Analisis dan Perancangan Sistem Interactive Voice Response (IVR) Berbasis Openvxi Menggunakan Asterisk pada Hotel Sahid Jaya

The purpose of this study is to provide a deep understanding of technology of IVR (Interactive Voice Recognition) in OpenVXI based network using Asterisk, that help Sahid Jaya hotel to streamline communication with the guests, improving service and employee effectiveness. The methodology used is analysis which is through surveys, observation and interviews with the company and the design method by designing system from the existing needs analysis. The results obtained from this research is Communication System based in IVR OpenVXI can be applied to existing VoIP network, without disrupting the existing network. Some existing services can be supported with this system USAge. Conclusions can be drawn is the use of IVR in the network using VoIP technology is the best solution to overcome the problems and needs of the hospitality which one of these is limited information guest cna get that can provided by non-operators and for support service improvement

Demographic and Clinical Characteristics of Mucinous Epithelial Ovarian Cancer, and Survival Following a Mucinous Epithelial Ovarian Cancer Diagnosis

Alternative & renewable energy sources & technolog

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing cancer cell invasiveness, progression and tissue remodelling through an abundant secretion of exosomes, dictating cancer strategy to the whole host. A role of exosomes in driving melanoma progression under microenvironmental acidity was never described. Methods: We studied four differently staged human melanoma lines, reflecting melanoma progression, under microenvironmental acidic pHs pressure ranging between pH 6.0-6.7. To estimate exosome secretion as a function of tumor stage and environmental pH, we applied a technique to generate native fluorescent exosomes characterized by vesicles integrity, size, density, markers expression, and quantifiable by direct FACS analysis. Functional roles of exosomes were tested in migration and invasion tests. Then we performed a comparative proteomic analysis of acid versus control exosomes to elucidate a specific signature involved in melanoma progression. Results: We found that metastatic melanoma secretes a higher exosome amount than primary melanoma, and that acidic pH increases exosome secretion when melanoma is in an intermediate stage, i.e. metastatic non-invasive. We were thus able to show that acidic pH influences the intercellular cross-talk mediated by exosomes. In fact when exposed to exosomes produced in an acidic medium, pH naïve melanoma cells acquire migratory and invasive capacities likely due to transfer of metastatic exosomal proteins, favoring cell motility and angiogenesis. A Prognoscan-based meta-analysis study of proteins enriched in acidic exosomes, identified 11 genes (HRAS, GANAB, CFL2, HSP90B1, HSP90AB1, GSN, HSPA1L, NRAS, HSPA5, TIMP3, HYOU1), significantly correlating with poor prognosis, whose high expression was in part confirmed in bioptic samples of lymph node metastases. Conclusions: A crucial step of melanoma progression does occur at melanoma intermediate -stage, when extracellular acidic pH induces an abundant release and intra-tumoral uptake of exosomes. Such exosomes are endowed with pro-invasive molecules of clinical relevance, which may provide a signature of melanoma advancement

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

BACKGROUND:The glycolytic nature of malignant tumors contributes to high levels of extracellular acidity in the tumor microenvironment. Tumor acidity is a driving force in invasion and metastases. Recently, it has been shown that buffering of extracellular acidity through systemic administration of oral bicarbonate can inhibit the spread of metastases in a mouse model for metastatic breast cancer. While these findings are compelling, recent assessments into the use of oral bicarbonate as a cancer intervention reveal limitations.METHODS:We posited that safety and efficacy of bicarbonate could be enhanced by dichloroacetate (DCA), a drug that selectively targets tumor cells and reduces extracellular acidity through inhibition of glycolysis. Using our mouse model for metastatic breast cancer (MDA-MB-231), we designed an interventional survival study where tumor bearing mice received bicarbonate, DCA, or DCA-bicarbonate (DB) therapies chronically.RESULTS:Dichloroacetate alone or in combination with bicarbonate did not increase systemic alkalosis in mice. Survival was longest in mice administered bicarbonate-based therapies. Primary tumor re-occurrence after surgeries is associated with survival rates. Although DB therapy did not significantly enhance oral bicarbonate, we did observe reduced pulmonary lesion diameters in this cohort. The DCA monotherapy was not effective in reducing tumor size or metastases or improving survival time. We provide in vitro evidence to suggest this outcome may be a function of hypoxia in the tumor microenvironment.CONCLUSIONS:DB combination therapy did not appear to enhance the effect of chronic oral bicarbonate. The anti-tumor effect of DCA may be dependent on the cancer model. Our studies suggest DCA efficacy is unpredictable as a cancer therapy and further studies are necessary to determine the role of this agent in the tumor microenvironment.This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at [email protected]

