Clinical experience with an epoxy resin adhesive for direct bonding of orthodontic attachments*

KIMAn epoxy resin formulation developed in the Dental Research Unit has been subjected to further clinical trials. Six patients, were used in the study. They were divided into two age groups and all the teeth, including the first molars, bonded. Rubber dam was used to keep the crowns dry during the setting period of the resin. In the younger group the mean failure rates were 27 per cent for anterior teeth and 70 per cent for the first molars. In the older group these rates were 11 per cent for incisors, 11 per cent for canines, 20 per cent for premolars and 20 per cent for first molars. While no figures are available in the literature relating to direct bonding to first molars, the results obtained in this study for the other teeth compare favourably with data previously published by other authors after trials using other types of cement

Report of the Horse Mackerel Exchange and Workshop 2006

Following a recommendation from PGCCDBS, a workshop on age calibration of horse mackerel was carried out. The workshop was preceded by an exchange. The objectives were: to improve the quality of horse mackerel readings by international calibration. In particular, attempt to resolve the observed differences between countries. Estimate the accuracy and precision of the age readings before and after the intercalibration. Take into account differences between areas and methods. Training of new horse mackerel readers

Towards a methodology for the engineering of event-driven process applications

Successful applications of the Internet of Things such as smart cities, smart logistics, and predictive maintenance, build on observing and analyzing business-related objects in the real world for business process execution and monitoring. In this context, complex event processing is increasingly used to integrate events from sensors with events stemming from business process management systems. This paper describes a methodology to combine the areas and engineer an event-driven logistics processes application. Thereby, we describe the requirements, use cases and lessons learned to design and implement such an architecture

Evidence of a sudden increase in α-chloralose poisoning in dogs and cats in the Netherlands between 2018 and 2021

BACKGROUND: After changes in European Union biocide legislation, the Dutch Poisons Information Center observed a strong increase in information requests concerning dogs and cats exposed to α-chloralose. To investigate whether α-chloralose-based rodenticides are safe for non-professional use, additional information regarding poisoning scenarios and clinical course was collected. METHODS: Veterinarians reporting α-chloralose exposure over a 2.5-year period were contacted by mail for follow-up information concerning exposure scenario, product formulation, clinical course and treatment, and outcome. In total, information was collected for 96 dogs and 41 cats. RESULTS: Fifty-three of 96 dogs and 17 of 19 cats known to have been exposed to α-chloralose-based rodenticides developed signs of central nervous system (CNS) depression or sensory-induced CNS excitation. Mortality in dogs and cats following exposure was 1% and 18%, respectively. An additional 22 cats presented with clinical signs suggestive of α-chloralose poisoning, with a mortality of 5%. LIMITATIONS: Exposure to α-chloralose was not confirmed by biochemical analyses. CONCLUSION: Dogs and especially cats were at risk of poisoning from α-chloralose. If criteria such as acute toxicity and risk of (secondary) poisoning are applied during the approval of α-chloralose-based rodenticides, similar to anticoagulant-based rodenticides, it can be concluded that α-chloralose is also not safe for non-professional use

Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials".

Pharmacolog

Formal Reasoning on Natural Language Descriptions of Processes

The existence of unstructured information that describes processes represents a challenge in organizations, mainly because this data cannot be directly referred into process-aware ecosystems due to ambiguities. Still, this information is important, since it encompasses aspects of a process that are left out when formalizing it on a particular modelling notation. This paper picks up this challenge and faces the problem of ambiguities by acknowledging its existence and mitigating it. Specifically, we propose a framework to partially automate the elicitation of a formal representation of a textual process description, via text annotation techniques on top of natural language processing. The result is the ATDP language, whose syntax and semantics are described in this paper. ATDP allows to explicitly cope with several interpretations of the same textual description of a process model. Moreover, we link the ATDP language to a formal reasoning engine and show several use cases. A prototype tool enabling the complete methodology has been implemented, and several examples using the tool are provided.Peer ReviewedPostprint (author's final draft

Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65.

Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide. Nuclear factor kappa B (NF-κB) transcription factors play crucial roles in clearance of invading viruses through activation of many physiological processes. Previous investigation showed that HBoV infection could significantly upregulate the level of TNF-α which is a strong NF-κB stimulator. Here we investigated whether HBoV proteins modulate TNF-α-mediated activation of the NF-κB signaling pathway. We showed that HBoV NS1 and NS1-70 proteins blocked NF-κB activation in response to TNF-α. Overexpression of TNF receptor-associated factor 2 (TRAF2)-, IκB kinase alpha (IKKα)-, IκB kinase beta (IKKβ)-, constitutively active mutant of IKKβ (IKKβ SS/EE)-, or p65-induced NF-κB activation was inhibited by NS1 and NS1-70. Furthermore, NS1 and NS1-70 didn't interfere with TNF-α-mediated IκBα phosphorylation and degradation, nor p65 nuclear translocation. Coimmunoprecipitation assays confirmed the interaction of both NS1 and NS1-70 with p65. Of note, NS1 but not NS1-70 inhibited TNF-α-mediated p65 phosphorylation at ser536. Our findings together indicate that HBoV NS1 and NS1-70 inhibit NF-κB activation. This is the first time that HBoV has been shown to inhibit NF-κB activation, revealing a potential immune-evasion mechanism that is likely important for HBoV pathogenesis