Influencia de un trabajo de flexibilidad en las clases de educación física en primaria

El objetivo de este trabajo fue analizar los efectos de un entrenamiento de seis semanas sobre la flexibilidad en niños de Primaria. Ochenta alumnos se distribuyeron en un grupo experimental (GE) y un grupo control (GC). Tras 18 sesiones de entrenamiento de trabajo de la flexibilidad se mejoró el rendimiento en el sit and reach (22.5%, p<0.001) y en la flexión profunda del cuerpo (10.4%, p<0.001). Estos resultados deben ser tenidos en cuenta especialmente en aquellos alumnos con problemas o patologías musculares en los que la mejora de la flexibilidad sea recomendable

Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions

Financial support from the Spanish Ministry of Economy and Competitiveness (MINECO, Project CTQ2016-75752-R) is gratefully acknowledged. A.M.-I. thanks MINECO for a predoctoral fellowship inside the FPI program

Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.

Plasmodium falciparum, the causative agent of malaria, relies extensively on glycolysis coupled with homolactic fermentation during its blood-borne stages for energy production. Selective inhibitors of the parasite lactate dehydrogenase (LDH), central to NAD(+) regeneration, therefore potentially provide a route to new antimalarial drugs directed against a novel molecular target. A series of heterocyclic, azole-based compounds are described that preferentially inhibit P. falciparum LDH at sub-micromolar concentrations, typically at concentrations about 100-fold lower than required for human lactate dehydrogenase inhibition. Crystal structures show these competitive inhibitors form a network of interactions with amino acids within the active site of the enzyme, stacking alongside the nicotinamide ring of the NAD(+) cofactor. These compounds display modest activity against parasitized erythrocytes, including parasite strains with known resistance to existing anti-malarials and against Plasmodium berghei in BALB/c mice. Initial toxicity data suggest the azole derivatives have generally low cytotoxicity, and preliminary pharmoco-kinetic data show favorable bioavailability and circulation times. These encouraging results suggest that further enhancement of these structures may yield candidates suitable for consideration as new therapeutics for the treatment of malaria. In combination these studies also provide strong support for the validity of targeting the Plasmodium glycolytic pathway and, in particular, LDH in the search for novel anti-malarials