Bi-Directional Relativistic Jets of the Radio Galaxy 1946+708: Constraints on the Hubble Constant

We present measurements of bi-directional motions in the jets of the radio galaxy 1946+708 at z=0.101. This is a Compact Symmetric Object with striking S-symmetry. Sensitive 15 GHz observations reveal a compact component at the center of symmetry with a strongly inverted spectrum, that we identify as the core. From five 4.9 GHz observations spread over 4 years we have determined the velocities of four compact jet components. If simple kinematic models can be applied then the inclination of the source and the bulk jet velocity can be directly determined for any assumed value of the Hubble constant. Conversely, the measurements already place constraints on the Hubble constant, and we show how further observations of 1946+708 can yield an increasingly accurate determination of H_0.Comment: in press at ApJ Letters, 12 page LaTex document includes 5 postscript figure

Improving the capabilities and use of strategic decision making tools.

Recent research has shown that a substantial proportion of local authorities do not use models for strategy formulation or scheme design and appraisal. Models were perceived to be unable to reflect the range of policy instruments which local authorities now use; and were seen as too complex for local authority staff and stakeholders to use themselves. To overcome these issues the MARS model has been enhanced to provide a transparent and easy to use tool with a flight simulator front-end. This paper describes the model along with improvements to the representation of public transport by inclusion of quality and crowding factors and the incorporation of urban heavy rail

The incidence and risk factors for new onset atrial fibrillation in the PROSPER study

Aims Atrial fibrillation/flutter (AF) is the most common arrhythmia in older people. It associates with reduced exercise capacity, increased risk of stroke, and mortality. We aimed to determine retrospectively whether pravastatin reduces the incidence of AF and whether any electrocardiographic measures or clinical conditions might be risk factors for its development. Methods and results The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) was a randomized, double-blind controlled trial that recruited 5804 individuals aged 70-82 years with a history of, or risk factors for, vascular disease. A total of 2891 were allocated to pravastatin and 2913 to placebo; mean follow-up was 3.2 years. Electrocardiograms (ECGs), which were recorded at baseline, annually thereafter, and at run-out, were processed by computer and reviewed manually. In all, 264 of 2912 (9.1%) of the placebo group and 283 of 2888 (9.8%) of the pravastatin-treated group developed AF [hazard ratio 1.08 (0.92,1.28), P = 0.35)]. Multivariate analysis showed that PR and QTc intervals, age, left ventricular hypertrophy, and ST-T abnormalities were related to development of AF after adjustment for many variables including alcohol consumption, which itself was univariately predictive of developing AF. Previous myocardial infarction on the ECG was not a risk factor. A history of vascular disease was strongly linked with developing AF but not diabetes and hypertension. Conclusion Pravastatin does not reduce the incidence of AF in older people at risk of vascular disease, at least in the short-medium term. Risk factors for AF include older age, prolongation of PR or QTc intervals, left ventricular hypertrophy, and ST-T abnormalities on the EC

VLBA Polarization Observations of Markarian 421 After a Gamma-Ray High State

We present four high dynamic range, dual-circular polarization, Very Long Baseline Array (VLBA) observations at 22 GHz of Markarian 421, taken throughout the year following the source's unprecedented gamma-ray high state in early 2001. These four new VLBA observations are combined with data from our earlier 1999 paper and archival VLBA data-sets that have become available since 1999 to produce a combined 28 epoch VLBA data-set on Mrk 421 spanning the years 1994 to 2002. No new component associated with the 2001 flares was seen on the total intensity images, but the combined data-set allowed precise measurements of the apparent speeds of the existing components. The peak measured apparent speed was for component C5, which has an apparent speed of 0.1 +/- 0.02 c (H_0=71 km s^{-1} Mpc^{-1}, Omega_m=0.27, and Omega_Lambda=0.73). No counterjet is seen with a limit on the jet to counterjet brightness ratio J >~ 100. These observed VLBI properties of Markarian 421 are consistent with a jet with a bulk Lorentz factor of about 2 and an angle to the line-of-sight of about 1 degree, suggesting a jet that decelerates between the gamma-ray producing region and the parsec scale. The VLBI core and inner jet (component C7) have fractional polarizations of about 5%, and an electric vector position angle (EVPA) aligned with the jet axis. Component C5 (at 1.5 mas from the core) has a higher fractional polarization of about 15%, and an EVPA nearly orthogonal to the jet axis. Significant variability is detected in the EVPA of component C6, which at two of the four epochs shows an EVPA aligned with the jet axis, possibly a sign of propagating disturbances that are only visible on the polarization images. If these propagating disturbances are linked to the 2001 gamma-ray high state, then their inferred apparent speed is between 1 and 3 c.Comment: 11 pages, accepted to Ap

Morphology of passivating organic ligands around a nanocrystal

Semiconductor nanocrystals are a promising class of materials for a variety of novel optoelectronic devices, since many of their properties, such as the electronic gap and conductivity, can be controlled. Much of this control is achieved via the organic ligand shell, through control of the size of the nanocrystal and the distance to other objects. We here simulate ligand-coated CdSe nanocrystals using atomistic molecular dynamics, allowing for the resolution of novel structural details about the ligand shell. We show that the ligands on the surface can lie flat to form a highly anisotropic 'wet hair' layer as opposed to the 'spiky ball' appearance typically considered. We discuss how this can give rise to a dot-to-dot packing distance of one ligand length since the thickness of the ligand shell is reduced to approximately one-half of the ligand length for the system sizes considered here; these distances imply that energy and charge transfer rates between dots and nearby objects will be enhanced due to the thinner than expected ligand shell. Our model predicts a non-linear scaling of ligand shell thickness as the ligands transition from 'spiky' to 'wet hair'. We verify this scaling using TEM on a PbS nanoarray, confirming that this theory gives a qualitatively correct picture of the ligand shell thickness of colloidal quantum dots.Comment: 17 Pages, 9 Figure

