Paediatric Recurrent Ear, Nose and Throat Infections and Complications: Can We Do More?

Recurrent respiratory tract infections (rRTIs), of which there are three main groups—otitis media, tonsillitis and sinusopathies—are very common in paediatric populations and are associated with significant morbidity and mortality due to complications. These infections substantially reduce quality of life for paediatric patients and their families and are a significant personal, medical and economic burden on the patients, the patients’ families and the healthcare system. Most rRTIs are of viral origin; however, indiscriminate use of antibiotics in their treatment has led to development of bacterial resistance. Effective management of rRTIs to reduce the burden of disease and to avoid overuse of antibiotics has become a great therapeutic challenge. New strategies for the management of paediatric rRTIs include focus on prevention using non-specific immunomodulators to boost the body’s natural defences against infection and to downregulate infection- and allergen-induced airway inflammation. The oral immunomodulator, OM-85, a bacterial lysate, acts on the innate and adaptive branches of the immune system, conferring protection against viral and bacterial infections, and controls inflammation, thereby reducing tissue damage. OM-85 has demonstrated good tolerability and clinical efficacy in reducing the number and duration of RTIs in children with recurrent airway infections. It has also been reported to reduce the use of concomitant medications, including antibiotics, time to cure and school absenteeism. OM-85 is efficacious and well tolerated when administered concomitantly with inactivated influenza vaccine (IIV) and has been shown to reduce wheezing attacks induced by RTI in young children. Clinical results show that the greater the risk of rRTIs, the greater the benefit with OM-85. OM-85 may be considered a promising tool to add to the limited armamentarium of the ear, nose and throat (ENT) physician dealing with rRTIs and their complications, such as recurrent wheeze and asthma inception

Optical and Near-Infrared UBVRIJHK Photometry for the RR Lyrae stars in the Nearby Globular Cluster M4 (NGC 6121)

We present optical and near-infrared UBVRIJHK photometry of stars in the Galactic globular cluster M4 (NGC 6121) based upon a large corpus of observations obtained mainly from public astronomical archives. We concentrate on the RR Lyrae variable stars in the cluster, and make a particular effort to accurately reidentify the previously discovered variables. We have also discovered two new probable RR Lyrae variables in the M4 field: one of them by its position on the sky and its photometric properties is a probable member of the cluster, and the second is a probable background (bulge?) object. We provide accurate equatorial coordinates for all 47 stars identified as RR Lyraes, new photometric measurements for 46 of them, and new period estimates for 45. We have also derived accurate positions and mean photometry for 34 more stars previously identified as variable stars of other types, and for an additional five non-RR Lyrae variable stars identified for the first time here. We present optical and near-infrared color-magnitude diagrams for the cluster and show the locations of the variable stars in them. We present the Bailey (period-amplitude) diagrams and the period-frequency histogram for the RR Lyrae stars in M4 and compare them to the corresponding diagrams for M5 (NGC 5904). We conclude that the RR Lyrae populations in the two clusters are quite similar in all the relevant properties that we have considered. The mean periods, pulsation-mode ratios, and Bailey diagrams of these two clusters show support for the recently proposed "Oosterhoff-neutral" classification.Comment: 33 pages, 16 figures, 7 table

Building on strategic elearning initiatives of hybrid graduate education a case study approach: MHEI-ME Erasmus+ Project

Online courses are gaining popularity because they provide extensive and varied course material, information, knowledge, and skills, whilst also creating an effective educational online community. This research adopts a case study approach to focus on the teaching method and the manner in which a strategic commitment to eLearning provides scope for the development and implementation of top quality educational online fully accredited programs. Entrepreneurship focuses on developing businesses that add value and create wealth and prosperity in our societies. Therefore, entrepreneurship is a key area of learning for graduate students seeking to set up and operate their own SME organizations. It can serve as a benchmark for the teaching of other graduate subjects that require a sound correlation for the correlation of concepts and theories to the challenging complexities of the real world. The program was developed on the basis of the implementation of a state-of-the-art eLearning platform that allowed for a combination of varied self-learning and collaborative learning elements and activities within a single platform. This enabled students to access the online content material efficiently and effectively. It allows for the development of a program based on the flipped classroom teaching methodology. The underlying concept of the flipped classroom methodology is that effective eLearning should comprise both synchronous and asynchronous learning activities. This combination of self-learning and collaborative learning calls for careful planning by the tutor to ensure that the learning objectives are clearly defined for each activity and that the relevant deliverables are monitored. The content material for each subject course module was designed, developed, produced, and presented by the different project partners in a holistic manner structured to motivate participants to learn. The results of our analysis have shown that students were able to learn, discuss their projects, and cooperate during an online course in an effective and participant-focused manner with their tutors. The feedback given highlights the importance of ongoing communications between students and the tutors who often need to act as mentors to retain student engagement. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Cepheid limb darkening, angular diameter corrections, and projection factor from static spherical model stellar atmospheres

