The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes.

Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo. ACF generates and maintains nucleosome spacing by constantly moving a nucleosome towards the longer flanking DNA faster than the shorter flanking DNA. How the enzyme rapidly moves back and forth between both sides of a nucleosome to accomplish bidirectional movement is unknown. Here we show that nucleosome movement depends cooperatively on two ACF molecules, indicating that ACF functions as a dimer of ATPases. Further, the nucleotide state determines whether the dimer closely engages one or both sides of the nucleosome. Three-dimensional reconstruction by single-particle electron microscopy of the ATPase-nucleosome complex in an activated ATP state reveals a dimer architecture in which the two ATPases face each other. Our results indicate a model in which the two ATPases work in a coordinated manner, taking turns to engage either side of a nucleosome, thereby allowing processive bidirectional movement. This novel dimeric motor mechanism differs from that of dimeric motors such as kinesin and dimeric helicases that processively translocate unidirectionally and reflects the unique challenges faced by motors that move nucleosomes

A Conformal Mapping and Isothermal Perfect Fluid Model

Instead of conformal to flat spacetime, we take the metric conformal to a spacetime which can be thought of as ``minimally'' curved in the sense that free particles experience no gravitational force yet it has non-zero curvature. The base spacetime can be written in the Kerr-Schild form in spherical polar coordinates. The conformal metric then admits the unique three parameter family of perfect fluid solution which is static and inhomogeneous. The density and pressure fall off in the curvature radial coordinates as $R^{-2},$ for unbounded cosmological model with a barotropic equation of state. This is the characteristic of isothermal fluid. We thus have an ansatz for isothermal perfect fluid model. The solution can also represent bounded fluid spheres.Comment: 10 pages, TeX versio

Modeling Repulsive Gravity with Creation

There is a growing interest in the cosmologists for theories with negative energy scalar fields and creation, in order to model a repulsive gravity. The classical steady state cosmology proposed by Bondi, Gold and Hoyle in 1948, was the first such theory which used a negative kinetic energy creation field to invoke creation of matter. We emphasize that creation plays very crucial role in cosmology and provides a natural explanation to the various explosive phenomena occurring in local (z<0.1) and extra galactic universe. We exemplify this point of view by considering the resurrected version of this theory - the quasi-steady state theory, which tries to relate creation events directly to the large scale dynamics of the universe and supplies more natural explanations of the observed phenomena. Although the theory predicts a decelerating universe at the present era, it explains successfully the recent SNe Ia observations (which require an accelerating universe in the standard cosmology), as we show in this paper by performing a Bayesian analysis of the data.Comment: The paper uses an old SNeIa dataset. With the new improved data, for example the updated gold sample (Riess et al, astro-ph/0611572), the fit improves considerably (\chi^2/DoF=197/180 and a probability of goodness-of-fit=18%

Progress towards the vindication of panspermia

Theories of panspermia are rapidly coming into vogue, with the possibility of the transfer of viable bacterial cells from one planetary abode to another being generally accepted as inevitable. The panspermia models of Hoyle and Wickramasinghe require the transfer of viable bacterial cells from interstellar dust to comets and back into interplanetary and interstellar space. In such a cycle a viable fraction of as little as 10−18 at the inception of a newly formed comet/planet system suffices for cometary panspermia to dominate over competing processes for the origin and transfer of life. The well-attested survival attributes of microbes under extreme conditions, which have recently been discovered, gives credence to the panspermia hypothesis. The prediction of the theory that comets bring microbes onto the Earth at the present time is testable if aseptic collections of stratospheric air above the tropopause can be obtained. We describe a recent collection of this kind and report microbiological analysis that shows the existence of viable cells at 41 km, falling to Earth at the rate of a few tonnes per day over the entire globe. Some of these cells have been cultured in the laboratory and found to include microorganisms that are not too different from related species on the Earth. This is in fact what the Hoyle-Wickramasinghe theory predicts. The weight of evidence goes against the more conservative explanation that organisms are being lofted to the high atmosphere from the ground

