356 research outputs found

    Automated evaluation of probe-based confocal laser endomicroscopy in the lung

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    Rationale Probe-based confocal endomicroscopy provides real time videos of autoflourescent elastin structures within the alveoli. With it, multiple changes in the elastin structure due to different diffuse parenchymal lung diseases have previously been described. However, these evaluations have mainly relied on qualitative evaluation by the examiner and manually selected parts post-examination. Objectives: To develop a fully automatic method for quantifying structural properties of the imaged alveoli elastin and to perform a preliminary assessment of their diagnostic potential. Methods 46 patients underwent probe-based confocal endomicroscopy, of which 38 were divided into 4 groups categorizing different diffuse parenchymal lung diseases. 8 patients were imaged in representative healthy lung areas and used as control group. Alveolar elastin structures were automatically segmented with a trained machine learning algorithm and subsequently evaluated with two methods developed for quantifying the local thickness and structural connectivity. Measurements and main results The automatic segmentation algorithm performed generally well and all 4 patient groups showed statistically significant differences with median elastin thickness, standard deviation of thickness and connectivity compared to the control group. Conclusion Alveoli elastin structures can be quantified based on their structural connectivity and thickness statistics with a fully-automated algorithm and initial results highlight its potential for distinguishing parenchymal lung diseases from normal alveoli

    A comparison of the cylinder power and axis resulting from the modification of the gross opthalmometer cylinder by combining it with the hypothetical internal astigmatism with the clinically acceptable cylinder habitually worn by the subject

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    A comparison of the cylinder power and axis resulting from the modification of the gross opthalmometer cylinder by combining it with the hypothetical internal astigmatism with the clinically acceptable cylinder habitually worn by the subjec

    Zeeman Perturbed 63^{63}Cu Nuclear Quadrupole Resonance Study of the Vortex State of YBa2_2Cu3_3O7δ_{7-\delta}

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    We report a 63^{63}Cu nuclear quadrupole resonance (NQR) study of the vortex state for an aligned polycrystalline sample of a slightly overdoped high-TcT_c superconductor YBa2_2Cu3_3O7δ_{7-\delta} (TcT_{c}\sim92 K) at a low magnetic field of 96 mT along the c axis, near a lower critical field Hc1H_{c1}. We observed the frequency distribution of the nuclear spin-lattice relaxation time 63T1^{63}T_1 in the Zeeman-perturbed 63^{63}Cu NQR spectrum below TcT_c. The characteristic behavior of 1/63T1^{63}T_1, taking the minimum values with respect to temperature and frequency, indicates the significant role of antiferromagnetic spin fluctuations in the Doppler-shifted quasiparticle energy spectrum inside and outside vortex cores.Comment: 4 pages, 4 figure

    Theory of vortex excitation imaging via an NMR relaxation measurement

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    The temperature dependence of the site-dependent nuclear spin relaxation time T_1 around vortices is studied in s-wave and d-wave superconductors.Reflecting low energy electronic excitations associated with the vortex core, temperature dependences deviate from those of the zero-field case, and T_1 becomes faster with approaching the vortex core. In the core region, T_1^{-1} has a new peak below T_c. The NMR study by the resonance field dependence may be a new method to prove the spatial resolved vortex core structure in various superconductors.Comment: 5 pages, 3 figure

    Photoconductive Detectors with Fast Temporal Response for Laser Produced Plasma Experiments.

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    Processes during laser plasma experiments typically have time scales that are less than 100 ps. The measurement of these processes requires X-ray detectors with fast temporal resolution. We have measured the temporal responses and linearity of several different X-ray sensitive Photoconductive Detectors (PCDs). The active elements of the detectors investigated include both diamond (natural and synthetic) and GaAs crystals. The typical time responses of the GaAs PCDs are approximately 60 ps, respectively. Some characterizations using X-ray light from a synchrotron light source are presented

    Site-selective nuclear magnetic relaxation time in a superconducting vortex state

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    The temperature and field dependences of the site-selective nuclear spin relaxation time T_1 around vortices are studied comparatively both for s-wave and d-wave superconductors, based on the microscopic Bogoliubov-de Gennes theory. Reflecting low energy electronic excitations associated with the vortex core, the site selective temperature dependences deviate from those of the zero-field case, and T_1 becomes faster with approaching the vortex core. In the core region, T_1^{-1} has a new peak below the superconducting transition temperature T_c. The field dependence of the overall T_1(T) behaviors for s-wave and d-wave superconductors is investigated and analyzed in terms of the local density of states. The NMR study by the resonance field dependence may be a new method to probe the spatial resolved vortex core structure in various conventional and unconventional superconductors.Comment: 14Pages, 26 figures, revte
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