Context. One challenge for measuring the Hubble constant using Classical Cepheids is the calibration of the Leavitt Law or period-luminosity relationship. The Baade-Wesselink method for distance determination to Cepheids relies on the ratio of the measured radial velocity and pulsation velocity, the so-called projection factor and the ability to measure the stellar angular diameters. Aims. We use spherically-symmetric model stellar atmospheres to explore the dependence of the p-factor and angular diameter corrections as a function of pulsation period. Methods. Intensity profiles are computed from a grid of plane-parallel and spherically-symmetric model stellar atmospheres using the SAtlas code. Projection factors and angular diameter corrections are determined from these intensity profiles and compared to previous results. Results. Our predicted geometric period-projection factor relation including previously published state-of-the-art hydrodynamical predictions is not with recent observational constraints. We suggest a number of potential resolutions to this discrepancy. The model atmosphere geometry also affects predictions for angular diameter corrections used to interpret interferometric observations, suggesting corrections used in the past underestimated Cepheid angular diameters by 3 - 5%. Conclusions. While spherically-symmetric hydrostatic model atmospheres cannot resolve differences between projection factors from theory and observations, they do help constrain underlying physics that must be included, including chromospheres and mass loss. The models also predict more physically-based limb-darkening corrections for interferometric observations.Comment: 8 pages, 6 figures, 2 tables, accepted for publication in A&

A Spitzer IRAC Imaging Survey for T Dwarf Companions Around M, L, and T Dwarfs: Observations, Results, and Monte Carlo Population Analyses

We report observational techniques, results, and Monte Carlo population analyses from a Spitzer Infrared Array Camera imaging survey for substellar companions to 117 nearby M, L, and T dwarf systems (median distance of 10 pc, mass range of 0.6 to \sim0.05 M\odot). The two-epoch survey achieves typical detection sensitivities to substellar companions of [4.5 {\mu}m] \leq 17.2 mag for angular separations between about 7" and 165". Based on common proper motion analysis, we find no evidence for new substellar companions. Using Monte Carlo orbital simulations (assuming random inclination, random eccentricity, and random longitude of pericenter), we conclude that the observational sensitivities translate to an ability to detect 600-1100K brown dwarf companions at semimajor axes greater than ~35 AU, and to detect 500-600K companions at semimajor axes greater than ~60 AU. The simulations also estimate a 600-1100K T dwarf companion fraction of < 3.4% for 35-1200 AU separations, and < 12.4% for the 500-600K companions, for 60-1000 AU separations.Comment: 35 pages, 6 figure

HD 145263: Spectral Observations of Silica Debris Disk Formation via Extreme Space Weathering?

We report here time domain infrared spectroscopy and optical photometry of the HD145263 silica-rich circumstellar disk system taken from 2003 through 2014. We find an F4V host star surrounded by a stable, massive 1e22 - 1e23 kg (M_Moon to M_Mars) dust disk. No disk gas was detected, and the primary star was seen rotating with a rapid ~1.75 day period. After resolving a problem with previously reported observations, we find the silica, Mg-olivine, and Fe-pyroxene mineralogy of the dust disk to be stable throughout, and very unusual compared to the ferromagnesian silicates typically found in primordial and debris disks. By comparison with mid-infrared spectral features of primitive solar system dust, we explore the possibility that HD 145263's circumstellar dust mineralogy occurred with preferential destruction of Fe-bearing olivines, metal sulfides, and water ice in an initially comet-like mineral mix and their replacement by Fe-bearing pyroxenes, amorphous pyroxene, and silica. We reject models based on vaporizing optical stellar megaflares, aqueous alteration, or giant hypervelocity impacts as unable to produce the observed mineralogy. Scenarios involving unusually high Si abundances are at odds with the normal stellar absorption near-infrared feature strengths for Mg, Fe, and Si. Models involving intense space weathering of a thin surface patina via moderate (T < 1300 K) heating and energetic ion sputtering due to a stellar superflare from the F4V primary are consistent with the observations. The space weathered patina should be reddened, contain copious amounts of nanophase Fe, and should be transient on timescales of decades unless replenished.Comment: 41 Pages, 5 Figures, 5 Tables, Accepted for publication in the Astrophysical Journa

