229 research outputs found
Whirling spin order in the quasicrystal approximant AuAlTb
Neutron powder diffraction experiment has been performed on the quasicrystal
approximant AuAlTb, a body-center-cubic crystal of
icosahedral spin clusters. The long-range antiferromagnetic order was confirmed
at the transition temperature K. The magnetic structure
consists of noncoplanar whirling spins on the icosahedral clusters, arranging
antiferroic-manner. A simple icosahedral spin-cluster model with uniaxial
anisotropy accounts well the whirling spin order as well as the in-field
metamagnetic transition, indicating that the icosahedral symmetry is essential.Comment: 6 pages, 4 figure
Photoluminescence from silicon dioxide photonic crystal cavities with embedded silicon nanocrystals
One dimensional nanobeam photonic crystal cavities are fabricated in silicon
dioxide with silicon nanocrystals. Quality factors of over 9 x 10^3 are found
in experiment, matching theoretical predictions, with mode volumes of
1.5(lambda/n)^3 . Photoluminescence from the cavity modes is observed in the
visible wavelength range 600-820 nm. Studies of the lossy characteristics of
the cavities are conducted at varying temperatures and pump powers. Free
carrier absorption effects are found to be significant at pump powers as low as
a few hundred nanowatts.Comment: 13 pages 9 figure
Persistence of Covalent Bonding in Liquid Silicon Probed by Inelastic X-ray Scattering
Metallic liquid silicon at 1787K is investigated using x-ray Compton
scattering. An excellent agreement is found between the measurements and the
corresponding Car-Parrinello molecular dynamics simulations. Our results show
persistence of covalent bonding in liquid silicon and provide support for the
occurrence of theoretically predicted liquid-liquid phase transition in
supercooled liquid states. The population of covalent bond pairs in liquid
silicon is estimated to be 17% via a maximally-localized Wannier function
analysis. Compton scattering is shown to be a sensitive probe of bonding
effects in the liquid state.Comment: 5pages, 3 postscript figure
Mesonic decay constants in lattice NRQCD
Lattice NRQCD with leading finite lattice spacing errors removed is used to
calculate decay constants of mesons made up of heavy quarks. Quenched
simulations are done with a tadpole improved gauge action containing plaquette
and six-link rectangular terms. The tadpole factor is estimated using the
Landau link. For each of the three values of the coupling constant considered,
quarkonia are calculated for five masses spanning the range from charmonium
through bottomonium, and one set of quark masses is tuned to the B(c).
"Perturbative" and nonperturbative meson masses are compared. One-loop
perturbative matching of lattice NRQCD with continuum QCD for the heavy-heavy
vector and axial vector currents is performed. The data are consistent with the
vector meson decay constants of quarkonia being proportional to the square root
of their mass and the B(c) decay constant being equal to 420(13) MeV.Comment: 25 pages in REVTe
Dimerization of Tetherin Is Not Essential for Its Antiviral Activity against Lassa and Marburg Viruses
Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined. Both ends of the tetherin molecule are associated with the plasma membrane and it forms a homodimer. Therefore, a model in which progeny virions are retained on the cell surface by dimer formation between tetherin molecules on the viral envelope and plasma membrane has been proposed as the antiviral mechanism of action of this molecule. To investigate this possibility, we examined the correlation between dimerization and antiviral activity of tetherin in Lassa and Marburg virus-like particle production systems using tetherin mutants deficient in dimer formation. However, the tetherin mutant with complete loss of dimerization activity still showed apparent antiviral activity, indicating that dimerization of tetherin is not essential for its antiviral activity. This suggests that tetherin retains progeny virions on the cell surface by a mechanism other than dimerization
Bulk Electronic structure of NaCoO.1.3HO
High-energy (h = 5.95 keV) synchrotron Photoemission spectroscopy (PES)
is used to study bulk electronic structure of NaCoO.1.3HO,
the layered superconductor. In contrast to 3-dimensional doped Co oxides, Co
core level spectra show well-separated Co and Co ions.
