11 research outputs found
Analysis of lectin-dependent recognition of desialylated erythrocytes by Kupffer cells
Full text linkLectin Mediates Homing of Sialidase-Treated Erythrocytes of the Liver as Revealed by Scintigraphy
No full textFlow cytofluorimetric analysis of young and senescent human erythrocytes probed with lectins. Evidence that sialic acids control their life span
No full text
Opsonizing properties of an isolated hemolymph agglutinin and demonstration of lectin-like recognition molecules at the surface of hemocytes fromMytilus edulis
No full textNitric Oxide Generation during Cellular Metabolization of the Diabetogenic N-Mefhyl-N-Nitroso-Urea Streptozotozin Contributes to Islet Cell DNA Damage
No full textUDP-Gal: N-acetylglucosamine β 1–4 galactosyltransferase expressing live attenuated parasites as vaccine for visceral leishmaniasis
No full textAs compared to cutaneous leishmaniasis, vaccination
against visceral leishmaniasis (VL) has received
limited attention. In this study, we demonstrate for the first
time that an UDP-Galactose: N-acetylglucosamine β 1–4
galactosyltransferase (GenBank Accession No. EF159943)
expressing attenuated LD clonal population (A-LD) is able
to confer protection against the experimental challenge with
the virulent LD AG83 parasite. A-LD was also effective in
established leishmania infection. The vaccinated animals
showed both cell mediated (in vitro T-cell proliferation, and
DTH response) and humoral responses (Th1 type). These
results demonstrate the potential of the attenuated clones as
an immunotherapeutic and immunoprophylactic agent
against visceral leishmaniasis
