Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy

This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled

Systematic study of the symmetry energy coefficient in finite nuclei

The symmetry energy coefficients in finite nuclei have been studied systematically with a covariant density functional theory (DFT) and compared with the values calculated using several available mass tables. Due to the contamination of shell effect, the nuclear symmetry energy coefficients extracted from the binding energies have large fluctuations around the nuclei with double magic numbers. The size of this contamination is shown to be smaller for the nuclei with larger isospin value. After subtracting the shell effect with the Strutinsky method, the obtained nuclear symmetry energy coefficients with different isospin values are shown to decrease smoothly with the mass number $A$ and are subsequently fitted to the relation $\dfrac{4a_{\rm sym}}{A}=\dfrac{b_v}{A}-\dfrac{b_s}{A^{4/3}}$. The resultant volume $b_v$ and surface $b_s$ coefficients from axially deformed covariant DFT calculations are $121.73$ and $197.98$ MeV respectively. The ratio $b_s/b_v=1.63$ is in good agreement with the value derived from the previous calculations with the non-relativistic Skyrme energy functionals. The coefficients $b_v$ and $b_s$ corresponding to several available mass tables are also extracted. It is shown that there is a strong linear correlation between the volume $b_v$ and surface $b_s$ coefficients and the ratios $b_s/b_v$ are in between $1.6-2.0$ for all the cases.Comment: 16 pages, 6 figure

Nonlinear Aggregation-Diffusion Equations: Radial Symmetry and Long Time Asymptotics

We analyze under which conditions equilibration between two competing effects, repulsion modeled by nonlinear diffusion and attraction modeled by nonlocal interaction, occurs. This balance leads to continuous compactly supported radially decreasing equilibrium configurations for all masses. All stationary states with suitable regularity are shown to be radially symmetric by means of continuous Steiner symmetrization techniques. Calculus of variations tools allow us to show the existence of global minimizers among these equilibria. Finally, in the particular case of Newtonian interaction in two dimensions they lead to uniqueness of equilibria for any given mass up to translation and to the convergence of solutions of the associated nonlinear aggregation-diffusion equations towards this unique equilibrium profile up to translations as $t\to\infty$

Enhanced collectivity in neutron-deficient Sn isotopes in energy functional based collective Hamiltonian

The low-lying collective states in Sn isotopes are studied by a five-dimensional collective Hamiltonian with parameters determined from the triaxial relativistic mean-field calculations using the PC-PK1 energy density functional. The systematics for both the excitation energies of $2^+_1$ states and $B(E2;0^+_1\to 2^+_1)$ values are reproduced rather well, in particular, the enhanced E2 transitions in the neutron-deficient Sn isotopes with N<66. We show that the gradual degeneracy of neutron levels 1g7/2 and 2d5/2 around the Fermi surface leads to the increase of level density and consequently the enhanced paring correlations from N=66 to 58. It provokes a large quadrupole shape fluctuation around the spherical shape, and leads to an enhanced collectivity in the isotopes around N=58.Comment: 5 pages, 4 figures, accepted for publication in Physics Letters