Drivers of success in implementing sustainable tourism policies in urban areas

The existing literature in the field of sustainable tourism highlights a number of barriers that impede the implementation of policies in this area. Yet, not many studies have so far considered the factors that would contribute to putting this concept into practice, and few address the case of urban areas. The concept of sustainability has only received limited attention in urban tourism research, even though large cities are recognised as one of the most important tourist destinations that attract vast numbers of visitors. Adopting a case study approach, this paper discusses a number of drivers of success identified by policy-makers in London to contribute to the implementation of sustainable tourisms policies at the local level, and briefly looks at the relationship between these drivers and the constraints perceived by the respondents to hinder the implementation of such policies in practice. These findings may help policy-makers in other large cities to successfully develop and implement policies towards sustainable development of tourism in their area

Elastic scattering with weakly bound projectiles

Possible effects of the break-up channel on the elastic scattering threshold anomaly has been investigated. We used the weakly bound 6,7Li nuclei, which is known to undergo break-up, as projectiles in order to study the elastic scattering on a 27Al target. In this contribution we present preliminary results of these experiments, which were analyzed in terms of the Optical Model and compared with other elastic scattering data using weakly bound nuclei as projectile. © 2007 American Institute of Physics.Fil:Figueira, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Fernández Niello, J.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Arazi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Capurro, O.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Martí, G.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Pacheco, A.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina

Identification of the Bovine Arachnomelia Mutation by Massively Parallel Sequencing Implicates Sulfite Oxidase (SUOX) in Bone Development

Arachnomelia is a monogenic recessive defect of skeletal development in cattle. The causative mutation was previously mapped to a ∼7 Mb interval on chromosome 5. Here we show that array-based sequence capture and massively parallel sequencing technology, combined with the typical family structure in livestock populations, facilitates the identification of the causative mutation. We re-sequenced the entire critical interval in a healthy partially inbred cow carrying one copy of the critical chromosome segment in its ancestral state and one copy of the same segment with the arachnomelia mutation, and we detected a single heterozygous position. The genetic makeup of several partially inbred cattle provides extremely strong support for the causality of this mutation. The mutation represents a single base insertion leading to a premature stop codon in the coding sequence of the SUOX gene and is perfectly associated with the arachnomelia phenotype. Our findings suggest an important role for sulfite oxidase in bone development

Comprehensive study of reaction mechanisms for the Be9+Sm144 system at near- and sub-barrier energies

The delayed x-ray detection technique was used to measure complete and incomplete fusion cross sections for the $^{9}\mathrm{Be}+^{144}\mathrm{Sm}$ reaction at sub- and near-barrier energies. Elastic and inelastic scattering for this system were also measured. Reaction cross sections were derived and the transfer cross sections of one neutron were calculated. The suppression of complete fusion above the barrier, of the order of 10%, is attributed to $^{9}\mathrm{Be}$ breakup and is considerably smaller than the value of 30% found for the $^{9}\mathrm{Be}+^{208}\mathrm{Pb}$ system

Bootstrap method for constructing covariance matrices of optical-model parameters in the study of the threshold anomaly

The parameters of optical-model potentials are usually obtained by adjusting theoretical calculations to the corresponding experimental elastic-scattering data. It has been observed that the use of conventional covariance matrices for the evaluation of the uncertainties of the parameters obtained in this way, leads in general to unrealistically small values. This underestimate may be caused by either, an incorrect use of the statistical recipes, or by the lack of a systematic study of the robustness of the uncertainty values against the inclusion or exclusion of experimental data points within a given data set. In the present contribution we explore both factors. Regarding the first aspect we use a re-normalization for χ2, similar to the one proposed by R.T. Birge. In the second case we use the Bootstrap method to create synthetic sets based on all the available experimental data in order to derive an effective covariance matrix. These procedures were applied to the re-analysis of elastic-scattering data for several heavy-ion systems at energies close to the Coulomb barrie

Effect of the break-up on the fusion and elastic scattering of weakly bound projectiles on 64^{64}Zn

