Study of local anesthetics. Part* 166:Conductometric determination of the critical micelle concentration of local anesthetic heptacainium chloride in aqueous electrolvte solution

Specific conductivities of local anesthetic heptacainium chloride XlX (HCC XlX) (N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidinium chloride), in aqueous electrolyte solution (0.05 mol.1−1 NaCl) were measured as a function of the concentration and temperature. The critical micelle concentrations (c.m.c) and the counterion (β) binding of the micelles were estimated from the dependence of the specific conductivity of the substrate concentration. The temperature dependence of ln c.m.c was fitted to the function of the second degree polynomial. From the fitting parameters, Gibss free energies (ΔG0), enthalpies (ΔH0), and entropies (ΔS0) of micellization as a function of temperature were estimated. The "mass action model" was applied to micelle formation to calculate the micellization parameters

Influence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids

A series of 14 hydrochlorides of piperidinylethyl esters of orthosubstituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobactenum kansasii and Mycobactenum avium. In vitro antimycobacterial activrty becomes higher with increasing hydrophobicity of the substituents. The alkoxy group is not necessary in order for the basic ethyl esters of phenylcarbamic acids to display antimycobacterial activity

Study of Local Anesthetics. Part* 168 Critical Micelle Concentration of Alkyloxy Homoloqs of Local Anesthetic Heptacainium Chloride Determined by Ion Sensitive Electrode

The critical micelle concentrations (c.m.c.) of alkyloxy homologs of local anesthetic N-[2-(2-alkyloxyphenylcarbamolyoxy)-ethyl]-piperidinium chloride (CnA) with n=3, 5, 7, 8, 10 and 12 carbons in alkyloxy substituent determined by surfactant ion sensitive electrode (ISE) depend exponentially on n: lnc.m.c.=0.70+0.49n and lnc.m.c.=0.57+0.62n at t=25 °C and pH≈4.5 in water and 0.1 mol.l-1 NaCl solution, respectively, where the free energy of transfer of the alkyloxymethylene group from the aqueous phase into the micelle hydrophobic interior is ΔG0=(-0.49±0.008)RT in water and ΔG0=(-The critical micelle concentrations (c.m.c.) of alkyloxy homologs of local anesthetic N-[2-(2-alkyloxyphenylcarbamolyoxy)-ethyl]-piperidinium chloride (CnA) with n=3, 5, 7, 8, 10 and 12 carbons in alkyloxy substituent determined by surfactant ion sensitive electrode (ISE) depend exponentially on n: lnc.m.c.=0.70+0.49n and lnc.m.c.=0.57+0.62n at t=25 °C and pH≈4.5 in water and 0.1 mol.l-1 NaCl solution, respectively, where the free energy of transfer of the alkyloxymethylene group from the aqueous phase into the micelle hydrophobic interior is ΔG0=(-0.49±0.008)RT in water and ΔG0=(-0.62±0.06)RT in the 0.1 mol.l-1 NaCl solution. The enthalpic and entropic contributions to the standard Gibbs energy of micellization of heptacainium chloride (heptyloxy homologs of CnA) in 0.1 mol.l-1 NaCl solution were calculated according to the phase separation model in the temperature range of 25-45 °C.0.62±0.06)RT in the 0.1 mol.l-1 NaCl solution. The enthalpic and entropic contributions to the standard Gibbs energy of micellization of heptacainium chloride (heptyloxy homologs of CnA) in 0.1 mol.l-1 NaCl solution were calculated according to the phase separation model in the temperature range of 25-45 °C