Temporal album

Transient synchronization has been used as a mechanism of recognizing auditory patterns using integrate-and-fire neural networks. We first extend the mechanism to vision tasks and investigate the role of spike dependent learning. We show that such a temporal Hebbian learning rule significantly improves accuracy of detection. We demonstrate how multiple patterns can be identified by a single pattern selective neuron and how a temporal album can be constructed. This principle may lead to multidimensional memories, where the capacity per neuron is considerably increased with accurate detection of spike synchronization

Discovery of a supernova associated with GRB 031203: SMARTS Optical-Infrared Lightcurves from 0.2 to 92 days

Optical and infrared monitoring of the afterglow site of gamma-ray burst (GRB) 031203 has revealed a brightening source embedded in the host galaxy, which we attribute to the presence of a supernova (SN) related to the GRB ("SN 031203"). We present details of the discovery and evolution of SN 031203 from 0.2 to 92 days after the GRB, derived from SMARTS consortium photometry in I and J bands. A template type Ic lightcurve, constructed from SN 1998bw photometry, is consistent with the peak brightness of SN 031203 although the lightcurves are not identical. Differential astrometry reveals that the SN, and hence the GRB, occurred less than 300 h_71^-1 pc (3-sigma) from the apparent galaxy center. The peak of the supernova is brighter than the optical afterglow suggesting that this source is intermediate between a strong GRB and a supernova.Comment: 11 pages, 3 figures, submitted to ApJ Letter

Knowledge and Possession of Take Home Naloxone Kits Among Street-Involved Youth in a Canadian Setting

BACKGROUND: The distribution of take-home naloxone (THN) kits has been an important strategy in reducing overdose fatalities among people who use drugs. However, little is known about the use of THN among youth who are street-involved. The present study explores knowledge and possession of THN among street-involved youth in a Canadian setting

Fatal disseminated varicella zoster infection following zoster vaccination in an immunocompromised patient

A 79-year-old man with chronic lymphocytic leukaemia presented with fever and a widespread vesicular rash on 19 November 2014. The patient had not been under immunosuppressive regime for 6 months. He had received a shingles vaccine on 14th October and developed flu-like symptoms after 2 weeks. Intravenous antimicrobial therapy including aciclovir was started. He remained stable with no evidence of systemic involvement. On day 5, he developed respiratory and renal failure that required transfer to intensive care unit. Vesicle fluid, bronchoalveolar lavage and plasma were positive for varicella zoster virus by PCR. Slight clinical improvement allowed extubation on day 16. He subsequently deteriorated and died on day 25. Multiorgan failure was considered the immediate cause of death whereas disseminated varicella zoster infection was stated in the medical certificate as the other condition leading to this outcome. Varicella zoster Oka vaccine strain was detected in vesicle fluid, using PCR

Imaging X-ray, Optical, and Infrared Observations of the Transient Anomalous X-ray Pulsar XTE J1810-197

We report X-ray imaging, timing, and spectral studies of XTE J1810-197, a 5.54s pulsar discovered by Ibrahim et al. (2003) in recent RXTE observations. In a set of short exposures with the Chandra HRC camera we detect a strongly modulated signal (55+/-4% pulsed fraction) with the expected period located at (J2000) 18:09:51.08, -19:43:51.7, with a uncertainty radius of 0.6 arcsec (90% C.L.). Spectra obtained with XMM-Newton are well fitted by a two-component model that typically describes anomalous X-ray pulsars (AXPs), an absorbed blackbody plus power law with parameters kT = 0.67+/-0.01 keV, Gamma=3.7+/-0.2, N_H=(1.05+/-0.05)E22 cm^-2, and Fx(0.5-10 keV) = 3.98E-11 ergs/cm2/s. Alternatively, a 2T blackbody fit is just as acceptable. The location of CXOU J180951.1-194351 is consistent with a point source seen in archival Einstein, Rosat, & ASCA images, when its flux was nearly two orders-of-magnitude fainter, and from which no pulsations are found. The spectrum changed dramatically between the "quiescent" and "active" states, the former can be modeled as a softer blackbody. Using XMM timing data, we place an upper limit of 0.03 lt-s on any orbital motion in the period range 10m-8hr. Optical and infrared images obtained on the SMARTS 1.3m telescope at CTIO show no object in the Chandra error circle to limits V=22.5, I=21.3, J=18.9, & K=17.5. Together, these results argue that CXOU J180951.1-194351 is an isolated neutron star, one most similar to the transient AXP AX J1844.8-0256. Continuing study of XTE J1810-197 in various states of luminosity is important for understanding and possibly unifying a growing class of isolated, young neutron stars that are not powered by rotation.Comment: 12 pages, 7 figures, AAS LaTex, uses emulateapj5.sty. Updated to include additional archival data and a new HRC observation. To appear in The Astrophysical Journa

Reliability of environmental DNA surveys to detect pond occupancy by newts at a national scale

The distribution assessment and monitoring of species is key to reliable environmental impact assessments and conservation interventions. Considerable effort is directed towards survey and monitoring of great crested newts (Triturus cristatus) in England. Surveys are increasingly undertaken using indirect methodologies, such as environmental DNA (eDNA). We used a large data set to estimate national pond occupancy rate, as well as false negative and false positive error rates, for commercial eDNA protocols. Additionally, we explored a range of habitat, landscape and climatic variables as predictors of pond occupancy. In England, 20% of ponds were estimated to be occupied by great crested newts. Pond sample collection error rates were estimated as 5.2% false negative and 1.5% false positive. Laboratory error indicated a negligible false negative rate when 12 qPCR replicates were used. Laboratory false positive error was estimated at 2% per qPCR replicate and is therefore exaggerated by high levels of laboratory replication. Including simple habitat suitability variables into the model revealed the importance of fish, plants and shading as predictors of newt presence. However, variables traditionally considered as important for newt presence may need more precise and consistent measurement if they are to be employed as reliable predictors in modelling exercises

An RShiny app for modelling environmental DNA data: accounting for false positive and false negative observation error

Environmental DNA (eDNA) surveys have become a popular tool for assessing the distribution of species. However, it is known that false positive and false negative observation error can occur at both stages of eDNA surveys, namely the field sampling stage and laboratory analysis stage. We present an RShiny app that implements the Griffin et al. (2020) statistical method, which accounts for false positive and false negative errors in both stages of eDNA surveys that target single species using quantitative PCR methods. Following Griffin et al. (2020), we employ a Bayesian approach and perform efficient Bayesian variable selection to identify important predictors for the probability of species presence as well as the probabilities of observation error at either stage. We demonstrate the RShiny app using a data set on great crested newts collected by Natural England in 2018, and we identify water quality, pond area, fish presence, macrophyte cover and frequency of drying as important predictors for species presence at a site. The state-of-the-art statistical method that we have implemented is the only one that has specifically been developed for the purposes of modelling false negative and false positive observation error in eDNA data. Our RShiny app is user-friendly, requires no prior knowledge of R and fits the models very efficiently. Therefore, it should be part of the tool-kit of any researcher or practitioner who is collecting or analysing eDNA data