We study the behavior of the fusion, break-up, reaction and elastic scattering of different projectiles on $^{64}$Zn, at near and above barrier energies. We present fusion and elastic scattering data with the tightly bound $^{16}$O and the stable weakly bound $^{6}$Li, $^{7}$Li and $^{9}$Be projectiles. The data were analyzed by coupled channel calculations. The total fusion cross sections for these systems are not affected by the break-up process at energies above the barrier. The elastic (non-capture) break-up cross section is important at energies close and above the Coulomb barrier and increases the reaction cross sections. In addition we also show that the break-up process at near and sub-barrier energies is responsible for the vanishing of the usual threshold anomaly of the optical potential and give rise to a new type of anomaly.Comment: 24 pages, 10 figure

Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

Venetoclax (VEN) and hypomethylating agent (HMAs) regimens are emerging as the standard of care for unfit for chemotherapy acute myeloid leukemia (AML) patients, but the safety and feasibility of a total outpatient management have not been fully investigated. Fifty-nine AML patients with active disease received VEN and HMAs. Nineteen out of 59 (32.2%) patients received the first cycle as inpatients, whereas 40/59 (67.8%) patients were treated in the outpatient setting. No significant differences were observed with regard to incidence of adverse events (AEs), including tumor lysis syndrome (TLS), and the 30-day and 60-day mortality was comparable. Notably, an infectious prophylaxis inspired to that adopted during intensive chemotherapy resulted in a low infection rate with a reduced bacterial infections incidence in out- versus hospitalized patients (p <.0001). The overall time of hospitalization was significantly shorter in patients who received a total outpatient treatment as compared to those who received the first cycle as inpatients (5.9 vs. 39.7 days, p <.0001). Despite the adopted differences in treatment management, the efficacy was similar. These data indicate that a total outpatient management of VEN and HMAs is feasible in AML patients without negatively impacting on treatment efficacy and may yield pharmacoeconomic and quality-of-life benefits

Clinical and molecular characterization of diffuse large B-cell lymphomas with 13q14.3 deletion

Background: Deletions at 13q14.3 are common in chronic lymphocytic leukemia and are also present in diffuse large B-cell lymphomas (DLBCL) but never in immunodeficiency-related DLBCL. To characterize DLBCL with 13q14.3 deletions, we combined genome-wide DNA profiling, gene expression and clinical data in a large DLBCL series treated with rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone repeated every 21 days (R-CHOP21). Patients and methods: Affymetrix GeneChip Human Mapping 250K NspI and U133 plus 2.0 gene were used. MicroRNA (miRNA) expression was studied were by real-time PCR. Median follow-up of patients was 4.9 years. Results: Deletions at 13q14.3, comprising DLEU2/MIR15A/MIR16, occurred in 22/166 (13%) cases. The deletion was wider, including also RB1, in 19/22 cases. Samples with del(13q14.3) had concomitant specific aberrations. No reduced MIR15A/MIR16 expression was observed, but 172 transcripts were significantly differential expressed. Among the deregulated genes, there were RB1 and FAS, both commonly deleted at genomic level. No differences in outcome were observed in patients treated with R-CHOP21. Conclusions: Cases with 13q14.3 deletions appear as group of DLBCL characterized by common genetic and biologic features. Deletions at 13q14.3 might contribute to DLBCL pathogenesis by two mechanisms: deregulating the cell cycle control mainly due RB1 loss and contributing to immune escape, due to FAS down-regulatio

Real life use of prostacyclin analog (Iloprost), a multi-centric survey data from the scleroderma study group Emilia Romagna (Sclero-RER) and review of the literature