Acidic Extracellular pH Promotes Activation of Integrin αvβ3

Acidic extracellular pH is characteristic of the cell microenvironment in several important physiological and pathological contexts. Although it is well established that acidic extracellular pH can have profound effects on processes such as cell adhesion and migration, the underlying molecular mechanisms are largely unknown. Integrin receptors physically connect cells to the extracellular matrix, and are thus likely to modulate cell responses to extracellular conditions. Here, we examine the role of acidic extracellular pH in regulating activation of integrin [alpha]v[beta]3. Through computational molecular dynamics simulations, we find that acidic extracellular pH promotes opening of the [alpha]v[beta]3 headpiece, indicating that acidic pH can thereby facilitate integrin activation. This prediction is consistent with our flow cytometry and atomic force microscope-mediated force spectroscopy assays of integrin [alpha]v[beta]3 on live cells, which both demonstrate that acidic pH promotes activation at the intact cell surface. Finally, quantification of cell morphology and migration measurements shows that acidic extracellular pH affects cell behavior in a manner that is consistent with increased integrin activation. Taken together, these computational and experimental results suggest a new and complementary mechanism of integrin activation regulation, with associated implications for cell adhesion and migration in regions of altered pH that are relevant to wound healing and cancer.National Institute of Biomedical Imaging and Bioengineering (U.S.) (Award Number T32EB006348)Massachusetts Institute of Technology (Collamore-Rogers Fellowship)National Institutes of Health (U.S.) (NIH Cell Migration Consortium Grant U54-GM069668)National Science Foundation (U.S.) (CAREER Award)Singapore-MIT Alliance for Research and Technology (BioSystem and Micromechanics (BioSyM) Interdisciplinary Research Group

Enhancing the sustainability performance of Agri-Food Supply Chains by implementing Industry 4.0

[EN] In order to enhance the sustainability in the supply chain, its members should define and pursue common objectives in the three dimensions of the sustainability (economic, environmental and social). The Agri-Food Supply Chain (AFSC) is a network of different members such as farmers (producers), processors and distributors (wholesales, retailers.), etc.. In order to achieve the performance objectives of the AFSC, Industry 4.0 technologies can be implemented. The aim of this paper is to present a classification of these technologies according to two criteria: objective to be achieved (environmental or social) specified in the main issues to be covered in each objective and member of the AFSC supply chain where it is implemented. In this work, we focus on technologies that deal with environmental and social sustainability because economic sustainability will depend on the specific characteristics of the business (a supply chain using a specific Industry 4.0 technology may be profitable while others do not).This work has been funded by the Project GV/2017/065 "Development of a decision support tool for the management and improvement of sustainability in supply chains" funded by the Regional Government of Valencia. Authors also acknowledge the Project 691249, RUC-APS: Enhancing and implementing Knowledge based ICT solutions within high Risk and Uncertain Conditions for Agriculture Production Systems.Pérez Perales, D.; Verdecho Sáez, MJ.; Alarcón Valero, F. (2019). Enhancing the sustainability performance of Agri-Food Supply Chains by implementing Industry 4.0. IFIP Advances in Information and Communication Technology. 568:496-503. https://doi.org/10.1007/978-3-030-28464-0_43S496503568Camarinha-Matos, L.M., Fornasiero, R., Afsarmanesh, H.: Collaborative networks as a core enabler of Industry 4.0. In: Camarinha-Matos, L.M., Afsarmanesh, H., Fornasiero, R. (eds.) PRO-VE 2017. IAICT, vol. 506, pp. 3–17. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-65151-4_1Stich, V., Gudergan, G., Zeller, V.: Need and solution to transform the manufacturing industry in the age of Industry 4.0 – a capability maturity index approach. In: Camarinha-Matos, L.M., Afsarmanesh, H., Rezgui, Y. (eds.) PRO-VE 2018. IAICT, vol. 534, pp. 33–42. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-99127-6_3Flores, M., Maklin, D., Golob, M., Al-Ashaab, A., Tucci, C.: Awareness towards Industry 4.0: key enablers and applications for internet of things and big data. In: Camarinha-Matos, L.M., Afsarmanesh, H., Rezgui, Y. (eds.) PRO-VE 2018. 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How Do Humans Control Physiological Strain during Strenuous Endurance Exercise?

Background: Methodology/principal Findings: Conclusions/significance: Distance running performance is a viable model of human locomotion.To evaluate the physiologic strain during competitions ranging from 5-100 km, we evaluated heart rate (HR) records of competitive runners (n = 211). We found evidence that: 1) physiologic strain (% of maximum HR (%HRmax)) increased in proportional manner relative to distance completed, and was regulated by variations in running pace; 2) the %HRmax achieved decreased with relative distance; 3) slower runners had similar %HRmax response within a racing distance compared to faster runners, and despite differences in pace, the profile of %HRmax during a race was very similar in runners of differing ability; and 4) in cases where there was a discontinuity in the running performance, there was evidence that physiologic effort was maintained for some time even after the pace had decreased.The overall results suggest that athletes are actively regulating their relative physiologic strain during competition, although there is evidence of poor regulation in the case of competitive failures.2.308 SJR (2008) Q1, 60/1774 Medicine (miscellaneous), 19/144 Biochemistry, genetics and molecular biology (miscellaneous), 15/175 Agricultural and biological sciences (miscellaneous)UE