The happiness - suicide paradox

Suicide is an important scientific phenomenon. Yet its causes remain poorly understood. This study documents a paradox: the happiest places have the highest suicide rates. The study combines findings from two large and rich individual-level data sets—one on life satisfaction and another on suicide deaths—to establish the paradox in a consistent way across U.S. states. It replicates the finding in data on Western industrialized nations and checks that the paradox is not an artifact of population composition or confounding factors. The study concludes with the conjecture that people may find it particularly painful to be unhappy in a happy place, so that the decision to commit suicide is influenced by relative comparisons.Happiness ; Suicide

Development of antibody-based assays for the detection of aflatoxins and organophosphates

The work described in this thesis involves the production and characterisation of antibodies and recombinant antibodies to aflatoxin Bi (AFBi), a potent mycotoxin and carcinogen. The antibodies produced were then applied for use in a surface plasmon resonance-based biosensor (BIAcore), which measures biomolecular interactions in ‘real-time’. Production of hapten-protein conjugates of the organophosphate pesticides chlorpyrifos and pirimiphos, and characterisation of antichlorpyrifos antibodies were also successfully performed. Rabbit polyclonal and single chain Fv (scFv) antibodies were produced to aflatoxin Bi. The scFv’s were produced from an established phage display system, which incorporated a range of different plasmids for scFv expression. Both sets of antibodies were used in the development of competitive ELISA’s and also for the development of BIAcore-based inhibition immunoassays. The antibodies were also used in the detection of AFBi in spiked grain samples by ELISA and BIAcore. Both the polyclonal and scFv antibodies were found to be suitable for the detection of AFBi, and the assays were reproducible. The production of an activated form of the organophosphate pirimiphos for the production of a pirimiphos-protein conjugate was attempted. However it was not possible to conjugate this pesticide by any suitable means. Chlorpyrifos-BSA conjugates were produced with different molar substitution ratios, and were used for the development of a competitive ELISA with polyclonal anti-chlorpyrifos antibodies

Urachal endometrioma: a case report

<p>Abstract</p> <p>Introduction</p> <p>We discuss a rare presentation of an unusual case of endometrioma.</p> <p>Case presentation</p> <p>A 40-year-old Caucasian woman presented with subacute abdominal pain and a suprapubic mass. A final diagnosis was made after the mass was resected and histopathology confirmed an endometrioma originating from an urachal remnant. Select imaging studies and histopathology are presented in this case report.</p> <p>Conclusion</p> <p>While endometriomata are well known to arise from abdominal scars, the condition described in this case report is a rare example of an endometrioma arising from the urachus. A review of the pathological complications of the urachus is also included.</p

Linking in situ Crystallisation and Magma Replenishment via Sill Intrusion in the Rum Western Layered Intrusion, NW Scotland

The construction of layered mafic-ultramafic intrusions has traditionally been attributed to gravity driven accumulation, involving the mechanical settling of crystals onto the magma chamber floor, at the interface between the crystal mush at the base and overlying replenishing magma, such that the layered sequence of cumulates (i.e., the crystal mush) at the floor aggrades upwards. The Rum Western Layered Intrusion (WLI) is a ~250 m sequence of layered peridotite cumulates comprising the structurally lowest portion of the Rum Layered Suite (RLS). As such, it is taken to represent the oldest sequence in the RLS and has been assumed to young upwards. The WLI hosts the largest proportion of harrisite, a cumulate composed of skeletal olivine that formed by in situ crystallisation, in the Rum layered intrusion. Harrisite layers in the WLI ubiquitously exhibit extremely irregular upward-oriented apophyses, up to several metres high and metres across, alongside laterally extensive dome-like structures; features consistent with intrusive, sill-like emplacement of harrisite. The distribution and abundance of harrisite therefore points to chaotic sill-like emplacement of the magmas that produced at least half of the WLI cumulate. This probably occurred various ambient crystal mush temperatures and punctuated intervals during cumulate formation. The harrisite layers are associated with numerous Cr-spinel seams occurring along the tops, bases, and interiors of these layers, suggesting they formed in situ alongside harrisite sills within the crystal mush. Detailed quantitative textural and mineral chemical analysis of Cr-spinel seams support a simple in situ crystallisation process for their formation. It is suggested the Cr-spinel seams form within melt channels that develop along the same hot tears that allowed the harrisite parental melts to enter the crystal mush. The chemistry and texture of Cr-spinel is controlled by the volume of through-flow of melt through the melt channel. Where melt flux through channels was high, sulphide and platinumgroup minerals are more abundant, highlighting the key economic implications of this model for the platinum-group element enrichment of chromitite horizons in layered intrusions. We also highlight the role of infiltration metasomatism at multiple levels of the WLI, where porous percolation of interstitial melt and reactive liquid flow played a key role in cumulate formation, supporting the notion of layered intrusion growth by incremental sill emplacement

Learned helplessness and the generality of social loafing

Theorists have suggested that social loafing is an instance of learned helplessness. We argue that this explanation is unwarranted in the absence of evidence that social loafing is generalized from one situation to another. We report an experiment consistent with our argument. College students working in a group performed more poorly at a word-generating task than subjects working by themselves, but this social loafing was not associated with subsequent problem-solving difficulties or with sad affect.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44331/1/10608_2005_Article_BF01177819.pd

Gas Phase Measurements of Mono-Fluoro-Benzoic Acids and the Dimer of 3-Fluoro-Benzoic Acid

The microwave spectrum of the mono-fluoro-benzoic acids, 2-fluoro-, 3-fluoro-, and 4-fluoro-benzoic acid have been measured in the frequency range of 4-14 GHz using a pulsed beam Fourier transform microwave spectrometer. Measured rotational transition lines were assigned and fit using a rigid rotor Hamiltonian. Assignments were made for 3 conformers of 2-fluorobenzoic acid, 2 conformers of 3-fluorobenzoic acid, and 1 conformer of 4-fluorobenzoic acid. Additionally, the gas phase homodimer of 3-fluorobenzoic acid was detected, and the spectra showed evidence of proton tunneling. Experimental rotational constants are A(0+) = 1151.8(5), B(0+) = 100.3(5), C(0+) = 87.64(3) MHz and A(0−) = 1152.2(5), B(0−) = 100.7(5), C(0−) = 88.85(3) MHz for the two ground vibrational states split by the proton tunneling motion. The tunneling splitting (ΔE) is approximately 560 MHz. This homodimer appears to be the largest carboxylic acid dimer observed with F-T microwave spectroscopy

Identification of mantle peridotite as a possible Iapetan ophiolite sliver in south Shetland, Scottish Caledonides

The Neoproterozoic Dunrossness Spilite Subgroup of south Shetland, Scotland, has been interpreted as a series of komatiitic and mafic lava flows formed in a marginal basin in response to Laurentian continental margin rifting. We show that ultramafic rocks previously identified as komatiites are depleted mantle peridotites that experienced seafloor hydrothermal alteration. The presence of positive Bouguer gravity and aeromagnetic anomalies extending from the Dunrossness Spilite Subgroup northward to the Shetland Ophiolite Complex suggests instead that these rocks may form part of an extensive ophiolite sliver, obducted during Iapetus Ocean closure in a forearc setting