Cluster calculations suggest low spin Co and Co character, and a
moderate on-site Coulomb correlation energy U3-5.5 eV. Photon
dependent valence band PES identifies Co and O derived
states, in near agreement with band structure calculations.Comment: 4 pages 4 figures Revised text added referenc
Sex-Linked Pheromone Receptor Genes of the European Corn Borer, Ostrinia nubilalis, Are in Tandem Arrays
BACKGROUND: Tuning of the olfactory system of male moths to conspecific female sex pheromones is crucial for correct species recognition; however, little is known about the genetic changes that drive speciation in this system. Moths of the genus Ostrinia are good models to elucidate this question, since significant differences in pheromone blends are observed within and among species. Odorant receptors (ORs) play a critical role in recognition of female sex pheromones; eight types of OR genes expressed in male antennae were previously reported in Ostrinia moths. METHODOLOGY/PRINCIPAL FINDINGS: We screened an O. nubilalis bacterial artificial chromosome (BAC) library by PCR, and constructed three contigs from isolated clones containing the reported OR genes. Fluorescence in situ hybridization (FISH) analysis using these clones as probes demonstrated that the largest contig, which contained eight OR genes, was located on the Z chromosome; two others harboring two and one OR genes were found on two autosomes. Sequence determination of BAC clones revealed the Z-linked OR genes were closely related and tandemly arrayed; moreover, four of them shared 181-bp direct repeats spanning exon 7 and intron 7. CONCLUSIONS/SIGNIFICANCE: This is the first report of tandemly arrayed sex pheromone receptor genes in Lepidoptera. The localization of an OR gene cluster on the Z chromosome agrees with previous findings for a Z-linked locus responsible for O. nubilalis male behavioral response to sex pheromone. The 181-bp direct repeats might enhance gene duplications by unequal crossovers. An autosomal locus responsible for male response to sex pheromone in Heliothis virescens and H. subflexa was recently reported to contain at least four OR genes. Taken together, these findings support the hypothesis that generation of additional copies of OR genes can increase the potential for male moths to acquire altered specificity for pheromone components, and accordingly, facilitate differentiation of sex pheromones
The carboxy-terminal fragment of α1A calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells
Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant neurodegenerative disease caused by a small polyglutamine (polyQ) expansion (control: 4–20Q; SCA6: 20–33Q) in the carboxyl(C)-terminal cytoplasmic domain of the α1A voltage-dependent calcium channel (Cav2.1). Although a 75–85-kDa Cav2.1 C-terminal fragment (CTF) is toxic in cultured cells, its existence in human brains and its role in SCA6 pathogenesis remains unknown. Here, we investigated whether the small polyQ expansion alters the expression pattern and intracellular distribution of Cav2.1 in human SCA6 brains. New antibodies against the Cav2.1 C-terminus were used in immunoblotting and immunohistochemistry. In the cerebella of six control individuals, the CTF was detected in sucrose- and SDS-soluble cytosolic fractions; in the cerebella of two SCA6 patients, it was additionally detected in SDS-insoluble cytosolic and sucrose-soluble nuclear fractions. In contrast, however, the CTF was not detected either in the nuclear fraction or in the SDS-insoluble cytosolic fraction of SCA6 extracerebellar tissues, indicating that the CTF being insoluble in the cytoplasm or mislocalized to the nucleus only in the SCA6 cerebellum. Immunohistochemistry revealed abundant aggregates in cell bodies and dendrites of SCA6 Purkinje cells (seven patients) but not in controls (n = 6). Recombinant CTF with a small polyQ expansion (rCTF-Q28) aggregated in cultured PC12 cells, but neither rCTF-Q13 (normal-length polyQ) nor full-length Cav2.1 with Q28 did. We conclude that SCA6 pathogenesis may be associated with the CTF, normally found in the cytoplasm, being aggregated in the cytoplasm and additionally distributed in the nucleus
Skeletal Muscle-Specific Ablation of γcyto-Actin Does Not Exacerbate the mdx Phenotype
We previously documented a ten-fold increase in γcyto-actin expression in dystrophin-deficient skeletal muscle and hypothesized that increased γcyto-actin expression may participate in an adaptive cytoskeletal remodeling response. To explore whether increased γcyto-actin fortifies the cortical cytoskeleton in dystrophic skeletal muscle, we generated double knockout mice lacking both dystrophin and γcyto-actin specifically in skeletal muscle (ms-DKO). Surprisingly, dystrophin-deficient mdx and ms-DKO mice presented with comparable levels of myofiber necrosis, membrane instability, and deficits in muscle function. The lack of an exacerbated phenotype in ms-DKO mice suggests γcyto-actin and dystrophin function in a common pathway. Finally, because both mdx and ms-DKO skeletal muscle showed similar levels of utrophin expression and presented with identical dystrophies, we conclude utrophin can partially compensate for the loss of dystrophin independent of a γcyto-actin-utrophin interaction
- …