Discovery of Two T Dwarf Companions with the Spitzer Space Telescope

We report the discovery of T dwarf companions to the nearby stars HN Peg (G0V, 18.4 pc, ~0.3 Gyr) and HD 3651 (K0V, 11.1 pc, ~7 Gyr). During an ongoing survey of 5'x5' fields surrounding stars in the solar neighborhood with IRAC aboard the Spitzer Space Telescope, we identified these companions as candidate T dwarfs based on their mid-IR colors. Using near-IR spectra obtained with SpeX at the NASA IRTF, we confirm the presence of methane absorption that characterizes T dwarfs and measure spectral types of T2.5+/-0.5 and T7.5+/-0.5 for HN Peg B and HD 3651 B, respectively. By comparing our Spitzer data to images from 2MASS obtained several years earlier, we find that the proper motions of HN Peg B and HD 3651 B are consistent with those of the primaries, confirming their companionship. HN Peg B and HD 3651 B have angular separations of 43.2" and 42.9" from their primaries, which correspond to projected physical separations of 795 and 476 AU, respectively. A comparison of their luminosities to the values predicted by theoretical evolutionary models implies masses of 0.021+/-0.009 and 0.051+/-0.014 Msun for HN Peg B and HD 3651 B. In addition, the models imply an effective temperature for HN Peg B that is significantly lower than the values derived for other T dwarfs at similar spectral types, which is the same behavior reported by Metchev & Hillenbrand for the young late-L dwarf HD 203030 B. Thus, the temperature of the L/T transition appears to depend on surface gravity. Meanwhile, HD 3651 B is the first substellar companion directly imaged around a star that is known to harbor a close-in planet from RV surveys. The discovery of this companion supports the notion that the high eccentricities of close-in planets like the one near HD 3651 may be the result of perturbations by low-mass companions at wide separations.Comment: Astrophysical Journal, in pres

The Spitzer discovery of a galaxy with infrared emission solely due to AGN activity

We present a galaxy (SAGE1CJ053634.78-722658.5) at a redshift of 0.14 of which the IR is entirely dominated by emission associated with the AGN. We present the 5-37 um Spitzer/IRS spectrum and broad wavelength SED of SAGE1CJ053634, an IR point-source detected by Spitzer/SAGE (Meixner et al 2006). The source was observed in the SAGE-Spec program (Kemper et al., 2010) and was included to determine the nature of sources with deviant IR colours. The spectrum shows a redshifted (z=0.14+-0.005) silicate emission feature with an exceptionally high feature-to-continuum ratio and weak polycyclic aromatic hydrocarbon (PAH) bands. We compare the source with models of emission from dusty tori around AGNs from Nenkova et al. (2008). We present a diagnostic diagram that will help to identify similar sources based on Spitzer/MIPS and Herschel/PACS photometry. The SED of SAGE1CJ053634 is peculiar because it lacks far-IR emission and a clear stellar counterpart. We find that the SED and the IR spectrum can be understood as emission originating from the inner ~10 pc around an accreting black hole. There is no need to invoke emission from the host galaxy, either from the stars or from the interstellar medium, although a possible early-type host galaxy cannot be excluded based on the SED analysis. The hot dust around the accretion disk gives rise to a continuum, which peaks at 4 um, whereas the strong silicate features may arise from optically thin emission of dusty clouds within ~10 pc around the black hole. The weak PAH emission does not appear to be linked to star formation, as star formation templates strongly over-predict the measured far-IR flux levels. The SED of SAGE1CJ053634 is rare in the local universe but may be more common in the more distant universe. The conspicuous absence of host-galaxy IR emission places limits on the far-IR emission arising from the dusty torus alone.Comment: Accepted for publication in A&A, 7 pages, 6 figure

Photometric identification of blue horizontal branch stars

We investigate the performance of some common machine learning techniques in identifying BHB stars from photometric data. To train the machine learning algorithms, we use previously published spectroscopic identifications of BHB stars from SDSS data. We investigate the performance of three different techniques, namely k nearest neighbour classification, kernel density estimation and a support vector machine (SVM). We discuss the performance of the methods in terms of both completeness and contamination. We discuss the prospect of trading off these values, achieving lower contamination at the expense of lower completeness, by adjusting probability thresholds for the classification. We also discuss the role of prior probabilities in the classification performance, and we assess via simulations the reliability of the dataset used for training. Overall it seems that no-prior gives the best completeness, but adopting a prior lowers the contamination. We find that the SVM generally delivers the lowest contamination for a given level of completeness, and so is our method of choice. Finally, we classify a large sample of SDSS DR7 photometry using the SVM trained on the spectroscopic sample. We identify 27,074 probable BHB stars out of a sample of 294,652 stars. We derive photometric parallaxes and demonstrate that our results are reasonable by comparing to known distances for a selection of globular clusters. We attach our classifications, including probabilities, as an electronic table, so that they can be used either directly as a BHB star catalogue, or as priors to a spectroscopic or other classification method. We also provide our final models so that they can be directly applied to new data.Comment: To appear in A&A. 19 pages, 22 figures. Tables 7, A3 and A4 available electronically onlin

Mid-IR period-magnitude relations for AGB stars

Asymptotic Giant Branch variables are found to obey period-luminosity relations in the mid-IR similar to those seen at K_S (2.14 microns), even at 24 microns where emission from circumstellar dust is expected to be dominant. Their loci in the M, logP diagrams are essentially the same for the LMC and for NGC6522 in spite of different ages and metallicities. There is no systematic trend of slope with wavelength. The offsets of the apparent magnitude vs. logP relations imply a difference between the two fields of 3.8 in distance modulus. The colours of the variables confirm that a principal period with log P > 1.75 is a necessary condition for detectable mass-loss. At the longest observed wavelength, 24 microns, many semi-regular variables have dust shells comparable in luminosity to those around Miras. There is a clear bifurcation in LMC colour-magnitude diagrams involving 24 micron magnitudes.Comment: 5 pages, 4 figure