56 research outputs found
Cerebellar Zones: A Personal History
Cerebellar zones were there, of course, before anyone noticed them. Their history is that of young people, unhindered by preconceived ideas, who followed up their observations with available or new techniques. In the 1960s of the last century, the circumstances were fortunate because three groups, in Leiden, Lund, and Bristol, using different approaches, stumbled on the same zonal pattern in the cerebellum of the cat. In Leiden, the HΓ€ggqvist myelin stain divulged the compartments in the cerebellar white matter that channel the afferent and efferent connections of the zones. In Lund, the spino-olivocerebellar pathways activated from individual spinal funiculi revealed the zonal pattern. In Bristol, charting the axon reflex of olivocerebellar climbing fibers on the surface of the cerebellum resulted in a very similar zonal map. The history of the zones is one of accidents and purposeful pursuit. The technicians, librarians, animal caretakers, students, secretaries, and medical illustrators who made it possible remain unnamed, but their contributions certainly should be acknowledged
Purkinje cell input to cerebellar nuclei in tottering: Ultrastructure and physiology
Homozygous tottering mice are spontaneous ataxic mutants, which carry a mutation in the gene encoding the ion pore of the P/Q-type voltage-gated calcium channels. P/Q-type calcium channels are prominently expressed in Purkinje cell terminals, but it is unknown to what extent these inhibitory terminals in tottering mice are affected at the morphological and electrophysiological level. Here, we investigated the distribution and ultrastructure of their Purkinje cell terminals in the cerebellar nuclei as well as the activities of their target neurons. The densities of Purkinje cell terminals and their synapses were not significantly affected in the mutants. However, the Purkinje cell terminals were enlarged and had an increased number of vacuoles, whorled bodies, and mitochondria. These differences started to occur between 3 and 5 weeks of age and persisted throughout adulthood. Stimulation of Purkinje cells in adult tottering mice resulted in inhibition at normal latencies, but the activities of their postsynaptic neurons in the cerebellar nuclei were abnormal in that the frequency and irregularity of their spiking patterns were enhanced. Thus, although the number of their terminals and their synaptic contacts appear quantitatively intact, Purkinje cells in tottering mice show several signs of axonal damage that may contribute to altered postsynaptic activities in the cerebellar nuclei
Behavioural Significance of Cerebellar Modules
A key organisational feature of the cerebellum is its division into a series of cerebellar modules. Each module is defined by its climbing input originating from a well-defined region of the inferior olive, which targets one or more longitudinal zones of Purkinje cells within the cerebellar cortex. In turn, Purkinje cells within each zone project to specific regions of the cerebellar and vestibular nuclei. While much is known about the neuronal wiring of individual cerebellar modules, their behavioural significance remains poorly understood. Here, we briefly review some recent data on the functional role of three different cerebellar modules: the vermal A module, the paravermal C2 module and the lateral D2 module. The available evidence suggests that these modules have some differences in function: the A module is concerned with balance and the postural base for voluntary movements, the C2 module is concerned more with limb control and the D2 module is involved in predicting target motion in visually guided movements. However, these are not likely to be the only functions of these modules and the A and C2 modules are also both concerned with eye and head movements, suggesting that individual cerebellar modules do not necessarily have distinct functions in motor control
Fonction lutοΏ½otrophique de greffes hypophysaires transplantοΏ½es dans l'hypothalamus chez le rat
INFLUENCE DES HORMONES GONADOTROPES SUR LA DURΓE DES PROCESSUS SPERMATOGΓNΓTIQUES CHEZ LE RAT
International audienc
Pituitary-dependent renin-like immunoreactivity in the rat testis.
By means of a specific anti-rat renin antiserum, immunohistochemical staining was observed restricted to Leydig cells of rat testis. Specificity of the staining was ascertained by the absence of reaction with nonimmune serum or with the antiserum preincubated with rat renin. Specific staining of Leydig cells was absent in newborn rats; it developed with the onset of puberty. Staining was suppressed or abolished by hypophysectomy and estrogen treatment and was reduced by gonadotropin stimulation. Vasectomy destroyed the seminiferous epithelium but did not impair renin-like immunoreactivity of the interstitial tissue. It is concluded that Leydig cells contain a pituitary-dependent renin-like substance.Journal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Compared Localizations of Prolactin-Like and Adrenocorticotropin Immunoreactivities within the Brain of the Rat
Effects of injection of 3-acetylpyridine on the levels of taurine in the cerebellum and medulla of the rat: A reappraisal
Levels of several amino acids in the cerebellar peduncles and four medullary nuclei of control and 3-acetylpyridine-treated rats
- β¦