Equatorial Ionosphere Bottom-type Spread-F Observed by OI 630.0 nm Airglow Imaging

Bottom‐type spread F events were observed in the south American equatorial region by a VHF coherent radar and an ionosonde at São Luís (2.5°S, 44.3°W), an ionosonde at Fortaleza (3.9°S, 38.4° W) and an airglow OI 630.0 nm imager at Cariri (7.4°S, 36.5°W) and Brasilia (14.8°S, 47.6°W). In the evening of September 30, 2005, a long duration (∼70 minutes) bottom side scattering layer, confined in a narrow height region, was observed. At the same time all‐sky imager observed sinusoidal intensity depletions in the zonal plane extending more than 1500 km and elongated along the magnetic meridian. No strong spread F structures developed during the period. Subsequently well developed plasma bubbles were observed. This suggests that the observed bottom‐type spread F is an initial phase of the plasma bubbles. We report, for the first time, longitudinal and latitudinal extension of the bottom‐type spread F as diagnosed by optical imagers. Citation: Takahashi, H., et al. (2010), Equatorial ionosphere bottom‐type spread F observed by OI 630.0 nm airglow imaging

Overview and Summary of the Spread F Experiment (SpreadFex)

We provide here an overview of, and a summary of results arising from, an extensive experimental campaign (the Spread F Experiment, or SpreadFEx) performed from September to November 2005, with primary measurements in Brazil. The motivation was to define the potential role of neutral atmosphere dynamics, specifically gravity wave motions propagating upward from the lower atmosphere, in seeding Rayleigh-Taylor instability (RTI) and plasma bubbles extending to higher altitudes. Campaign measurements focused on the Brazilian sector and included ground-based optical, radar, digisonde, and GPS measurements at a number of fixed and temporary sites. Related data on convection and plasma bubble structures were also collected by GOES 12, and the GUVI instrument aboard the TIMED satellite

Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review. A total of 44 globally representative group members met in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents

Relationship between ionospheric plasma bubble occurrence and lightning strikes over the Amazon region

The vertical coupling between the troposphere and the ionosphere presents some remarkable features. Under intense tropospheric convection, gravity waves may be generated, and once they reach the ionosphere, these waves may seed instabilities and spread F and equatorial plasma bubble events may take place. Additionally, there is a close association between severe tropospheric convection and lightning strikes. In this work an investigation covering an equinox period (September–October) during the deep solar minimum (2009) presents the relation between lightning strike activity and spread F (equatorial plasma bubble) detected over a low-latitude Brazilian region. The results show a considerable correlation between these two phenomena. The common element in the center of this conformity seems to be the gravity waves. Once gravity waves and lightning strikes share the same source (intense tropospheric convection) and the effects of such gravity waves in the ionosphere include the seeding of instabilities according to the gravity waves magnitude, the monitoring of the lightning strike activity seems to offer some information about the subsequent development of spread F over the equatorial region

Cross-Linking Bi2S3 Ultrathin Nanowires: A Platform for Nanostructure Formation and Biomolecule Detection

This paper describes the use of chemical cross-linking of ultrathin inorganic nanowires; as a bottom-up strategy for nanostructure fabrication as well as a chemical detection platform. Nanowire microfibers are produced by spinning a nanowire dispersion into a cross-linker solution at room temperature. Nanomembranes with thicknesses down to 50 nm were obtained by injecting the nanowire dispersion at the crosslinker-solution/air interface. Furthermore, the sensitivity of the nanowire to amine cross-linkers allowed development of a novel sensing platform for small molecules, like the neurotransmitter serotonin, with detection limits in the picomolar regime