Star formation rate density and the stochastic background of gravitational waves

There is in the literature a number of papers addressing the stochastic background of gravitational waves (GWs) generated by an ensemble of astrophysical sources. The main ingredient in such studies is the so called star formation rate density (SFRD), which gives the density of stars formed per unit time. Some authors argue, however, that there is, in the equation that determines the amplitude of the stochastic background of GWs, an additional (1+z) term dividing the SFRD, which would account for the effect of cosmic expansion onto the time variable. We argue here that the inclusion of this additional term is wrong. In order to clarify where the inclusion of the (1+z) term is really necessary, we briefly discuss the calculation of event rates in the study of GRBs (gamma ray bursts) from cosmological origin.Comment: 4 page

On the stability of general relativistic geometric thin disks

The stability of general relativistic thin disks is investigated under a general first order perturbation of the energy momentum tensor. In particular, we consider temporal, radial and azimuthal "test matter" perturbations of the quantities involved on the plane $z=0$. We study the thin disks generated by applying the "displace, cut and reflect" method, usually known as the image method, to the Schwarzschild metric in isotropic coordinates and to the Chazy-Curzon metric and the Zipoy-Voorhees metric ($\gamma$-metric) in Weyl coordinates. In the case of the isotropic Schwarzschild thin disk, where a radial pressure is present to support the gravitational attraction, the disk is stable and the perturbation favors the formation of rings. Also, we found the expected result that the thin disk models generated by the Chazy-Curzon and Zipoy-Voorhees metric with only azimuthal pressure are not stable under a general first order perturbationComment: 11 pages, RevTex. Phys Rev D (in press

Gravitational and electromagnetic fields of a charged tachyon

An axially symmetric exact solution of the Einstein-Maxwell equations is obtained and is interpreted to give the gravitational and electromagnetic fields of a charged tachyon. Switching off the charge parameter yields the solution for the uncharged tachyon which was earlier obtained by Vaidya. The null surfaces for the charged tachyon are discussed.Comment: 8 pages, LaTex, To appear in Pramana- J. Physic

On the Perturbative Solutions of Bohmian Quantum Gravity

In this paper we have solved the Bohmian equations of quantum gravity, perturbatively. Solutions up to second order are derived explicitly, but in principle the method can be used in any order. Some consequences of the solution are disscused.Comment: 14 Pages, RevTeX. To appear in Phys. Rev.

R+R2R + R^2 Gravity as R+R + Backreaction

Quadratic theory of gravity is a complicated constraint system. We investigate some consequences of treating quadratic terms perturbatively (higher derivative version of backreaction effects). This approach is shown to overcome some well known problems associated with higher derivative theories, i.e., the physical gravitational degree of freedom remains unchanged from those of Einstein gravity. Using such an interpretation of $R + \beta R^2$ gravity, we investigate a classical and Wheeler DeWitt evolution of $R + \beta R^2$ gravity for a particular sign of $\beta$, corresponding to non- tachyon case. Matter is described by a phenomenological $\rho \propto a(t)^{-n}$. It is concluded that both the Friedmann potential $U(a)$ (${\dot a}^2 + 2U(a) = 0$) and the Wheeler DeWitt potential $W(a)$ ($\left[-{\partial^2\over \partial a^2} + 2W(a)\right]\psi (a) =0$) develop repulsive barriers near $a\approx 0$ for $n>4$ (i.e., $p > {1\over 3}\rho$). The interpretations is clear. Repulsive barrier in $U(a)$ implies that a contracting FRW universe ($k>0, k=0, k<0$) will bounce to an expansion phase without a total gravitational collapse. Repulsive barrier in $W(a)$ means that $a \approx 0$ is a classically forbidden region. Therefore, probability of finding a universe with the big bang singularity ($a=0$ ) is exponentially suppressed.Comment: Accepted for publication in Phy. Rev. D.,18 pages, 6 figures, Latex fil

A Machian Model of Dark Energy

Einstein believed that Mach's principle should play a major role in finding a meaningful spacetime geometry, though it was discovered later that his field equations gave some solutions which were not Machian. It is shown, in this essay, that the kinematical $\Lambda$ models, which are invoked to solve the cosmological constant problem, are in fact consistent with Mach's ideas. One particular model in this category is described which results from the microstructure of spacetime and seems to explain the current observations successfully and also has some benefits over the conventional models. This forces one to think whether the Mach's ideas and the cosmological constant are interrelated in some way.Comment: Received an Honorable mention in the Essay Contest-2002 sponsored by the Gravity Research Foundation; A paragraph added on how the model can explain the CMB anisotropy observations; To appear in the Classical and Quantum Gravit