449 research outputs found
Nickel-Catalyzed CarbonâCarbon Bond-Forming Reactions of Unactivated Tertiary Alkyl Halides: Suzuki Arylations
The first Suzuki cross-couplings of unactivated tertiary alkyl electrophiles are described. The method employs a readily accessible catalyst (NiBr[subscript 2]¡diglyme/4,4â˛-di-tert-butyl-2,2â˛-bipyridine, both commercially available) and represents the initial example of the use of a group 10 catalyst to cross-couple unactivated tertiary electrophiles to form CâC bonds. This approach to the synthesis of all-carbon quaternary carbon centers does not suffer from isomerization of the alkyl group, in contrast with the umpolung strategy for this bond construction (cross-coupling of a tertiary alkylmetal with an aryl electrophile). Preliminary mechanistic studies are consistent with the generation of a radical intermediate along the reaction pathway.National Institute of General Medical Sciences (U.S.) (R01-GM62871)Merck Research Laboratories (Summer Fellowship
F. Bryk. Parnassius Apollo L. und sein Formenkreis
Volume: 63Start Page: 184End Page: 18
Zur Kenntnis des Kopfbaues der Dipterenlarven und -imagines
Volume: 46Start Page: 241End Page: 25
Tweede supplement op de Nieuwe Naamlijst van Nederlandsche Diptera
Volume: 59Start Page: 293End Page: 32
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