Background and aim: Iloprost is recommend worldwide for the treatment of RP and the healing of DUs. The aim of this study is to report the regimens of Iloprost administered in different rheumatological centers within the same regional Health System Methods: A questionnaire exploring different items related to the use of Iloprost was developed and reviewed by three expert rheumatologists. The questionnaire was distributed as an online survey to all local SSc referral centers in Emilia-Romagna (Italy). Data are reported as percentage or median with interquartile range (IQR), as appropriate. An updated review of world literature on this topic was also carried out. Results: All the invited centers completed the survey. There were both local (8) and university hospitals (4). The majority (58%) had a rheumatologist as head physician. All centers used Iloprost: a single monthly administration was the most common treatment (75%). The cycle lasted 1 [IQR 1-2] days with a 0.5-2.0 ng/Kg/min dose according to the drug tolerance of the patients. There were overall 68 spots (beds, reclining armchair, or simple armchair); 2.0 [1.5-4.0] patients were able to receive Iloprost at the same time. University Hospitals had more physicians at their disposal than local hospitals but less paramedic personnel (respectively: 1.8 vs 1.2 physicians, 1.5 vs 2.1 nurses). Conclusions: These observations were in line with the majority of previous studies reporting different regimens, comparing similar (but not identical) dose and schedule administration, however, despite differences being at times substantial, no standard infusion method is yet available. (www.actabiomedica.it)

IMPACTO DA “MÃE DE LEITE ELETRÔNICA” NO DESEMPENHO ZOOTÉCNICO DE LEITÕES LACTENTES

Com os avanços da genética na suinocultura e a aplicação de tecnologias no manejo o número de leitões nascidos, por parto, tem aumentado significativamente. Por consequência, as leitegadas raramente são uniformes e muitos leitões apresentam baixo peso ao nascimento. Pesquisas indicam que a cada leitão extra na média de nascidos acarreta uma redução de 100g no peso ao nascimento, dobrando o número de leitões que nascem com peso abaixo de 800g. O aumento da taxa de mortalidades entre os leitões com baixo peso, ainda nos primeiros dias de vida, é algo comum. Logo, torna-se essencial o emprego de alternativas que contribuam tanto para a diminuição da mortalidade pré-desmame quanto para o alcance da uniformidade da leitegada. Com o intuito de melhorar esses índices foi avaliado a influência do equipamento “mãe de leite eletrônica” sobre o desempenho zootécnico de leitões no período entre o nascimento e o desmame. O equipamento foi cedido por colaboradores da Empresa STA, de Joinville/SC. Cada lote experimental contou com dois grupos: o controle (GC) e o tratamento (GT). No GC os leitões receberam apenas aleitamento natural, fornecido pela mãe. No GT os leitões foram submetidos ao regime de aleitamento misto (natural, fornecido pela mãe; e o artificial, fornecido pelo equipamento o leite de vaca). Foram avaliadas 6 leitegadas, duas por experimento. As fêmeas eram provenientes de matrizes híbridas Landrace x Large White, entre o 3º e 6º parto. Ao todo realizaram-se 3 procedimentos experimentais. O aleitamento propiciado pelo equipamento beneficiou todas as leitegadas do GT já nos três primeiros dias de vida. Muitos leitões que apresentaram dificuldades de amamentarem-seadequadamente na mãe, pela competição da leitegada pelos tetos, conseguiram sobreviver pela disponibilidade de leite oferecida artificialmente. Por ocasião do desmame, o peso médio e o número de leitões foram similares numericamente entre as 6 leitegadas avaliadas durante o período experimental. No entanto, no GT observou-se maior desuniformidade entre os leitões, uma vez que alguns animais ganharam peso mais rápido pelo acesso também ao leite artificial. Apesar de auxiliar na sobrevivência dos leitões, evitando maiores taxas de mortalidade pré-desmame, principalmente nos primeiros dias após o parto, não houve contribuição do equipamento sobre a uniformidade dos lotes. Concluímos que a “mãe de leite eletrônica” possibilitou não só o interesse como também a ingestão de leite artificial pelos leitões, de modo com que mais tetos ficassem disponíveis para outros leitões durante a mamada. Evidenciamos também que tanto leitões refugos como os mais fracos se beneficiaram do aleitamento misto, mantendo seu desenvolvimento de forma adequada até o desmame. Por fim, a equipe indica a utilização do equipamento, no mínimo, durante os 14 primeiros dias de vida dos leitões