NAUCLEFOLININE: A NEW ALKALOID FROM THE ROOTS OF NAUCLEA LATIFOLIA

ABSTRACT. A novel indole alkaloid, nauclefolinine (1) and five known triterpenic compounds, rotundic acid (2), α-L-rhamnoquinovic acid (3), 3-O-β-D-glucopyranosyl-β-sitosterol (4), squalene (5) and sitosterol-3-O-6'-stearoyl-β-D-glucopyranoside (6) have been isolated from the roots of Nauclea latifolia

4,5-Epoxide-1,6-dimethyl-1-vinylhexyl p-coumarate: A novel monoterpene derivative from Cleistopholis patens

A novel monoterpene derivative (1) and four known partially and total acetylated tri- and tetrarhamonoside dodecanyl ether derivatives: cleistrioside-2 (2) and cleistrioside-3 (3), cleistetroside-6 (4) and cleistetroside peracetate (5) have been isolated from the fruits of Cleistopholis patens

Limonoids from <i>Carapa grandiflora</i> (Meliaceae)

Eight limonoids, carapolides C 2, D 3, E 4, F 5, G 6, H 7 and I 8 and evodoulone 13 have been isolated from the extracts of the seeds of Carapa grandiflora (Meliaceae). Compounds 2, 3 and 4 are new C-9, C-10 cleaved tetranortriterpenoids while 5 and 6 are novel tetranortriterpenoid spirolactones. Finally, carapolides H 7 and I 8 are new ring A cleaved derivatives with an intact ring D. All their structures were determined from spectroscopic data and chemical correlations

Trypanocidal diarylheptanoids from Aframomum letestuianum K. Schum (Zingiberaceae).

Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC50 values in the range of 1-3 g/mL were found for compounds 3 and 5

The structures of vepridimerines A-D, four new dimeric prenylated quinolone alkaloids from <i>Vepris louisii</i> and <i>Oricia renieri</i> (Rutaceae)

Four new isomeric dimeric prenylated quinolone alkaloids, vepridimerines A-D, have been isolated from the bark of Vepris louisii and Oricia renieri (Rutaceae) and have been assigned structures (2)–(5) respectively on the basis of spectroscopic evidence, in particular 1H and 13C n.m.r. data