The two sided parsec scale structure of the Low Luminosity Active Galactic Nucleus in NGC 4278

We present new Very Long Baseline Interferometry observations of the LINER galaxy NGC 4278. The observations were taken with the Very Long Baseline Array (VLBA) and a single antenna of the Very Large Array (VLA) at 5 GHz and 8.4 GHz and have a linear resolution of <0.1 pc. Our radio data reveal a two sided structure, with symmetric S-shaped jets emerging from a flat spectrum core. We fit the jet brightness with gaussian components, which we identify from a previous observation taken five years before. By comparing the positions of the components in the two epochs, we measure motions between 0.45 +/- 0.14 and 3.76 +/- 0.65 mas, corresponding to apparent velocities < 0.2c, and to ages in the range 8.3 - 65.8 years. Assuming that the radio morphology is intrinsically symmetric and its appearance is governed by Doppler beaming effects, we find that NGC4278 has mildly relativistic jets (beta ~ 0.75), closely aligned to the line-of-sight (2 degrees < theta < 4 degrees). Alternatively, the source could be oriented at a larger angle and asymmetries could be related to the jet interaction with the surrounding medium. We also present new simultaneous VLA observations between 1.4 and 43 GHz, and a 5 GHz light curve between 1972 and 2003. The radio spectrum can be fit by a relatively steep power-law (alpha = 0.54). We find significant variability at 5 GHz. All these arguments indicate that the radiation from NGC 4278 is emitted via the synchrotron process by relativistic particles accelerated by a supermassive black hole. Despite a much lower power, this is the same process that takes place in ordinary radio loud AGNs.Comment: 29 pages, 9 figures, ApJ accepte

Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study

The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64 years without prior myocardial infarction followed for an average of 4.9 years. We hypothesised prospectively (a) that baseline levels of haemorheological variables were related to baseline and incident CHD and to mortality; and (b) that reduction in lipoproteins by pravastatin would lower plasma and blood viscosity, a potential contributory mechanism to CHD events. We therefore studied plasma and blood viscosity, fibrinogen, haematocrit, and blood cell counts at baseline and 1 year. At baseline, plasma and blood viscosity were related to risk factors, CHD measures, and claudication. On univariate analysis, baseline levels of all rheological variables (except platelet count) were related to incident CHD; CHD mortality; and total mortality. On multivariate analysis including baseline CHD and risk factors, plasma and blood viscosity, haematocrit and white cell count each remained significantly associated with incident CHD; while fibrinogen remained an independent predictor of mortality (all p&lt;0.03). After one year, lipoprotein reduction by pravastatin was associated with significant reductions (about one quarter of a standard deviation) in plasma viscosity (mean difference 0.02 mPa.s, p&lt;0.001) and in blood viscosity (mean difference 0.06 mPa.s, p&lt;0.001), but was not associated with significant changes in other rheological variables. We therefore suggest that pravastatin therapy, which reduces elevated lipoproteins in hypercholesterolaemic men, may lower risks of CHD and mortality partly by lowering plasma and blood viscosity. Further studies are required to test this hypothesis

Choosing treatment for localised prostate cancer: A patient-conducted-interview study

Objectives: Treatment choice can be particularly difficult in localised prostate cancer because of the uncertainty involved. Indeed, some men prefer maintaining their masculine identity and quality of life to potentially securing longer-term survival through surgery or radiotherapy. UK health services are now obliged to leave the choice of treatment to the patient and the aim of this study is to improve understanding of patients’ experiences of choosing treatment. Methods: A one-day participative workshop where men of six months post-diagnosis design and conduct audio and video interviews on each other about their experiences of choosing treatment. Results: The findings show that treatment choice is a complex process combining emotional and rational elements. Information gathering and delegation to professional expertise were two key themes that emerged. Conclusions: The findings emphasise that treatment choice for localised prostate cancer is little like the traditional notions of consumerism from which it is derived. Importantly, the results illustrate, from a patient perspective, how health professionals can engage in their roles as information providers and as experts

Storyline description of Southern Hemisphere midlatitude circulation and precipitation response to greenhouse gas forcing

As evidence of climate change strengthens, knowledge of its regional implications becomes an urgent need for decision making. Current understanding of regional precipitation changes is substantially limited by our understanding of the atmospheric circulation response to climate change, which to a high degree remains uncertain. This uncertainty is reflected in the wide spread in atmospheric circulation changes projected in multimodel ensembles, which cannot be directly interpreted in a probabilistic sense. The uncertainty can instead be represented by studying a discrete set of physically plausible storylines of atmospheric circulation changes. By mining CMIP5 model output, here we take this broader perspective and develop storylines for Southern Hemisphere (SH) midlatitude circulation changes, conditioned on the degree of global-mean warming, based on the climate responses of two remote drivers: the enhanced warming of the tropical upper troposphere and the strengthening of the stratospheric polar vortex. For the three continental domains in the SH, we analyse the precipitation changes under each storyline. To allow comparison with previous studies, we also link both circulation and precipitation changes with those of the Southern Annular Mode. Our results show that the response to tropical warming leads to a strengthening of the midlatitude westerly winds, whilst the response to a delayed breakdown (for DJF) or strengthening (for JJA) of the stratospheric vortex leads to a poleward shift of the westerly winds and the storm tracks. However, the circulation response is not zonally symmetric and the regional precipitation storylines for South America, South Africa, South Australia and New Zealand exhibit quite specific dependencies on the two remote drivers, which are not well represented by changes in the Southern Annular Mode