-(2,4-Dichloro­phen­yl)-2,6-di­methyl-1,4-di­hydro­pyridine-3,5-di­yl]diethanone

In the title compound, C17H17Cl2NO2, the central 1,4-dihydro­pyridine ring adopts a flattened-boat conformation. The ethanone substituents of the dihydro­pyridine ring at positions 3 and 5 have synperiplanar (cis) or anti­periplanar (trans) conformations with respect to the adjacent C=C bonds in the dihydro­pyridine ring. The 2,4-dichloro­phenyl ring is almost planar [r.m.s. deviation = 0.0045 (1) Å] and almost perpendicular [89.27 (3)°] to the mean plane of the dihydro­pyridine ring. In the crystal, an N—H⋯O hydrogen bond links mol­ecules into a zigzag chain along the ac diagonal. C—H⋯Cl contacts form centrosymmetric dimers and additional weak C—H⋯O contacts further consolidate the packing

rac-2-Hy­droxy-2-(2-oxocyclo­pent­yl)-1H-indene-1,3(2H)-dione

In the title compound, C14H12O4, the indene unit is essentially planar [r.m.s. deviation = 0.0309 (1) Å] and the cyclo­penta­none ring adopts a twist form. In the crystal, mol­ecules are joined via pairs of O—H⋯O hydrogen bonds into centrosymmetric dimers

l-Asparagine–l-tartaric acid (1/1)

In the title compound, C4H8N2O3·C4H6O6, the amino acid mol­ecule exists as a zwitterion and the carb­oxy­lic acid in an un-ionized state. The tartaric acid mol­ecules are linked into layers parallel to the ab plane by O—H⋯O hydrogen bonds. The amino acid mol­ecules are also linked into layers parallel to the ab plane by N—H⋯O and C—H⋯O hydrogen bonds. The alternating tartaric acid and amino acid layers are linked into a three-dimensional framework by N—H⋯O and O—H⋯O hydrogen bonds

3-Acetyl-6-chloro-4-phenyl­quinolin-2(1H)-one

The title compound, C17H12ClNO2, crystallizes with two mol­ecules in the asymmetric unit. The main conformational difference between these two mol­ecules is the dihedral angle between the phenyl ring and the quinoline ring system [70.5 (1)° and 65.5 (1) Å]. The crystal packing is stabilized by N—H⋯O hydrogen bonds

(E)-1,1,4,4-Tetra­phenyl­but-2-yne-1,4-diol

The mol­ecule of the title compound, C28H22O2, is centrosymmetric with the inversion centre located at the mid-point of the C C bond [1.178 (5) Å]. The hydroxyl groups therefore lie on either side of the mol­ecule. The crystal structure is stabilized by O—H⋯O hydrogen bonds, leading to the formation of a linear supra­molecular chain along the b axis

5′′-(4-Chloro­benzyl­idene)-4′-(4-chloro­phen­yl)-5-fluoro-1′,1′′-dimethyl­indoline-3-spiro-2′-pyrrolidine-3′-spiro-3′′-piperidine-2,4′′-dione

The piperidine ring of the title compound, C30H26Cl2FN3O2, adopts a twisted chair conformation. The pyrrolidine ring has a twisted envelope structure with the N atom at the flap [displaced by 0.592 (3) Å]. The fluoro­oxindole, chloro­phenyl and chloro­benzyl­idene groups are planar with r.m.s. deviations of 0.0348, 0.0048 and 0.0048 Å, respectively. The structure is stabilized by inter­molecular N—H⋯O hydrogen bonds

Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives

<p>Abstract</p> <p>Background</p> <p>The spiro- indole-pyrrolidine ring system is a frequently encountered structural motif in many biologically important and pharmacologically relevant alkaloids. The derivatives of spirooxindole ring systems are used as antimicrobial, antitumour agents and as inhibitors of the human NKI receptor besides being found in a number of alkaloids like horsifiline, spirotryprostatin and (+) elacomine. The recently discovered small-molecule MDM2 inhibitor MI-219 and its analogues are in advanced preclinical development as cancer therapeutics.</p> <p>Results</p> <p>In the crystal structures of the two organic compounds, 4'-Nitro-3',5'-diphenylspiro[indoline-3,2'-pyrrolidin]-2-one and 3'-(4-Methoxyphenyl)- 4'-nitro -5'-phenylspiro[indoline-3,2'-pyrrolidin]-2-one, N-H···O hydrogen bonds make the R²₂(8) ring motif. Further, the structures are stabilized by intermolecular hydrogen bonds.</p> <p>Conclusion</p> <p>The crystal structures of 4'-Nitro-3',5'-diphenylspiro[indoline-3,2'-pyrrolidin]-2-one and 3'-(4-Methoxyphenyl)- 4'-nitro -5'-phenylspiro[indoline-3,2'-pyrrolidin]-2-one have been investigated in detail. In both the compounds, the R²₂(8) motif is present. Due to the substitution of methoxyphenyl instead of phenyl ring, the entire configuration is inverted with respect to the 2-oxyindole ring.</p

Synthesis, growth, crystal structure and characterization of a new organic material: Glycine glutaric acid

Glycine glutaric acid, a new organic compound has been synthesized and good quality single crystals were grown by slow evaporation technique. The structure of the grown crystal was elucidated by using single crystal XRD. The presence of the functional groups was confirmed by using FT-IR spectroscopy. The optical transparency was studied by using UV–vis spectrophotometer and it was found that the crystal is having high optical transparency. The thermal stability of the crystal was studied by using thermo-gravimetric and differential thermal analyses and found that it is stable up to 150 ◦ C. The room temperature dielectric studies were also carried out over the wide frequency range: 10 mHz to 10 MHz